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David W. Grainger
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Phone: 801 585 3715
Phone: 801 585 7824
Office: 301 Skaggs; 190D BPRB; Health Sciences Campus

David W. Grainger

Professor
• University Distinguished Professor and Chair, Pharmaceutics and Pharmaceutical Chemistry
• Inaugural George S. & Dolores Doré Eccles Presidential Endowed Chair of Pharmaceutics and Pharmaceutical Chemistry
• Excellence in Surface Science Award, Surfaces in Biomaterials Foundation, 2013
• University of Utah Distinguished Graduate and Post Doctoral Scholar Mentor Award, 2010
• Elected Fellow, American Association for the Advancement of Science, 2008
• Clem
Alexander von Humboldt Postdoctoral Fellow, University of Mainz, Germany, 1989
Ph.D., Pharmaceutics, University of Utah, 1987
B.A., Engineering modified with Chemistry, Dartmouth College, 1983



Research

Drug delivery and medical device innovation; bioanalytical sensing, diagnostics and microarrays, foreign body response, device infection and bacterial-surface interactions, drug delivery, antibody drugs, novel vaccines


Current Research

Research Areas:

• Drug delivery systems and novel formulation strategies
• Polymeric biomaterials
• Antimicrobial medical devices, infection and bacterial colonization
• Nucleic acid and protein microarray diagnostics
• Macrophage interactions with biomaterials and the foreign body response
• Novel live vaccine and protein delivery
• Bioanalytical sensing and device miniaturization

New Technical Book Chapters:

1. M.N. Avula, D.W. Grainger, “Addressing medical device challenges with drug/device combinations,” Chapter 3, in Drug-Device Combinations for Chronic Diseases, R. Siegel., S.P. Lyu, eds., Wiley, New York, in press, 2013.
2. C.F. Jones, D.G. Castner, D.W. Grainger, “Surface Adsorbate Processing on Nanomaterials in Host Immune and Toxicological Processing”, in Immunological properties of engineered nanomaterials, (M. Dubrovolaskia, ed.), World Scientific Press, Singapore, 2013, DOI 10.1142/9789814390262_0005.
3. B. Brooks, A. Brooks. D.W. Grainger, “Antimicrobial Technologies in Preclinical and Clinical Medical Devices”, in ‪Biomaterials Associated Infection‬: ‪Immunological Aspects and Antimicrobial Strategies‬, T. F. Moriarty, S.A.J. Zaat, H. Busscher, eds., Springer Verlag, New York, 2012, Chapter 13, pp. 307-354; ISBN 978-1-4614-1030-0.‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬
4. F. Liu, D.W. Grainger, “Fluorinated Biomaterials” in Biomaterials Science, 3rd ed., B.D. Ratner, A.S. Hoffman, J. Lemons, F. Schoen, eds., Academic Elsevier, Amsterdam, 2013, pp. 92-103 (Chapter 1.1.2c) ISBN-10: 0123746264, ISBN-13: 978-0123746269.
5. A. Nel, D.W. Grainger, P.J. Alvarez, S. Badesha, V. Castranova, M. Ferrari, H. Godwin, P. Grodzinski, J. Morris, N. Savage, N. Scott, M. Wiesner, “Nanotechnology Environmental, Health, and Safety Issues,” Chapter 4 in: Nanotechnology Research Directions for Societal Needs in 2020: Retrospective and Outlook (M.C. Roco, C.A. Mirkin, M.C. Hersam, eds.) NSF/WTEC report, 2011,
Springer, Boston, USA, pp. 610.
6. F. Liu, D.W. Grainger, “Fluorinated Biomaterials” in Comprehensive Biomaterials vol 1, Chapter 128, eds. P. Ducheyne, K. Healy, D.W. Grainger, J. Kirkpatrick, D. Hutmacher, Elsevier, Amsterdam (ISBN 978-0-08-055302-3), 2011, pp 513-525.
7. D.G. Castner, D.W. Grainger, “Surface analytical methods: in situ and UHV techniques” in Comprehensive Biomaterials – vol 3, chapter 301, eds. P. Ducheyne, K. Healy, D.W. Grainger, J. Kirkpatrick, D. Hutmacher, Elsevier, Amsterdam (ISBN 978-0-08-055302-3), 2011, pp 1-22.
8. D. Holt, D.W. Grainger, “Chapter 6: Host-Implant Response”, in An Introduction to Biomaterials, 2nd ed., (J.O. Hollinger, ed), CRC Press, Boca Raton, FL, ISBN-13: 978-1439812563, (2011).
9. G. Harbers, D.W. Grainger, “Chapter 5: Cell-Materials Interactions: Fundamental Design Issues for Tissue Engineering and Clinical Considerations”, in An Introduction to Biomaterials, 2nd ed. (J.O. Hollinger, ed.), CRC Press, Boca Raton, FL, ISBN-13: 978-1439812563, (2011).
10. J. Veranth, H. Ghandehari, D.W. Grainger, “Nanoparticles in the lung”, in Volume 8 Respiratory Toxicology (G.S. Yost, ed.,), Comprehensive Toxicology series, Elsevier, Oxford, UK, (Chapter 8.23) pp. 453-566 (2010). ISBN 978-0-08-046868-6.
11. C-Y Lee, L.J. Gamble, G.M. Harbers, P. Gong, D.W. Grainger, D.G. Castner, “Multi-technique characterization of DNA-modified surfaces for biosensing and diagnostic applications” in “Surface Analysis and Techniques in Biology”, ed. V. S. Smentkowski, Springer, New York, NY, in press, 2011.
12. M.L. Godek, D.W. Grainger, “The Macrophage in Wound Healing Surrounding Implanted Devices”, in Implantable Glucose Sensing, J. Stenken, D. Cunningham, eds., Wiley, NY, Chapter 2, pp. 18-36, 2009.
13. B. von Rechenberg, L. Meinel, D.W. Grainger, M. Hofman-Amtenbrink, “Introduction to Biotechnology”, in AO Principles of Fracture Management, (2nd ed.), T. Ruedi, ed., AO Publishing, AO Foundation, Davos, Switzerland, pp.47-68, 2007.
14. Gong P, Grainger DW. Nonfouling surfaces: a review of principles and applications for microarray capture assay designs. Methods Mol Biol. 2007;381:59-92. Review. PubMed PMID: 17984514.
15. Grainger DW, Greef CH, Gong P, Lochhead MJ. Current microarray surface chemistries. Methods Mol Biol. 2007;381:37-57. PubMed PMID: 17984513.

