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Alexey V Zaitsev
E-mail:

Phone: 801-587-5834
Office: CVRTI Rm 235

Alexey V Zaitsev



Research

Mechanisms of cardiac arrhythmias; myocardial ischemia; real-time physiological imaging of single cardiac myocytes and whole hearts


Current Research

The current focus of Dr. Zaitsev's group is the mechanisms of ventricular fibrillation in normal and ischemic hearts.

Active Grants
PI “Ventricular Fibrillation in a Globally Ischemic Heart: From Cell to ECG” (NIH R01 HL088444-01A1)
PI "Mechanisms of Asystole and Contractile Dysfunction in an Experimental Model of Sudden Cardiac Arrest" (Nora Eccles Treadwell Foundation Research Grant)


Selected Publications

Warren M, Sciuto KJ, Taylor TG, Garg V, Torres NS, Shibayama J, Spitzer KW, Zaitsev AV, Blockade of CaMKII Depresses Conduction Preferentially in the Right Ventricular Outflow Tract and Promotes Ischemic Ventricular Fibrillation in the Rabbit Heart. Am J Physiol Heart Circ Physiol 2017 Jan 27;:ajpheart.00347.2016

Garg V, Taylor T, Warren M, Venable P, Sciuto K, Shibayama J, Zaitsev A, ß-Adrenergic stimulation and rapid pacing mutually promote heterogeneous electrical failure and ventricular fibrillation in the globally ischemic heart. Am J Physiol Heart Circ Physiol 2015 May 1;308(9):H1155-70

Venable PW, Sciuto KJ, Warren M, Taylor TG, Garg V, Shibayama J, Zaitsev AV, Mitochondrial depolarization and asystole in the globally ischemic rabbit heart: coordinated response to interventions affecting energy balance. Am J Physiol Heart Circ Physiol 2015 Mar 1;308(5):H485-99

Shibayama J, Yuzyuk TN, Cox J, Makaju A, Miller M, Lichter J, Li H, Leavy JD, Franklin S, Zaitsev AV, Metabolic remodeling in moderate synchronous versus dyssynchronous pacing-induced heart failure: integrated metabolomics and proteomics study. PLoS One 2015 Mar 19;10(3):e0118974

Diakos NA, Selzman CH, Sachse FB, Stehlik J, Kfoury AG, Wever-Pinzon O, Catino A, Alharethi R, Reid BB, Miller DV, Salama M, Zaitsev AV, Shibayama J, Li H, Fang JC, Li DY, Drakos SG, Myocardial atrophy and chronic mechanical unloading of the failing human heart: implications for cardiac assist device-induced myocardial recovery. J Am Coll Cardiol 2014 Oct 14;64(15):1602-12

Taylor TG, Venable PW, Booth A, Garg V, Shibayama J, Zaitsev AV, Does the combination of hyperkalemia and KATP activation determine excitation rate gradient and electrical failure in the globally ischemic fibrillating heart? Am J Physiol Heart Circ Physiol 2013 Sep 15;305(6):H903-12

Venable PW, Taylor TG, Sciuto KJ, Zhao J, Shibayama J, Warren M, Spitzer KW, Zaitsev AV, Detection of mitochondrial depolarization/recovery during ischaemia--reperfusion using spectral properties of confocally recorded TMRM fluorescence. J Physiol 2013 Jun 1;591(11):2781-94

Shibayama J, Taylor TG, Venable PW, Rhodes NL, Gil RB, Warren M, Wende AR, Abel ED, Cox J, Spitzer KW, Zaitsev AV, Metabolic determinants of electrical failure in ex-vivo canine model of cardiac arrest: evidence for the protective role of inorganic pyrophosphate. PLoS One 2013;8(3):e57821

Taylor TG, Venable PW, Shibayama J, Warren M, Zaitsev AV, Role of KATP channel in electrical depression and asystole during long-duration ventricular fibrillation in ex vivo canine heart. Am J Physiol Heart Circ Physiol 2012 Jun 1;302(11):H2396-409

Venable PW, Taylor TG, Shibayama J, Warren M, Zaitsev AV, Complex structure of electrophysiological gradients emerging during long-duration ventricular fibrillation in the canine heart. Am J Physiol Heart Circ Physiol 2010 Nov;299(5):H1405-18

Warren M, Spitzer KW, Steadman BW, Rees TD, Venable P, Taylor T, Shibayama J, Yan P, Wuskell JP, Loew LM, Zaitsev AV, High-precision recording of the action potential in isolated cardiomyocytes using the near-infrared fluorescent dye di-4-ANBDQBS. Am J Physiol Heart Circ Physiol 2010 Oct;299(4):H1271-81

Wasmund SL, Pai RK, Freedman RA, Abedin M, Daccarett M, Segerson NM, Zaitsev AV, Hamdan MH, Modulation of the sinus rate during ventricular fibrillation. J Cardiovasc Electrophysiol 2009 Feb;20(2):187-92

Shvedko AG, Warren MD, Shome S, Stinstra J, Zaitsev AV, Influence of the skeletal muscle activity on time and frequency domain properties of the body surface ECG during evolving ventricular fibrillation in the pig. Resuscitation 2008 Aug;78(2):215-23

Matiukas A, Mitrea BG, Qin M, Pertsov AM, Shvedko AG, Warren MD, Zaitsev AV, Wuskell JP, Wei MD, Watras J, Loew LM, Near-infrared voltage-sensitive fluorescent dyes optimized for optical mapping in blood-perfused myocardium. Heart Rhythm 2007 Nov;4(11):1441-51

Warren M, Huizar JF, Shvedko AG, Zaitsev AV, Spatiotemporal relationship between intracellular Ca2+ dynamics and wave fragmentation during ventricular fibrillation in isolated blood-perfused pig hearts. Circ Res 2007 Oct 26;101(9):e90-101

Tanaka K, Zlochiver S, Vikstrom KL, Yamazaki M, Moreno J, Klos M, Zaitsev AV, Vaidyanathan R, Auerbach DS, Landas S, Guiraudon G, Jalife J, Berenfeld O, Kalifa J, Spatial distribution of fibrosis governs fibrillation wave dynamics in the posterior left atrium during heart failure. Circ Res 2007 Oct 12;101(8):839-47

Huizar JF, Warren MD, Shvedko AG, Kalifa J, Moreno J, Mironov S, Jalife J, Zaitsev A , Three distinct phases of VF during global ischemia in the isolated blood-perfused pig heart. Am J Physiol Heart Circ Physiol 2007 Sep;293(3):H1617-28