Personal Profile
Home → Directory → Faculty → Margit Maria JanŠt Amsbury
Margit Maria  JanŠt Amsbury
E-mail:

Phone: 801-213-2248

Margit Maria JanŠt Amsbury

Assistant Professor, Obstetrics and Gynecology-Research Director Division of Gynecologic Oncology
Assistant Professor, Pharmaceutics and Pharmaceutical Chemistry
Adjunct Assistant Professor, Bioengineering
Medical School: Universitaet zu Koeln (Cologne), Germany
Residency: Internship Mount Sinai School of Medicine, New York; OB/Gyn Universitaet zu Koeln (Cologne), Germany
Fellowship: Gene-and Drug Delivery , University of Utah Salt Lake City, OB/Gyn Acad

Research

Animal Cancer Models, Gynecologic Malignancies: Ovarian, Endometrial, Cervical Cancer, Gene-and Drug Delivery, Women's Health


Current Research

Animal Cancer Models:
1. Cancer Models in immune-competent hosts (Ovarian Cancer)
2. Patient-derived Xenograft Cancer Models (Endometrial Cancer)
3. Animal Cancer Models utilizing Cell Sheet Tissue Engineering Technologies
4. Induced cancer stem cell (iCSC) animal cancer models.

Gene-Drug Delivery:
Development of intraperitoneal and vaginal delivery systems.


Selected Publications

Taurin S, Yang CH, Reyes M, Cho S, Coombs DM, Jarboe EA, Werner TL, Peterson CM, JanŠt-Amsbury MM, Endometrial Cancers Harboring Mutated Fibroblast Growth Factor Receptor 2 Protein Are Successfully Treated With a New Small Tyrosine Kinase Inhibitor in an Orthotopic Mouse Model. Int J Gynecol Cancer 2017 Sep 26;:

Arellano JA, Howell TA, Gammon J, Cho S, JanŠt-Amsbury MM, Gale B, Use of a highly parallel microfluidic flow cell array to determine therapeutic drug dose response curves. Biomed Microdevices 2017 Jun;19(2):25

Almomen A, Jarboe EA, Dodson MK, Peterson CM, Owen SC, JanŠt-Amsbury MM, Imiquimod Induces Apoptosis in Human Endometrial Cancer Cells†In vitro and Prevents Tumor Progression In vivo. Pharm Res 2016 Sep;33(9):2209-17

Park H, Cho S, Janat-Amsbury MM, Bae YH, Enhanced thermogenic program by non-viral delivery of combinatory browning genes to treat diet-induced obesity in mice. Biomaterials 2015 Dec;73:32-41

Almomen AA, Cho S, Li Z, Huh KM, Matthew Peterson C, JanŠt-Amsbury MM, A thermosensitive glycol chitin hydrogel for the vaginal delivery of progesterone. J Control Release 2015 Sep 10;213:e74-5

Stirland DL, Nichols JW, Jarboe E, Adelman M, Dassel M, JanŠt-Amsbury MM, Bae YH, Uterine perfusion model for analyzing barriers to transport in fibroids. J Control Release 2015 Sep 28;214:85-93

Yang CH, Almomen A, Wee YS, Jarboe EA, Peterson CM, JanŠt-Amsbury MM, An estrogen-induced endometrial hyperplasia mouse model recapitulating human disease progression and genetic aberrations. Cancer Med 2015 Jul;4(7):1039-50

Almomen A, Cho S, Yang CH, Li Z, Jarboe EA, Peterson CM, Huh KM, JanŠt-Amsbury MM, Thermosensitive progesterone hydrogel: a safe and effective new formulation for vaginal application. Pharm Res 2015 Jul;32(7):2266-79

Park H, Cho S, Han YH, Janat-Amsbury MM, Boudina S, Bae YH, Combinatorial gene construct and non-viral delivery for anti-obesity in diet-induced obese mice. J Control Release 2015 Jun 10;207:154-62

Cho S, Park H, Jarboe EA, Peterson CM, Bae YH, JanŠt-Amsbury MM, Design and Characterization of Bioengineered Cancer-Like Stem Cells. PLoS One 2015;10(10):e0141172

Okal A, Matissek KJ, Matissek SJ, Price R, Salama ME, JanŠt-Amsbury MM, Lim CS, Re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant negative breast cancer xenograft model. Gene Ther 2014 Oct;21(10):903-12

