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Bradley  Greger

Bradley Greger

Assistant Professor
Advisor, Bioengineering Honors
Adjunct Asst. Professor Ophthalmology and Electrical & Computer Engineering
Postdoctoral Fellow, Caltech (2006)
Ph.D. Neuroscience, Washington University in St. Louis (2001)
BS Biology, Washington State University (1995)
BA Philosophy, Washington State University (1994)

E-mail:


Phone: 801-585-5795


Research

Neural Engineering & Systems Neuroscience


Current Research

Research in the Neural Engineering Lab focuses on understanding how information is encoded in neural structures and on how to apply this understanding to the treatment of human pathology. Electrophysiological recordings and electrical micro-stimulation are used to gain an understanding of how the nervous system processes information related to various sensory, motor, and cognitive functions. The results of these experiments are then used to guide implementation of neural prostheses for human patients. Neural prosthesis for the profoundly blind and amputees are currently being developed in the lab. Electrophysiological research in humans aimed at understanding and treating epilepsy is also ongoing in the lab. All of this work utilizes the high-channel count micro-electrode array technology for interfacing with the nervous system.


Selected Publications

Smith E, Kellis S, House P, Greger B, Decoding stimulus identity from multi-unit activity and local field potentials along the ventral auditory stream in the awake primate: implications for cortical neural prostheses. J Neural Eng 2013 Feb;10(1):016010

Hanrahan SJ, Greger B, Parker RA, Ogura T, Obara S, Egan TD, House PA, The effects of propofol on local field potential spectra, action potential firing rate, and their temporal relationship in humans and felines. Front Hum Neurosci 2013;7():136

Davis TS, Parker RA, House PA, Bagley E, Wendelken S, Normann RA, Greger B, Spatial and temporal characteristics of V1 microstimulation during chronic implantation of a microelectrode array in a behaving macaque. J Neural Eng 2012 Dec;9(6):065003

Egan J, Baker J, House PA, Greger B, Decoding dexterous finger movements in a neural prosthesis model approaching real-world conditions. IEEE Trans Neural Syst Rehabil Eng 2012 Nov;20(6):836-44

Smith EH, Kellis SS, House PA, Greger B, Information transfer along the ventral auditory processing stream in the awake macaque. Conf Proc IEEE Eng Med Biol Soc 2012;2012():5178-81

Parker RA, Negi S, Davis T, Keefer EW, Wiggins H, House PA, Greger B, The use of a novel carbon nanotube coated microelectrode array for chronic intracortical recording and microstimulation. Conf Proc IEEE Eng Med Biol Soc 2012;2012():791-4

Torab K, Davis TS, Warren DJ, House PA, Normann RA, Greger B, Multiple factors may influence the performance of a visual prosthesis based on intracortical microstimulation: nonhuman primate behavioural experimentation. J Neural Eng 2011 Jun;8(3):035001

Egan J, Baker J, House P, Greger B, Detection and classification of multiple finger movements using a chronically implanted Utah Electrode Array. Conf Proc IEEE Eng Med Biol Soc 2011;2011():7320-3

Parker RA, Davis TS, House PA, Normann RA, Greger B, The functional consequences of chronic, physiologically effective intracortical microstimulation. Prog Brain Res 2011;194():145-65

Kellis S, Greger B, Hanrahan S, House P, Brown R, Platinum microwire for subdural electrocorticography over human neocortex: millimeter-scale spatiotemporal dynamics. Conf Proc IEEE Eng Med Biol Soc 2011;2011():4761-5

Kellis S, Miller K, Thomson K, Brown R, House P, Greger B, Decoding spoken words using local field potentials recorded from the cortical surface. J Neural Eng 2010 Oct;7(5):056007

Baker JJ, Scheme E, Englehart K, Hutchinson DT, Greger B, Continuous detection and decoding of dexterous finger flexions with implantable myoelectric sensors. IEEE Trans Neural Syst Rehabil Eng 2010 Aug;18(4):424-32

Kellis S, Miller K, Thomson K, Brown R, House P, Greger B, Classification of spoken words using surface local field potentials. Conf Proc IEEE Eng Med Biol Soc 2010;2010():3827-30

