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Brian  Mickey
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Phone: 801-581-7952
Office: 383 Colorow Dr

Brian Mickey

Associate Professor of Psychiatry
Adjunct Associate Professor, Bioengineering
BS/BS, Physics/Biology, University of Washington, Seattle
MD/PhD, Medicine/Neuroscience, University of Michigan, Ann Arbor
Residency/Fellowship, Psychiatry, Molecular & Behavioral Neuroscience Institute, University of Michigan

Research

Neuroscience of mood disorders


Current Research

Neuroimaging of mood disorders
Neural mechanisms of motivation and pleasure
Treatment-resistant depression and bipolar disorder
Brain stimulation therapies


Selected Publications

Peciņa M, Sikora M, Avery ET, Heffernan J, Peciņa S, Mickey BJ, Zubieta JK, Striatal dopamine D2/3 receptor-mediated neurotransmission in major depression: Implications for anhedonia, anxiety and treatment response. Eur Neuropsychopharmacol 2017 Oct;27(10):977-986

Mickey BJ, Heffernan J, Heisel C, Peciņa M, Hsu DT, Zubieta JK, Love TM, Oxytocin modulates hemodynamic responses to monetary incentives in humans. Psychopharmacology (Berl) 2016 Dec;233(23-24):3905-3919

Haq AU, Mickey BJ, Drs Haq and Mickey Reply. J Clin Psychiatry 2016 Jul;77(7):e905

Mickey BJ, Genetic variation and the D2 dopamine receptor: implications for the treatment of neuropsychiatric disease. Pharmacogenomics 2016 Jul;17(11):1207-1210

Tadayonnejad R, Ajilore O, Mickey BJ, Crane NA, Hsu DT, Kumar A, Zubieta JK, Langenecker SA, Pharmacological modulation of pulvinar resting-state regional oscillations and network dynamics in major depression. Psychiatry Res 2016 Apr 27;252:10-18

Jacobs RH, Barba A, Gowins JR, Klumpp H, Jenkins LM, Mickey BJ, Ajilore O, Peciņa M, Sikora M, Ryan KA, Hsu DT, Welsh RC, Zubieta JK, Phan KL, Langenecker SA, Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder. Psychol Med 2016 Apr;46(5):1055-67

Gluskin BS, Mickey BJ, Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies. Transl Psychiatry 2016 Mar 1;6:e747

Sikora M, Heffernan J, Avery ET, Mickey BJ, Zubieta JK, Peciņa M, Salience Network Functional Connectivity Predicts Placebo Effects in Major Depression. Biol Psychiatry Cogn Neurosci Neuroimaging 2016 Jan;1(1):68-76

Peciņa M, Bohnert AS, Sikora M, Avery ET, Langenecker SA, Mickey BJ, Zubieta JK, Association Between Placebo-Activated Neural Systems and Antidepressant Responses: Neurochemistry of Placebo Effects in Major Depression. JAMA Psychiatry 2015 Nov;72(11):1087-94

DelDonno SR, Weldon AL, Crane NA, Passarotti AM, Pruitt PJ, Gabriel LB, Yau W, Meyers KK, Hsu DT, Taylor SF, Heitzeg MM, Herbener E, Shankman SA, Mickey BJ, Zubieta JK, Langenecker SA, Affective personality predictors of disrupted reward learning and pursuit in major depressive disorder. Psychiatry Res 2015 Nov 30;230(1):56-64

Haq AU, Sitzmann AF, Goldman ML, Maixner DF, Mickey BJ, Response of depression to electroconvulsive therapy: a meta-analysis of clinical predictors. J Clin Psychiatry 2015 Oct;76(10):1374-84

Hsu DT, Sanford BJ, Meyers KK, Love TM, Hazlett KE, Walker SJ, Mickey BJ, Koeppe RA, Langenecker SA, Zubieta JK, It still hurts: altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder. Mol Psychiatry 2015 Feb;20(2):193-200

