Research

Current Research

Selected Publications

Frøkjaer-Jensen C, Jorgensen EM, Calcium: an insignificant thing. Nat Neurosci 2009 Oct;12(10):1213-4

Liu Q, Hollopeter G, Jorgensen EM, Graded synaptic transmission at the Caenorhabditis elegans neuromuscular junction. Proc Natl Acad Sci U S A 2009 Jun 30;106(26):10823-8

Hammarlund M, Nix P, Hauth L, Jorgensen EM, Bastiani M, Axon regeneration requires a conserved MAP kinase pathway. Science 2009 Feb 6;323(5915):802-6

Gu M, Schuske K, Watanabe S, Liu Q, Baum P, Garriga G, Jorgensen EM, Mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans. J Cell Biol 2008 Dec 1;183(5):881-92

Frøkjaer-Jensen C, Davis MW, Hopkins CE, Newman BJ, Thummel JM, Olesen SP, Grunnet M, Jorgensen EM, Single-copy insertion of transgenes in Caenorhabditis elegans. Nat Genet 2008 Nov;40(11):1375-83

Davis MW, Morton JJ, Carroll D, Jorgensen EM, Gene activation using FLP recombinase in C. elegans. PLoS Genet 2008 Mar 21;4(3):e1000028

Hammarlund M, Watanabe S, Schuske K, Jorgensen EM, CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons. J Cell Biol 2008 Feb 11;180(3):483-91

Beg AA, Ernstrom GG, Nix P, Davis MW, Jorgensen EM, Protons act as a transmitter for muscle contraction in C. elegans. Cell 2008 Jan 11;132(1):149-60

White JQ, Nicholas TJ, Gritton J, Truong L, Davidson ER, Jorgensen EM, The sensory circuitry for sexual attraction in C. elegans males. Curr Biol 2007 Nov 6;17(21):1847-57

Peters MA, Teramoto T, White JQ, Iwasaki K, Jorgensen EM, A Calcium Wave Mediated by Gap Junctions Coordinates a Rhythmic Behavior in C. elegans. Curr Biol 2007 Sep 18;17(18):1601-8

Jospin M, Watanabe S, Joshi D, Young S, Hamming K, Thacker C, Snutch TP, Jorgensen EM, Schuske K, UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants. Curr Biol 2007 Sep 18;17(18):1595-600

Hammarlund M, Palfreyman MT, Watanabe S, Olsen S, Jorgensen EM, Open syntaxin docks synaptic vesicles. PLoS Biol 2007 Aug;5(8):e198

Schuske K, Palfreyman MT, Watanabe S, Jorgensen EM, UNC-46 is required for trafficking of the vesicular GABA transporter. Nat Neurosci 2007 Jul;10(7):846-53

Speese S, Petrie M, Schuske K, Ailion M, Ann K, Iwasaki K, Jorgensen EM, Martin TF, UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans. J Neurosci 2007 Jun 6;27(23):6150-62

Bednarek EM, Schaheen L, Gaubatz J, Jorgensen EM, Fares H, The plasma membrane calcium ATPase MCA-3 is required for clathrin-mediated endocytosis in scavenger cells of Caenorhabditis elegans. Traffic 2007 May;8(5):543-53

Palfreyman M, Jorgensen EM, PKC defends crown against Munc13. Neuron 2007 Apr 19;54(2):179-80

Hammarlund M, Jorgensen EM, Bastiani MJ, Axons break in animals lacking beta-spectrin. J Cell Biol 2007 Jan 29;176(3):269-75

Morton J, Davis MW, Jorgensen EM, Carroll D, Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells. Proc Natl Acad Sci U S A 2006 Oct 31;103(44):16370-5

Wardell B, Marik PS, Piper D, Rutar T, Jorgensen EM, Bamber BA, Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate. Br J Pharmacol 2006 May;148(2):162-72

Hammarlund M, Davis MW, Nguyen H, Dayton D, Jorgensen EM, Heterozygous insertions alter crossover distribution but allow crossover interference in Caenorhabditis elegans. Genetics 2005 Nov;171(3):1047-56

Williams DC, Boulin T, Ruaud AF, Jorgensen EM, Bessereau JL, Characterization of Mos1-mediated mutagenesis in Caenorhabditis elegans: a method for the rapid identification of mutated genes. Genetics 2005 Mar;169(3):1779-85

Bamber BA, Richmond JE, Otto JF, Jorgensen EM, The composition of the GABA receptor at the Caenorhabditis elegans neuromuscular junction. Br J Pharmacol 2005 Feb;144(4):502-9