Florinas S, Kim J, Nam K, JanŠt-Amsbury MM, Kim SW, Ultrasound-assisted siRNA delivery via arginine-grafted bioreducible polymer and microbubbles targeting VEGF for ovarian cancer treatment. J Control Release 2014 Jun 10;183:1-8

Cho S, Sun Y, Jarboe EA, Soisson AP, Dodson MK, Gaffney DK, Peterson CM, JanŠt-Amsbury MM, Mucoadhesive hybrid gel improves intraperitoneal platinum delivery. Int J Pharm 2013 Dec 15;458(1):148-55

Sadekar S, Linares O, Noh G, Hubbard D, Ray A, JanŠt-Amsbury M, Peterson CM, Facelli J, Ghandehari H, COMPARATIVE PHARMACOKINETICS OF PAMAM-OH DENDRIMERS AND HPMA COPOLYMERS IN OVARIAN-TUMOR-BEARING MICE. Drug Deliv Transl Res 2013 Jun 1;3(3):260-271

Cho S, Sun Y, Soisson AP, Dodson MK, Peterson CM, Jarboe EA, Kennedy AM, JanŠt-Amsbury MM, Characterization and evaluation of pre-clinical suitability of a syngeneic orthotopic mouse ovarian cancer model. Anticancer Res 2013 Apr;33(4):1317-24

Li Z, Cho S, Kwon IC, JanŠt-Amsbury MM, Huh KM, Preparation and characterization of glycol chitin as a new thermogelling polymer for biomedical applications. Carbohydr Polym 2013 Feb 15;92(2):2267-75

Zhang R, Luo K, Yang J, Sima M, Sun Y, JanŠt-Amsbury MM, Kopecek J, Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel. J Control Release 2013 Feb 28;166(1):66-74

Arnida, JanŠt-Amsbury MM, Ray A, Peterson CM, Ghandehari H, Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages. Eur J Pharm Biopharm 2011 Apr;77(3):417-23

Sadekar S, Ray A, Janŗt-Amsbury M, Peterson CM, Ghandehari H, Comparative biodistribution of PAMAM dendrimers and HPMA copolymers in ovarian-tumor-bearing mice. Biomacromolecules 2011 Jan 10;12(1):88-96

JanŠt-Amsbury MM, Gupta KM, Kablitz CD, Peterson CM, Drug delivery for in vitro fertilization: rationale, current strategies and challenges. Adv Drug Deliv Rev 2009 Aug 10;61(10):871-82

JanŠt-Amsbury MM, Peterson CM, Kim SW, The role of gene- and drug delivery in women's health--unmet clinical needs and future opportunities. Preface. Adv Drug Deliv Rev 2009 Aug 10;61(10):767

JanŠt-Amsbury MM, Yockman JW, Anderson ML, Kieback DG, Kim SW, Combination of local, non-viral IL12 gene therapy and systemic paclitaxel chemotherapy in a syngeneic ID8 mouse model for human ovarian cancer. Anticancer Res 2006 Sep-Oct;26(5A):3223-8

JanŠt-Amsbury MM, Yockman JW, Anderson ML, Kieback DG, Kim SW, Comparison of ID8 MOSE and VEGF-modified ID8 cell lines in an immunocompetent animal model for human ovarian cancer. Anticancer Res 2006 Jul-Aug;26(4B):2785-9

Bikram M, Lee M, Chang CW, JanŠt-Amsbury MM, Kern SE, Kim SW, Long-circulating DNA-complexed biodegradable multiblock copolymers for gene delivery: degradation profiles and evidence of dysopsonization. J Control Release 2005 Mar 2;103(1):221-33

JanŠt-Amsbury MM, Yockman JW, Lee M, Kern S, Furgeson DY, Bikram M, Kim SW, Local, non-viral IL-12 gene therapy using a water soluble lipopolymer as carrier system combined with systemic paclitaxel for cancer treatment. J Control Release 2005 Jan 3;101(1-3):273-85

JanŠt-Amsbury MM, Yockman JW, Lee M, Kern S, Furgeson DY, Bikram M, Kim SW, Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model. Mol Ther 2004 Jun;9(6):829-36