Recent research publications not cited in PubMed databases:

• M. Dubey, K. Emoto, H. Takahashi, D.G. Castner, D. W. Grainger, “Affinity-based Protein “Surface Pattern Formation by Ligand Self-Selection from Mixed Protein Solutions”, Adv. Funct. Mater. 19, 3046–3055; doi10.1002/adfm.200900809, (2009).
• H. Takahashi, M. Dubey, K. Emoto, D.G. Castner, D.W. Grainger, “Imaging surface immobilization chemistry: correlation with cell patterning on non-adhesive hydrogel thin films”, Adv. Funct. Mater., 18 1-10 (2008).
• D.W. Grainger, D.G. Castner, “Nanobiomaterials and nanoanalysis: how to improve the nanoscience for biotechnology”, Adv. Mater. 20, 867–877 (2008).
• C. M. Santoro, N.L. Duchsherer, D. W. Grainger, “Minimal antimicrobial efficacy and ocular cell toxicity from silver nanoparticles”, Nanobiotechnology, 10.1007/s12030-008-9007-z, 3:2, 55-65 (2007).
• J.A. Auer, A. Goodship , S. Arnoczky, S. Pearce, J. Price, L. Claes , B. von Rechenberg, M. Hofmann-Amtenbrinck, E. Schneider, R. Muller-Terpitz, F. Thiele, K-P. Rippe, D. W. Grainger, “Refining animal models in fracture research: seeking consensus for optimization of both welfare and scientific validity for appropriate biomedical use”, BMC Musculoskel. Disorders 8:72-78 (2007), doi:10.1186/1471-2474-8-72, published on-line August, 2007.
• G. Harbers, K. Emoto, C. Greef. S. Metzger, D.W. Grainger, M. Lochhead, “A functionalized poly(ethylene glycol) bioassay surface chemistry facilitates bio-immobilization and inhibits non-specific protein, bacterial, and mammalian cell adhesion,” Chem. Mater., 19, 4405-4414 (2007).


Selected Publications

Astashkina AI, Jones CF, Thiagarajan G, Kurtzeborn K, Ghandehari H, Brooks BD, Grainger DW, Nanoparticle toxicity assessment using an in vitro 3-D kidney organoid culture model. Biomaterials 2014 Aug;35(24):6323-31

Brooks BD, Sinclair KD, Davidoff SN, Lawson S, Williams AG, Coats B, Grainger DW, Brooks AE, Molded polymer-coated composite bone void filler improves tobramycin controlled release kinetics. J Biomed Mater Res B Appl Biomater 2014 Jul;102(5):1074-83

