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James N. Herron

Phone: 801-581-7303
Office: 108B BPR

James N. Herron

Associate Professor of Pharmaceutics
Adjunct Associate Professor, Bioengineering
Ph.D., Microbiology
University of Illinois Urbana-Champaign

Selected Publications

Kaur I, Kosak KM, Terrazas M, Herron JN, Kern SE, Boucher KM, Shami PJ, Effect of a Pluronic() P123 formulation on the nitric oxide-generating drug JS-K. Pharm Res 2015 Apr;32(4):1395-406

Duer R, Lund R, Tanaka R, Christensen DA, Herron JN, In-plane parallel scanning: a microarray technology for point-of-care testing. Anal Chem 2010 Nov 1;82(21):8856-65

Christensen DA, Herron JN, Optical system design for biosensors based on CCD detection. Methods Mol Biol 2009;503:239-58

Guo J, Elzinga PA, Hageman MJ, Herron JN, Rapid throughput screening of apparent KSP values for weakly basic drugs using 96-well format. J Pharm Sci 2008 Jun;97(6):2080-90

Guo J, Elzinga PA, Hageman MJ, Herron JN, Rapid throughput solubility screening method for BCS class II drugs in animal GI fluids and simulated human GI fluids using a 96-well format. J Pharm Sci 2008 Apr;97(4):1427-42

Cavenaugh JS, Wang HK, Sha J, Hansen C, Papangkorn K, Smith RS, Herron JN, How well can an idiotope peptide mimic replace its parent idiotype in a synthetic peptide vaccine? Pharm Res 2004 Aug;21(8):1480-8

Tolley SE, Wang HK, Smith RS, Christensen DA, Herron JN, Single-chain polymorphism analysis in long QT syndrome using planar waveguide fluorescent biosensors. Anal Biochem 2003 Apr 15;315(2):223-37

Cavenaugh JS, Wang HK, Hansen C, Smith RS, Herron JN, How well can a T-cell epitope replace its parent carrier protein? A dose-response study. Pharm Res 2003 Apr;20(4):591-6

Wei AP, Herron JN, Bifluorophoric molecules as fluorescent beacons for antibody-antigen binding. J Mol Recognit 2002 Sep-Oct;15(5):311-20

Liu XH, Wang HK, Herron JN, Prestwich GD, Photopatterning of antibodies on biosensors. Bioconjug Chem 2000 Nov-Dec;11(6):755-61

Rapoport NY, Herron JN, Pitt WG, Pitina L, Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60 cells: effect of micelle structure and ultrasound on the intracellular drug uptake. J Control Release 1999 Mar 29;58(2):153-62

Yoneto K, Li SK, Higuchi WI, Jiskoot W, Herron JN, Fluorescent probe studies of the interactions of 1-alkyl-2-pyrrolidones with stratum corneum lipid liposomes. J Pharm Sci 1996 May;85(5):511-7

Lim K, Herron JN, Molecular dynamics of the anti-fluorescein 4-4-20 antigen-binding fragment. 1. Computer simulations. Biochemistry 1995 May 30;34(21):6962-74

Lim K, Jameson DM, Gentry CA, Herron JN, Molecular dynamics of the anti-fluorescein 4-4-20 antigen-binding fragment. 2. Time-resolved fluorescence spectroscopy. Biochemistry 1995 May 30;34(21):6975-84

Chang IN, Lin JN, Andrade JD, Herron JN, Photoaffinity labeling of antibodies for applications in homogeneous fluoroimmunoassays. Anal Chem 1995 Mar 1;67(5):959-66

Jiskoot W, Hlady V, Naleway JJ, Herron JN, Application of fluorescence spectroscopy for determining the structure and function of proteins. Pharm Biotechnol 1995;7:1-63

Herron JN, Terry AH, Johnston S, He XM, Guddat LW, Voss EW Jr, Edmundson AB, High resolution structures of the 4-4-20 Fab-fluorescein complex in two solvent systems: effects of solvent on structure and antigen-binding affinity. Biophys J 1994 Dec;67(6):2167-83

Wei AP, Blumenthal DK, Herron JN, Antibody-mediated fluorescence enhancement based on shifting the intramolecular dimer<-->monomer equilibrium of fluorescent dyes. Anal Chem 1994 May 1;66(9):1500-6

Wei AP, Herron JN, Use of synthetic peptides as tracer antigens in fluorescence polarization immunoassays of high molecular weight analytes. Anal Chem 1993 Dec 1;65(23):3372-7

Omelyanenko VG, Jiskoot W, Herron JN, Role of electrostatic interactions in the binding of fluorescein by anti-fluorescein antibody 4-4-20. Biochemistry 1993 Oct 5;32(39):10423-9

Kim YH, Higuchi WI, Herron JN, Abraham W, Fluorescence anisotropy studies on the interaction of the short chain n-alkanols with stratum corneum lipid liposomes (SCLL) and distearoylphosphatidylcholine (DSPC)/distearoylphosphatidic acid (DSPA) liposomes. Biochim Biophys Acta 1993 May 14;1148(1):139-51

Lea AS, Pungor A, Hlady V, Andrade JD, Herron JN, Voss EW Jr, Manipulation of Proteins on Mica by Atomic Force Microscopy. Langmuir 1992;8(1):68-73

Herron JN, He XM, Ballard DW, Blier PR, Pace PE, Bothwell AL, Voss EW Jr, Edmundson AB, An autoantibody to single-stranded DNA: comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex. Proteins 1991;11(3):159-75

Ely KR, Herron JN, Edmundson AB, Three-dimensional structure of a hybrid light chain dimer: protein engineering of a binding cavity. Mol Immunol 1990 Feb;27(2):101-14

Ely KR, Herron JN, Harker M, Edmundson AB, Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms. J Mol Biol 1989 Dec 5;210(3):601-15

Edmundson AB, Herron JN, Ely KR, He XM, Harris DL, Voss EW Jr, Synthetic site-directed ligands. Philos Trans R Soc Lond B Biol Sci 1989 Jun 12;323(1217):495-509

Edmundson AB, Ely KR, He XM, Herron JN, Cocrystallization of an immunoglobulin light chain dimer with bis(dinitrophenyl) lysine: tandem binding of two ligands, one with and one without accompanying conformational changes in the protein. Mol Immunol 1989 Mar;26(3):207-20

Herron JN, He XM, Mason ML, Voss EW Jr, Edmundson AB, Three-dimensional structure of a fluorescein-Fab complex crystallized in 2-methyl-2,4-pentanediol. Proteins 1989;5(4):271-80

Gibson AL, Herron JN, He XM, Patrick VA, Mason ML, Lin JN, Kranz DM, Voss EW Jr, Edmundson AB, Differences in crystal properties and ligand affinities of an antifluorescyl Fab (4-4-20) in two solvent systems. Proteins 1988;3(3):155-60

Edmundson AB, Ely KR, Herron JN, Cheson BD, The binding of opioid peptides to the Mcg light chain dimer: flexible keys and adjustable locks. Mol Immunol 1987 Sep;24(9):915-35