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Sarang  Joshi

Phone: 801-587-7961
Phone: 801-585-6513
Office: WEB 3692

Sarang Joshi

D.Sc. in Electrical Engineering from Washington University in St. Louis.


Image Understanding, Computer Vision and Shape Analysis.

Current Research

Dr. Sarang Joshi joined SCI as an Associate Professor of the Department of Bio Engineering in 2006. Before coming to Utah, Dr. Joshi was an Assistant Professor of Radiation Oncology and an Adjunct Assistant Professor of Computer Science at the University of North Carolina in Chapel Hill. Prior to joining Chapel Hill Dr. Joshi was Director of Technology Development at IntellX, a Medical Imaging start-up company which was later acquired by Medtronic. Sarang’s research interests are in the field of Computational Anatomy. The principal aim of computational anatomy is the development of specialized mathematical and computational tools for the precise study of anatomical variability and the application of these tools for improved medical treatment, diagnosis and understanding of disease. In 2005 he spent a year on sabbatical at DKFZ (German Cancer Research Center) in Heidelberg, Germany, as a visiting scientist in the Department of Medical Physics where he focused on developing four dimensional radiation therapy approaches for improved treatment of Prostate and Lung Cancer. He was also one of the founding partner of Morphormics, Inc. which was recently acquired by Accuray. He has won numerous awards including the 2007 David Marr Best Paper Award, The international journal Signal Processing 2010 Most cited paper Award, and MICCAI 2010 Best of the Journal Issue Award.
He holds numerous patents in the area of image registration and segmentation.

Selected Publications

Durrleman S, Prastawa M, Charon N, Korenberg JR, Joshi S, Gerig G, Trouvé A, Morphometry of anatomical shape complexes with dense deformations and sparse parameters. Neuroimage 2014 Nov 1;101:35-49

Singh N, Fletcher PT, Preston JS, King RD, Marron JS, Weiner MW, Joshi S, Quantifying anatomical shape variations in neurological disorders. Med Image Anal 2014 Apr;18(3):616-33

Tosun D, Joshi S, Weiner MW, Multimodal MRI-based Imputation of the Aß+ in Early Mild Cognitive Impairment. Ann Clin Transl Neurol 2014 Mar;1(3):160-170

Sarkar V, Wang B, Hinkle J, Gonzalez VJ, Hitchcock YJ, Rassiah-Szegedi P, Joshi S, Salter BJ, Dosimetric evaluation of a "virtual" image-guidance alternative to explicit 6 degree of freedom robotic couch correction. Pract Radiat Oncol 2012 Apr-Jun;2(2):122-37

Sawant A, Keall P, Pauly KB, Alley M, Vasanawala S, Loo BW Jr, Hinkle J, Joshi S, Investigating the feasibility of rapid MRI for image-guided motion management in lung cancer radiotherapy. Biomed Res Int 2014;2014:485067


Cardenas VA, Tosun D, Chao LL, Fletcher PT, Joshi S, Weiner MW, Schuff N, Voxel-Wise Co-analysis of Macro- and Microstructural Brain Alteration in Mild Cognitive Impairment and Alzheimer's Disease Using Anatomical and Diffusion MRI. J Neuroimaging 2013 Feb 19;:

Szegedi M, Hinkle J, Rassiah P, Sarkar V, Wang B, Joshi S, Salter B, Four-dimensional tissue deformation reconstruction (4D TDR) validation using a real tissue phantom. J Appl Clin Med Phys 2013 Jan 7;14(1):4012

Szegedi M, Rassiah-Szegedi P, Sarkar V, Hinkle J, Wang B, Huang YH, Zhao H, Joshi S, Salter BJ, Tissue characterization using a phantom to validate four-dimensional tissue deformation. Med Phys 2012 Oct;39(10):6065-70

Hinkle J, Szegedi M, Wang B, Salter B, Joshi S, 4D CT image reconstruction with diffeomorphic motion model. Med Image Anal 2012 Aug;16(6):1307-16