Davis MW, Hammarlund M, Harrach T, Hullett P, Olsen S, Jorgensen EM, Rapid single nucleotide polymorphism mapping in C. elegans. BMC Genomics 2005 Sep 12;6():118

Jorgensen EM, GABA. WormBook 2005 Aug 31;():1-13

Davis MW, Birnie AJ, Chan AC, Page AP, Jorgensen EM, A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans. Development 2004 Dec;131(23):6001-8

Schuske K, Beg AA, Jorgensen EM, The GABA nervous system in C. elegans. Trends Neurosci 2004 Jul;27(7):407-14

Schuske K, Jorgensen EM, Neuroscience. Vesicular glutamate transporter--shooting blanks. Science 2004 Jun 18;304(5678):1750-2

Schuske KR, Richmond JE, Matthies DS, Davis WS, Runz S, Rube DA, van der Bliek AM, Jorgensen EM, Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin. Neuron 2003 Nov 13;40(4):749-62

Beg AA, Jorgensen EM, EXP-1 is an excitatory GABA-gated cation channel. Nat Neurosci 2003 Nov;6(11):1145-52

Weimer RM, Richmond JE, Davis WS, Hadwiger G, Nonet ML, Jorgensen EM, Defects in synaptic vesicle docking in unc-18 mutants. Nat Neurosci 2003 Oct;6(10):1023-30

Weimer RM, Jorgensen EM, Controversies in synaptic vesicle exocytosis. J Cell Sci 2003 Sep 15;116(Pt 18):3661-6

Bamber BA, Twyman RE, Jorgensen EM, Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans. Br J Pharmacol 2003 Mar;138(5):883-93

Jorgensen EM, Mango SE, The art and design of genetic screens: caenorhabditis elegans. Nat Rev Genet 2002 May;3(5):356-69

Knobel KM, Davis WS, Jorgensen EM, Bastiani MJ, UNC-119 suppresses axon branching in C. elegans. Development 2001 Oct;128(20):4079-92

Harris TW, Schuske K, Jorgensen EM, Studies of synaptic vesicle endocytosis in the nematode C. elegans. Traffic 2001 Sep;2(9):597-605

Bessereau JL, Wright A, Williams DC, Schuske K, Davis MW, Jorgensen EM, Mobilization of a Drosophila transposon in the Caenorhabditis elegans germ line. Nature 2001 Sep 6;413(6851):70-4

Richmond JE, Weimer RM, Jorgensen EM, An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming. Nature 2001 Jul 19;412(6844):338-41

Yook KJ, Proulx SR, Jorgensen EM, Rules of nonallelic noncomplementation at the synapse in Caenorhabditis elegans. Genetics 2001 May;158(1):209-20

Harris TW, Hartwieg E, Horvitz HR, Jorgensen EM, Mutations in synaptojanin disrupt synaptic vesicle recycling. J Cell Biol 2000 Aug 7;150(3):589-600

Hammarlund M, Davis WS, Jorgensen EM, Mutations in beta-spectrin disrupt axon outgrowth and sarcomere structure. J Cell Biol 2000 May 15;149(4):931-42

Richmond JE, Davis WS, Jorgensen EM, UNC-13 is required for synaptic vesicle fusion in C. elegans. Nat Neurosci 1999 Nov;2(11):959-64

Knobel KM, Jorgensen EM, Bastiani MJ, Growth cones stall and collapse during axon outgrowth in Caenorhabditis elegans. Development 1999 Oct;126(20):4489-98

Dal Santo P, Logan MA, Chisholm AD, Jorgensen EM, The inositol trisphosphate receptor regulates a 50-second behavioral rhythm in C. elegans. Cell 1999 Sep 17;98(6):757-67

Richmond JE, Jorgensen EM, One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction. Nat Neurosci 1999 Sep;2(9):791-7

Bamber BA, Beg AA, Twyman RE, Jorgensen EM, The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor. J Neurosci 1999 Jul 1;19(13):5348-59

Jorgensen EM, Hartwieg E, Schuske K, Nonet ML, Jin Y, Horvitz HR, Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans. Nature 1995 Nov 9;378(6553):196-9

Wittwer CT, Graves CP, Peterson MA, Jorgensen E, Wilson DE, Thoene JG, Wyse BW, Windham CT, Hansen RG, Pantethine lipomodulation: evidence for cysteamine mediation in vitro and in vivo. Atherosclerosis 1987 Nov;68(1-2):41-9