Avula MN, Rao AN, McGill LD, Grainger DW, Solzbacher F, Foreign body response to subcutaneous biomaterial implants in a mast cell-deficient Kit(w-Sh) murine model. Acta Biomater 2014 May;10(5):1856-63

Smock KJ, Schmidt RL, Hadlock G, Stoddard G, Grainger DW, Munger MA, Assessment of orally dosed commercial silver nanoparticles on human ex vivo platelet aggregation. Nanotoxicology 2014 May;8(3):328-33

Grainger DW, Cell-based drug testing; this world is not flat. Adv Drug Deliv Rev 2014 Apr;69-70:vii-xi

Astashkina A, Grainger DW, Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments. Adv Drug Deliv Rev 2014 Apr;69-70:1-18

Rao AN, Grainger DW, BIOPHYSICAL PROPERTIES OF NUCLEIC ACIDS AT SURFACES RELEVANT TO MICROARRAY PERFORMANCE. Biomater Sci 2014 Apr 1;2(4):436-471

Silva FJ, Holt DJ, Vargas V, Yockman J, Boudina S, Atkinson D, Grainger DW, Revelo MP, Sherman W, Bull DA, Patel AN, Metabolically active human brown adipose tissue derived stem cells. Stem Cells 2014 Feb;32(2):572-81

Munger MA, Radwanski P, Hadlock GC, Stoddard G, Shaaban A, Falconer J, Grainger DW, Deering-Rice CE, In vivo human time-exposure study of orally dosed commercial silver nanoparticles. Nanomedicine 2014 Jan;10(1):1-9

Wang Y, Liu J, Zhang J, Wang L, Chan J, Wang H, Jin Y, Yu L, Grainger DW, Ying W, A cell-based pharmacokinetics assay for evaluating tubulin-binding drugs. Int J Med Sci 2014;11(5):479-87

Grainger DW, van der Mei HC, Jutte PC, van den Dungen JJ, Schultz MJ, van der Laan BF, Zaat SA, Busscher HJ, Critical factors in the translation of improved antimicrobial strategies for medical implants and devices. Biomaterials 2013 Dec;34(37):9237-43

Bae YH, Grainger DW, The 16th International Symposium on Recent Advances in Drug Delivery, February 3-6, 2013, Salt Lake City, UT, USA. J Control Release 2013 Dec 10;172(2):393-4

Avula MN, Rao AN, McGill LD, Grainger DW, Solzbacher F, Modulation of the foreign body response to implanted sensor models through device-based delivery of the tyrosine kinase inhibitor, masitinib. Biomaterials 2013 Dec;34(38):9737-46

Wang Y, Grainger DW, Developing siRNA therapies to address osteoporosis. Ther Deliv 2013 Oct;4(10):1239-46

Grainger DW, Connecting drug delivery reality to smart materials design. Int J Pharm 2013 Sep 15;454(1):521-4

Grainger DW, All charged up about implanted biomaterials. Nat Biotechnol 2013 Jun;31(6):507-9

Davidoff SN, Lawson ST, Grainger DW, Brooks AE, Scanning electron image analysis to monitor of implant degradation and host healing following implantation of a drug-eluting bone graft void filler - biomed 2013. Biomed Sci Instrum 2013;49:165-71

Richards RG, Moriarty TF, Miclau T, McClellan RT, Grainger DW, Advances in biomaterials and surface technologies. J Orthop Trauma 2012 Dec;26(12):703-7

Rao AN, Vandencasteele N, Gamble LJ, Grainger DW, High-resolution epifluorescence and time-of-flight secondary ion mass spectrometry chemical imaging comparisons of single DNA microarray spots. Anal Chem 2012 Dec 18;84(24):10628-36

Rao AN, Rodesch CK, Grainger DW, Real-time fluorescent image analysis of DNA spot hybridization kinetics to assess microarray spot heterogeneity. Anal Chem 2012 Nov 6;84(21):9379-87

Wang Y, Tran KK, Shen H, Grainger DW, Selective local delivery of RANK siRNA to bone phagocytes using bone augmentation biomaterials. Biomaterials 2012 Nov;33(33):8540-7

Jones CF, Campbell RA, Brooks AE, Assemi S, Tadjiki S, Thiagarajan G, Mulcock C, Weyrich AS, Brooks BD, Ghandehari H, Grainger DW, Cationic PAMAM dendrimers aggressively initiate blood clot formation. ACS Nano 2012 Nov 27;6(11):9900-10

Holt DJ, Grainger DW, Senescence and quiescence induced compromised function in cultured macrophages. Biomaterials 2012 Oct;33(30):7497-507