Ha LK, Krüger J, Dihl Comba JL, Silva CT, Joshi S, ISP: an optimal out-of-core image-set processing streaming architecture for parallel heterogeneous systems. IEEE Trans Vis Comput Graph 2012 Jun;18(6):838-51

Singh N, Wang AY, Sankaranarayanan P, Fletcher PT, Joshi S, Genetic, structural and functional imaging biomarkers for early detection of conversion from MCI to AD. Med Image Comput Comput Assist Interv 2012;15(Pt 1):132-40

Geneser SE, Hinkle JD, Kirby RM, Wang B, Salter B, Joshi S, Quantifying variability in radiation dose due to respiratory-induced tumor motion. Med Image Anal 2011 Aug;15(4):640-9

Ha L, Prastawa M, Gerig G, Gilmore JH, Silva CT, Joshi S, Efficient Probabilistic and Geometric Anatomical Mapping Using Particle Mesh Approximation on GPUs. Int J Biomed Imaging 2011;2011:572187

Jiao F, Gur Y, Johnson CR, Joshi S, Detection of crossing white matter fibers with high-order tensors and rank-k decompositions. Inf Process Med Imaging 2011;22:538-49

Durrleman S, Prastawa M, Gerig G, Joshi S, Optimal data-driven sparse parameterization of diffeomorphisms for population analysis. Inf Process Med Imaging 2011;22:123-34

Jiao F, Gur Y, Johnson CR, Joshi S, Detection of crossing white matter fibers with high-order tensors and rank-k decompositions. Inf Process Med Imaging 2011;6801:538-549

Gerber S, Tasdizen T, Thomas Fletcher P, Joshi S, Whitaker R, Manifold modeling for brain population analysis. Med Image Anal 2010 Oct;14(5):643-53

Singh N, Fletcher PT, Preston JS, Ha L, King R, Marron JS, Wiener M, Joshi S, Multivariate statistical analysis of deformation momenta relating anatomical shape to neuropsychological measures. Med Image Comput Comput Assist Interv 2010;13(Pt 3):529-37

Ha L, Prastawa M, Gerig G, Gilmore JH, Silva CT, Joshi S, Image registration driven by combined probabilistic and geometric descriptors. Med Image Comput Comput Assist Interv 2010;13(Pt 2):602-9

Henninger HB, Maas SA, Shepherd JH, Joshi S, Weiss JA, Transversely isotropic distribution of sulfated glycosaminoglycans in human medial collateral ligament: a quantitative analysis. J Struct Biol 2009 Mar;165(3):176-83

Fletcher PT, Venkatasubramanian S, Joshi S, The geometric median on Riemannian manifolds with application to robust atlas estimation. Neuroimage 2009 Mar;45(1 Suppl):S143-52

Gerber S, Tasdizen T, Joshi S, Whitaker R, On the manifold structure of the space of brain images. Med Image Comput Comput Assist Interv 2009;12(Pt 1):305-12

Geneser SE, Kirby RM, Wang B, Salter B, Joshi S, Incorporating patient breathing variability into a stochastic model of dose deposition for stereotactic body radiation therapy. Inf Process Med Imaging 2009;21:688-700

Hinkle J, Fletcher PT, Wang B, Salter B, Joshi S, 4D MAP image reconstruction incorporating organ motion. Inf Process Med Imaging 2009;21:676-87

Wijesooriya K, Weiss E, Dill V, Dong L, Mohan R, Joshi S, Keall PJ, Quantifying the accuracy of automated structure segmentation in 4D CT images using a deformable image registration algorithm. Med Phys 2008 Apr;35(4):1251-60

Terriberry TB, Damon JN, Pizer SM, Joshi SC, Gerig , Population-based fitting of medial shape models with correspondence optimization. Inf Process Med Imaging 2007;20:700-12