Harrison RR, Kier RJ, Chestek CA, Gilja V, Nuyujukian P, Ryu S, Greger B, Solzbacher F, Shenoy KV, Wireless neural recording with single low-power integrated circuit. IEEE Trans Neural Syst Rehabil Eng 2009 Aug;17(4):322-9

Kellis SS, House PA, Thomson KE, Brown R, Greger B, Human neocortical electrical activity recorded on nonpenetrating microwire arrays: applicability for neuroprostheses. Neurosurg Focus 2009 Jul;27(1):E9

Normann RA, Greger B, House P, Romero SF, Pelayo F, Fernandez E, Toward the development of a cortically based visual neuroprosthesis. J Neural Eng 2009 Jun;6(3):035001

Davis TS, Torab K, House P, Greger B, A minimally invasive approach to long-term head fixation in behaving nonhuman primates. J Neurosci Methods 2009 Jun 30;181(1):106-10

Lehmkuhle MJ, Thomson KE, Scheerlinck P, Pouliot W, Greger B, Dudek FE, A simple quantitative method for analyzing electrographic status epilepticus in rats. J Neurophysiol 2009 Mar;101(3):1660-70

Baker J, Bishop W, Kellis S, Levy T, House P, Greger B, Multi-scale recordings for neuroprosthetic control of finger movements. Conf Proc IEEE Eng Med Biol Soc 2009;2009():4573-7

Hakimian S, Norris SA, Greger B, Keating JG, Anderson CH, Thach WT, Time and frequency characteristics of Purkinje cell complex spikes in the awake monkey performing a nonperiodic task. J Neurophysiol 2008 Aug;100(2):1032-40

Baker JJ, Yatsenko D, Schorsch JF, DeMichele GA, Troyk PR, Hutchinson DT, Weir RF, Clark G, Greger B, Decoding individuated finger flexions with Implantable MyoElectric Sensors. Conf Proc IEEE Eng Med Biol Soc 2008;2008():193-6

Greger B, Kateb B, Gruen P, Patterson PH, A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals. J Neurosci Methods 2007 Jul 30;163(2):321-5

Greger B, Norris S, Simple spike firing in the posterior lateral cerebellar cortex of Macaque Mulatta was correlated with success-failure during a visually guided reaching task. Exp Brain Res 2005 Dec;167(4):660-5

Cham JG, Branchaud EA, Nenadic Z, Greger B, Andersen RA, Burdick J , Semi-chronic motorized microdrive and control algorithm for autonomously isolating and maintaining optimal extracellular action potentials. J Neurophysiol 2005 Jan;93(1):570-9

Norris SA, Greger B, Hathaway EN, Thach W , Purkinje cell spike firing in the posterolateral cerebellum: correlation with visual stimulus, oculomotor response, and error feedback. J Neurophysiol 2004 Sep;92(3):1867-79

Musallam S, Corneil BD, Greger B, Scherberger H, Andersen R , Cognitive control signals for neural prosthetics. Science 2004 Jul 9;305(5681):258-62

Andersen RA, Burdick JW, Musallam S, Scherberger H, Pesaran B, Meeker D, Corneil BD, Fineman I, Nenadic Z, Branchaud E, Cham JG, Greger B, Tai YC, Mojarradi MM, Recording advances for neural prosthetics. Conf Proc IEEE Eng Med Biol Soc 2004;7():5352-5

Greger B, Norris SA, Thach W , Spike firing in the lateral cerebellar cortex correlated with movement and motor parameters irrespective of the effector limb. J Neurophysiol 2004 Jan;91(1):576-82

Rizzuto DS, Breznen B, Greger , Military-funded research is not unethical. Nature 2003 Jul 24;424(6947):369

Martin TA, Norris SA, Greger BE, Thach W , Dynamic coordination of body parts during prism adaptation. J Neurophysiol 2002 Oct;88(4):1685-94

Norris SA, Greger BE, Martin TA, Thach WT, Prism adaptation of reaching is dependent on the type of visual feedback of hand and target position. Brain Res 2001 Jun 29;905(1-2):207-19

Martin TA, Greger BE, Norris SA, Thach WT, Throwing accuracy in the vertical direction during prism adaptation: not simply timing of ball release. J Neurophysiol 2001 May;85(5):2298-302

Li CP, Olavarria JF, Greger BE, Occipital cortico-pyramidal projection in hypothyroid rats. Brain Res Dev Brain Res 1995 Nov 21;89(2):227-34