Holt DJ, Grainger DW, Demineralized bone matrix as a vehicle for delivering endogenous and exogenous therapeutics in bone repair. Adv Drug Deliv Rev 2012 Sep;64(12):1123-8

Wang Y, Grainger DW, RNA therapeutics targeting osteoclast-mediated excessive bone resorption. Adv Drug Deliv Rev 2012 Sep;64(12):1341-57

Sanders WG, Hogrebe PC, Grainger DW, Cheung AK, Terry CM, A biodegradable perivascular wrap for controlled, local and directed drug delivery. J Control Release 2012 Jul 10;161(1):81-9

Jones CF, Campbell RA, Franks Z, Gibson CC, Thiagarajan G, Vieira-de-Abreu A, Sukavaneshvar S, Mohammad SF, Li DY, Ghandehari H, Weyrich AS, Brooks BD, Grainger DW, Cationic PAMAM dendrimers disrupt key platelet functions. Mol Pharm 2012 Jun 4;9(6):1599-611

Astashkina AI, Mann BK, Prestwich GD, Grainger DW, Comparing predictive drug nephrotoxicity biomarkers in kidney 3-D primary organoid culture and immortalized cell lines. Biomaterials 2012 Jun;33(18):4712-21

Astashkina AI, Mann BK, Prestwich GD, Grainger DW, A 3-D organoid kidney culture model engineered for high-throughput nephrotoxicity assays. Biomaterials 2012 Jun;33(18):4700-11

Astashkina A, Mann B, Grainger DW, A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity. Pharmacol Ther 2012 Apr;134(1):82-106

Wang Y, Panasiuk A, Grainger DW, Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures. Mol Pharm 2011 Aug 1;8(4):1016-24

Holt DJ, Grainger DW, Multinucleated giant cells from fibroblast cultures. Biomaterials 2011 Jun;32(16):3977-87

Davidoff SN, Sevy JO, Brooks BD, Grainger DW, Brooks AE, Evaluating antibiotic release profiles as a function of polymer coating formulation - biomed 2011. Biomed Sci Instrum 2011;47:46-51

Holt DJ, Chamberlain LM, Grainger DW, Cell-cell signaling in co-cultures of macrophages and fibroblasts. Biomaterials 2010 Dec;31(36):9382-94

Takahashi H, Wang Y, Grainger DW, Device-based local delivery of siRNA against mammalian target of rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation. J Control Release 2010 Nov 1;147(3):400-7

Wang Y, Grainger DW, siRNA knock-down of RANK signaling to control osteoclast-mediated bone resorption. Pharm Res 2010 Jul;27(7):1273-84

Liu F, Dubey M, Takahashi H, Castner DG, Grainger DW, Immobilized antibody orientation analysis using secondary ion mass spectrometry and fluorescence imaging of affinity-generated patterns. Anal Chem 2010 Apr 1;82(7):2947-58

Saldarriaga Fernández IC, Mei HC, Metzger S, Grainger DW, Engelsman AF, Nejadnik MR, Busscher HJ, In vitro and in vivo comparisons of staphylococcal biofilm formation on a cross-linked poly(ethylene glycol)-based polymer coating. Acta Biomater 2010 Mar;6(3):1119-24

Davidoff SN, Call BP, Hogrebe PC, Grainger DW, Brooks AE, A robust method to coat allograft bone with a drug-releasing polymer shell - biomed 2010. Biomed Sci Instrum 2010;46:184-9

Sevy JO, Slawson MH, Grainger DW, Brooks AE, Assay method for polymer-controlled antibiotic release from allograft bone to target orthopaedic infections - biomed 2010. Biomed Sci Instrum 2010;46:136-41

Grainger DW, Castner DG, Dubey M, Emoto K, Takahashi H, Affinity-based Protein Surface Pattern Formation by Ligand Self-Selection from Mixed Protein Solutions. Adv Funct Mater 2009 Oct 9;19(19):3046-3055

Grainger DW, DNA nanotechnology: Geometric sorting boards. Nat Nanotechnol 2009 Sep;4(9):543-4

Higgins DM, Basaraba RJ, Hohnbaum AC, Lee EJ, Grainger DW, Gonzalez-Juarrero M, Localized immunosuppressive environment in the foreign body response to implanted biomaterials. Am J Pathol 2009 Jul;175(1):161-70

Grainger DW, Nanotoxicity assessment: all small talk? Adv Drug Deliv Rev 2009 Jun 21;61(6):419-21

Jones CF, Grainger DW, In vitro assessments of nanomaterial toxicity. Adv Drug Deliv Rev 2009 Jun 21;61(6):438-56