Glaser YG, Zubieta JK, Hsu DT, Villafuerte S, Mickey BJ, Trucco EM, Burmeister M, Zucker RA, Heitzeg MM, Indirect effect of corticotropin-releasing hormone receptor 1 gene variation on negative emotionality and alcohol use via right ventrolateral prefrontal cortex. J Neurosci 2014 Mar 12;34(11):4099-107

Lohoff FW, Hodge R, Narasimhan S, Nall A, Ferraro TN, Mickey BJ, Heitzeg MM, Langenecker SA, Zubieta JK, Bogdan R, Nikolova YS, Drabant E, Hariri AR, Bevilacqua L, Goldman D, Doyle GA, Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing. Mol Psychiatry 2014 Jan;19(1):129-39

Hsu DT, Sanford BJ, Meyers KK, Love TM, Hazlett KE, Wang H, Ni L, Walker SJ, Mickey BJ, Korycinski ST, Koeppe RA, Crocker JK, Langenecker SA, Zubieta JK, Social feedback activates the endogenous opioid system. Mol Psychiatry 2013 Nov;18(11):1147

Hsu DT, Sanford BJ, Meyers KK, Love TM, Hazlett KE, Wang H, Ni L, Walker SJ, Mickey BJ, Korycinski ST, Koeppe RA, Crocker JK, Langenecker SA, Zubieta JK, Response of the ĩ-opioid system to social rejection and acceptance. Mol Psychiatry 2013 Nov;18(11):1211-7

Peciņa M, Mickey BJ, Love T, Wang H, Langenecker SA, Hodgkinson C, Shen PH, Villafuerte S, Hsu D, Weisenbach SL, Stohler CS, Goldman D, Zubieta JK, DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience. Cortex 2013 Mar;49(3):877-90

Love TM, Enoch MA, Hodgkinson CA, Peciņa M, Mickey B, Koeppe RA, Stohler CS, Goldman D, Zubieta JK, Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner. Biol Psychiatry 2012 Aug 1;72(3):198-206

Mickey BJ, Sanford BJ, Love TM, Shen PH, Hodgkinson CA, Stohler CS, Goldman D, Zubieta JK, Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans. J Neurosci 2012 Jul 4;32(27):9344-50

Hsu DT, Mickey BJ, Langenecker SA, Heitzeg MM, Love TM, Wang H, Kennedy SE, Peciņa M, Shafir T, Hodgkinson CA, Enoch MA, Goldman D, Zubieta JK, Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing. J Neurosci 2012 Feb 29;32(9):3253-60

Mickey BJ, Zhou Z, Heitzeg MM, Heinz E, Hodgkinson CA, Hsu DT, Langenecker SA, Love TM, Peciņa M, Shafir T, Stohler CS, Goldman D, Zubieta JK, Emotion processing, major depression, and functional genetic variation of neuropeptide Y. Arch Gen Psychiatry 2011 Feb;68(2):158-66

Mickey BJ, Ducci F, Hodgkinson CA, Langenecker SA, Goldman D, Zubieta JK, Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo. J Neurosci 2008 Oct 29;28(44):11354-9

Mickey BJ, Middlebrooks JC, Sensitivity of auditory cortical neurons to the locations of leading and lagging sounds. J Neurophysiol 2005 Aug;94(2):979-89

Mickey BJ, Dalack GW, Auditory gating in schizophrenia: a pilot study of the precedence effect. Schizophr Res 2005 Mar 1;73(2-3):327-31

Mickey BJ, Middlebrooks JC, Representation of auditory space by cortical neurons in awake cats. J Neurosci 2003 Sep 24;23(25):8649-63

Stecker GC, Mickey BJ, Macpherson EA, Middlebrooks JC, Spatial sensitivity in field PAF of cat auditory cortex. J Neurophysiol 2003 Jun;89(6):2889-903

Mickey BJ, Middlebrooks JC, Responses of auditory cortical neurons to pairs of sounds: correlates of fusion and localization. J Neurophysiol 2001 Sep;86(3):1333-50