Fletcher PT, Powell S, Foster NL, Joshi SC, Quantifying metabolic asymmetry modulo structure in Alzheimer's disease. Inf Process Med Imaging 2007;20:446-57

Corouge I, Fletcher PT, Joshi S, Gouttard S, Gerig , Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis. Med Image Anal 2006 Oct;10(5):786-98

Lorenzen P, Prastawa M, Davis B, Gerig G, Bullitt E, Joshi , Multi-modal image set registration and atlas formation. Med Image Anal 2006 Jun;10(3):440-51

Pevsner A, Davis B, Joshi S, Hertanto A, Mechalakos J, Yorke E, Rosenzweig K, Nehmeh S, Erdi YE, Humm JL, Larson S, Ling CC, Mageras G , Evaluation of an automated deformable image matching method for quantifying lung motion in respiration-correlated CT images. Med Phys 2006 Feb;33(2):369-76

Foskey M, Davis B, Goyal L, Chang S, Chaney E, Strehl N, Tomei S, Rosenman J, Joshi , Large deformation three-dimensional image registration in image-guided radiation therapy. Phys Med Biol 2005 Dec 21;50(24):5869-92

Bullitt E, Zeng D, Gerig G, Aylward S, Joshi S, Smith JK, Lin W, Ewend M , Vessel tortuosity and brain tumor malignancy: a blinded study. Acad Radiol 2005 Oct;12(10):1232-40

Pizer SM, Fletcher PT, Joshi S, Gash AG, Stough J, Thall A, Tracton G, Chaney E , A method and software for segmentation of anatomic object ensembles by deformable m-reps. Med Phys 2005 May;32(5):1335-45

Keall PJ, Joshi S, Vedam SS, Siebers JV, Kini VR, Mohan , Four-dimensional radiotherapy planning for DMLC-based respiratory motion tracking. Med Phys 2005 Apr;32(4):942-51

Lorenzen P, Davis B, Joshi , Unbiased atlas formation via large deformations metric mapping. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2005;8(Pt 2):411-8

Corouge I, Fletcher PT, Joshi S, Gilmore JH, Gerig , Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2005;8(Pt 1):131-9

Terriberry TB, Joshi SC, Gerig , Hypothesis testing with nonlinear shape models. Inf Process Med Imaging 2005;19:15-26

Guo H, Rangarajan A, Joshi S , 3-D diffeomorphic shape registration on hippocampal data sets. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 2005;8(Pt 2):984-91

Bullitt E, Ewend MG, Aylward S, Lin W, Gerig G, Joshi S, Jung I, Muller K, Smith J , Abnormal vessel tortuosity as a marker of treatment response of malignant gliomas: preliminary report. Technol Cancer Res Treat 2004 Dec;3(6):577-84

Fletcher PT, Lu C, Pizer SM, Joshi , Principal geodesic analysis for the study of nonlinear statistics of shape. IEEE Trans Med Imaging 2004 Aug;23(8):995-1005

Csernansky JG, Wang L, Joshi SC, Ratnanather JT, Miller M , Computational anatomy and neuropsychiatric disease: probabilistic assessment of variation and statistical inference of group difference, hemispheric asymmetry, and time-dependent change. Neuroimage 2004;23 Suppl 1:S56-68

Joshi S, Davis B, Jomier M, Gerig , Unbiased diffeomorphic atlas construction for computational anatomy. Neuroimage 2004;23 Suppl 1:S151-60

Yushkevich P, Joshi S, Pizer SM, Csernansky JG, Wang L , Feature selection for shape-based classification of biological objects. Inf Process Med Imaging 2003 Jul;18:114-25

Fletcher PT, Joshi S, Lu C, Pizer , Gaussian distributions on Lie groups and their application to statistical shape analysis. Inf Process Med Imaging 2003 Jul;18:450-62