Chamberlain LM, Godek ML, Gonzalez-Juarrero M, Grainger DW, Phenotypic non-equivalence of murine (monocyte-) macrophage cells in biomaterial and inflammatory models. J Biomed Mater Res A 2009 Mar 15;88(4):858-71

Dubey M, Emoto K, Cheng F, Gamble LJ, Takahashi H, Grainger DW, Castner DG, Surface Analysis of Photolithographic Patterns using ToF-SIMS and PCA. Surf Interface Anal 2009 Mar 18;41(8):645-652

Takahashi H, Emoto K, Dubey M, Castner DG, Grainger DW, Imaging surface immobilization chemistry: correlation with cell patterning on non-adhesive hydrogel thin films. Adv Funct Mater 2008 Jul;18(14):2079-2088

Ayres N, Holt DJ, Jones CF, Corum LE, Grainger DW, Polymer Brushes Containing Sulfonated Sugar Repeat Units: Synthesis, Characterization and In Vitro Testing of Blood Coagulation Activation. J Polym Sci A Polym Chem 2008;46(23):7713-7724

Grainger DW, Peer review as professional responsibility: a quality control system only as good as the participants. Biomaterials 2007 Dec;28(34):5199-203

Takahashi H, Letourneur D, Grainger DW, Delivery of large biopharmaceuticals from cardiovascular stents: a review. Biomacromolecules 2007 Nov;8(11):3281-93

Cheng F, Gamble LJ, Grainger DW, Castner DG, X-ray Photoelectron Spectroscopy, Time-of-Flight Secondary Ion Mass Spectrometry, and Principal Component Analysis of the Hydrolysis, Regeneration, and Reactivity of N-Hydroxysuccinimide-Containing Organic Thin Films. Anal Chem 2007 Nov 15;79(22):8781-8788

Saldarriaga Fernandez IC, van der Mei HC, Lochhead MJ, Grainger DW, Busscher H , The inhibition of the adhesion of clinically isolated bacterial strains on multi-component cross-linked poly(ethylene glycol)-based polymer coatings. Biomaterials 2007 Oct;28(28):4105-12

Lee CY, Harbers GM, Grainger DW, Gamble LJ, Castner D , Fluorescence, XPS, and TOF-SIMS Surface Chemical State Image Analysis of DNA Microarrays. J Am Chem Soc 2007 Jul 11;:

Kuijer R, Jansen EJ, Emans PJ, Bulstra SK, Riesle J, Pieper J, Grainger DW, Busscher H , Assessing infection risk in implanted tissue-engineered devices. Biomaterials 2007 Jun 25;:

Lee CY, Nguyen PC, Grainger DW, Gamble LJ, Castner D , Structure and DNA Hybridization Properties of Mixed Nucleic Acid/Maleimide-Ethylene Glycol Monolayers. Anal Chem 2007 Jun 15;79(12):4390-4400

Dandy DS, Wu P, Grainger D , Array feature size influences nucleic acid surface capture in DNA microarrays. Proc Natl Acad Sci U S A 2007 May 15;104(20):8223-8

Grainger DW, Greef CH, Gong P, Lochhead MJ, Current microarray surface chemistries. Methods Mol Biol 2007;381:37-57

Godek ML, Malkov GS, Fisher ER, Grainger D , Macrophage Serum-Based Adhesion to Plasma-Processed Surface Chemistry is Distinct from That Exhibited by Fibroblasts. Plasma Process Polym 2006 Aug 15;3(6-7):485-497

Lee CY, Gong P, Harbers GM, Grainger DW, Castner DG, Gamble L , Surface coverage and structure of mixed DNA/Alkylthiol monolayers on gold: characterization by XPS, NEXAFS, and fluorescence intensity measurements. Anal Chem 2006 May 15;78(10):3316-25

Gong P, Harbers GM, Grainger D , Multi-technique comparison of immobilized and hybridized oligonucleotide surface density on commercial amine-reactive microarray slides. Anal Chem 2006 Apr 1;78(7):2342-51

Wu P, Grainger D , Drug/device combinations for local drug therapies and infection prophylaxis. Biomaterials 2006 Apr;27(11):2450-67

Christie RJ, Findley DJ, Dunfee M, Hansen RD, Olsen SC, Grainger D , Photopolymerized hydrogel carriers for live vaccine ballistic delivery. Vaccine 2006 Feb 27;24(9):1462-9

Wu P, Hogrebe P, Grainger D , DNA and protein microarray printing on silicon nitride waveguide surfaces. Biosens Bioelectron 2006 Jan 15;21(7):1252-63

Grainger D , Controlled-release and local delivery of therapeutic antibodies. Expert Opin Biol Ther 2004 Jul;4(7):1029-44