Hogan RE, Bucholz RD, Joshi , Hippocampal deformation-based shape analysis in epilepsy and unilateral mesial temporal sclerosis. Epilepsia 2003 Jun;44(6):800-6

Joshi S, Lorenzen P, Gerig G, Bullitt , Structural and radiometric asymmetry in brain images. Med Image Anal 2003 Jun;7(2):155-70

Joshi S, Pizer S, Fletcher PT, Yushkevich P, Thall A, Marron J , Multiscale deformable model segmentation and statistical shape analysis using medial descriptions. IEEE Trans Med Imaging 2002 May;21(5):538-50

Wang L, Joshi SC, Miller MI, Csernansky J , Statistical analysis of hippocampal asymmetry in schizophrenia. Neuroimage 2001 Sep;14(3):531-45

Csernansky JG, Wang L, Joshi S, Miller JP, Gado M, Kido D, McKeel D, Morris JC, Miller M , Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus. Dementia of the Alzheimer type. Neurology 2000 Dec 12;55(11):1636-43

Hogan RE, Mark KE, Wang L, Joshi S, Miller MI, Bucholz R , Mesial temporal sclerosis and temporal lobe epilepsy: MR imaging deformation-based segmentation of the hippocampus in five patients. Radiology 2000 Jul;216(1):291-7

Hogan RE, Mark KE, Choudhuri I, Wang L, Joshi S, Miller MI, Bucholz R , Magnetic resonance imaging deformation-based segmentation of the hippocampus in patients with mesial temporal sclerosis and temporal lobe epilepsy. J Digit Imaging 2000 May;13(2 Suppl 1):217-8

Van Essen DC, Drury HA, Joshi S, Miller M , Functional and structural mapping of human cerebral cortex: solutions are in the surfaces. Adv Neurol 2000;84:23-34

Joshi M, Cui J, Doolittle K, Joshi S, Van Essen D, Wang L, Miller M , Brain segmentation and the generation of cortical surfaces. Neuroimage 1999 May;9(5):461-76

Csernansky JG, Joshi S, Wang L, Haller JW, Gado M, Miller JP, Grenander U, Miller M , Hippocampal morphometry in schizophrenia by high dimensional brain mapping. Proc Natl Acad Sci U S A 1998 Sep 15;95(19):11406-11

Van Essen DC, Drury HA, Joshi S, Miller M , Functional and structural mapping of human cerebral cortex: solutions are in the surfaces. Proc Natl Acad Sci U S A 1998 Feb 3;95(3):788-95

Christensen GE, Joshi SC, Miller M , Volumetric transformation of brain anatomy. IEEE Trans Med Imaging 1997 Dec;16(6):864-77

Miller M, Banerjee A, Christensen G, Joshi S, Khaneja N, Grenander U, Matejic , Statistical methods in computational anatomy. Stat Methods Med Res 1997 Sep;6(3):267-99

Levy AL, Schaewe TJ, Miller MI, Smith KR, Hammoud AM, Henderson JM, Joshi S, Mark KE, Sturm CD, McDurmont LL Jr, Bucholz R , An Internet-connected, patient-specific, deformable brain atlas integrated into a surgical navigation system. J Digit Imaging 1997 Aug;10(3 Suppl 1):231-7

Haller JW, Banerjee A, Christensen GE, Gado M, Joshi S, Miller MI, Sheline Y, Vannier MW, Csernansky J , Three-dimensional hippocampal MR morphometry with high-dimensional transformation of a neuroanatomic atlas. Radiology 1997 Feb;202(2):504-10

Haller JW, Christensen GE, Joshi SC, Newcomer JW, Miller MI, Csernansky JG, Vannier M , Hippocampal MR imaging morphometry by means of general pattern matching. Radiology 1996 Jun;199(3):787-91

Joshi S, Miller M , Maximum a posteriori estimation with Good's roughness for three-dimensional optical-sectioning microscopy. J Opt Soc Am A 1993 May;10(5):1078-85