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James P. (Pat) McAllister

Phone: 801-585-5501
Office: Clinical Neuroscience Center Rm. 3230D

James P. (Pat) McAllister

Professor of Neurosurgery
Director of Basic Hydrocephalus Research
Adjunct Professor, Bioengineering
PhD, Neurobiology, Purdue University, W. Lafayette, IN
BS, Biology, Earlham College, Richmond, IN


Pathophysiology of hydrocephalus and brain injury; neural prostheses and implantable intracranial devices; biocompatibility

Current Research

Our lab maintains a comprehensive interdisciplinary research program whose ultimate goal is to improve clinical treatments for hydrocephalus, a prevalent form of traumatic brain injury caused by failure to absorb cerebrospinal fluid. This program continues to explore the cellular and physiological neuropathology associated with neonatal, infantile and adult hydrocephalus and focuses on neuroinflammation, non-invasive neuroimaging (MRI and diffusion tensor imaging), pharmacological strategies for neuroprotection and recovery of function, and clinical evaluations of patient outcome and new treatment applications. Our multidisciplinary approach also includes biomedical engineering improvements in the design of cerebrospinal fluid drainage systems (shunts), development of implantable sensors, and the biocompatibility of neural prostheses. Our lab creates an interface between basic research and clinical applications, and thus trains graduate students as well as neurosurgery residents. We maintain active collaborations with investigators at the Albert Einstein College of Medicine, the University of Birmingham in the United Kingdom, the Universidad Austral de Chile in Valdivia Chile, the University of Washington and Seattle Children's Hospital, Copenhagen University Hospital in Denmark, and Boston Children's Hospital and Harvard University.

Selected Publications

Adam A, Robison J, Lu J, Jose R, Badran N, Vivas-Buitrago T, Rigamonti D, Sattar A, Omoush O, Hammad M, Dawood M, Maghaslah M, Belcher T, Carson K, Hoffberger J, Jusué Torres I, Foley S, Yasar S, Thai QA, Wemmer J, Klinge P, Al-Mutawa L, Al-Ghamdi H, Cars, Abstracts from Hydrocephalus 2016. Fluids Barriers CNS 2017 Jun 7;14(Suppl 1):15

Aojula A, Botfield H, McAllister JP 2nd, Gonzalez AM, Abdullah O, Logan A, Sinclair A, Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus. Fluids Barriers CNS 2016 May 31;13(1):9

McAllister JP 2nd, Williams MA, Walker ML, Kestle JR, Relkin NR, Anderson AM, Gross PH, Browd SR, An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium "Opportunities for Hydrocephalus Research: Pathways to Better Outcomes". J Neurosurg 2015 Dec;123(6):1427-38

Guerra MM, Henzi R, Ortloff A, Lichtin N, Vío K, Jiménez AJ, Dominguez-Pinos MD, González C, Jara MC, Hinostroza F, Rodríguez S, Jara M, Ortega E, Guerra F, Sival DA, den Dunnen WF, Pérez-Fígares JM, McAllister JP, Johanson CE, Rodríguez EM, Cell Junction Pathology of Neural Stem Cells Is Associated With Ventricular Zone Disruption, Hydrocephalus, and Abnormal Neurogenesis. J Neuropathol Exp Neurol 2015 Jul;74(7):653-71

Morales DM, Holubkov R, Inder TE, Ahn HC, Mercer D, Rao R, McAllister JP 2nd, Holtzman DM, Limbrick DD Jr, Cerebrospinal fluid levels of amyloid precursor protein are associated with ventricular size in post-hemorrhagic hydrocephalus of prematurity. PLoS One 2015;10(3):e0115045

Williams MT, Braun AA, Amos-Kroohs RM, McAllister JP 2nd, Lindquist DM, Mangano FT, Vorhees CV, Yuan W, Kaolin-induced ventriculomegaly at weaning produces long-term learning, memory, and motor deficits in rats. Int J Dev Neurosci 2014 Jun;35:7-15

Simon TD, Van Yserloo B, Nelson K, Gillespie D, Jensen R, McAllister JP 2nd, Riva-Cambrin J, Stockmann C, Daly JA, Blaschke AJ, Use of quantitative 16S rRNA PCR to determine bacterial load does not augment conventional cerebrospinal fluid (CSF) cultures among children undergoing treatment for CSF shunt infection. Diagn Microbiol Infect Dis 2014 Feb;78(2):188-95

Botfield H, Gonzalez AM, Abdullah O, Skjolding AD, Berry M, McAllister JP 2nd, Logan A, Decorin prevents the development of juvenile communicating hydrocephalus. Brain 2013 Sep;136(Pt 9):2842-58

Eskandari R, Packer M, Burdett EC, McAllister JP 2nd, Effect of delayed intermittent ventricular drainage on ventriculomegaly and neurological deficits in experimental neonatal hydrocephalus. Childs Nerv Syst 2012 Nov;28(11):1849-61

McAllister JP 2nd, Pathophysiology of congenital and neonatal hydrocephalus. Semin Fetal Neonatal Med 2012 Oct;17(5):285-94

Harris CA, McAllister JP 2nd, What we should know about the cellular and tissue response causing catheter obstruction in the treatment of hydrocephalus. Neurosurgery 2012 Jun;70(6):1589-601; discussion 1601-2

Eskandari R, Harris CA, McAllister JP 2nd, Reactive astrocytosis in feline neonatal hydrocephalus: acute, chronic, and shunt-induced changes. Childs Nerv Syst 2011 Dec;27(12):2067-76

McAllister JP, Getting to the root of hydrocephalus. Sci Transl Med 2011 Sep 7;3(99):99fs4

Harris CA, Resau JH, Hudson EA, West RA, Moon C, Black AD, McAllister JP 2nd, Reduction of protein adsorption and macrophage and astrocyte adhesion on ventricular catheters by polyethylene glycol and N-acetyl-L-cysteine. J Biomed Mater Res A 2011 Sep 1;98(3):425-33

Rashid S, McAllister JP 2nd, Yu Y, Wagshul ME, Neocortical capillary flow pulsatility is not elevated in experimental communicating hydrocephalus. J Cereb Blood Flow Metab 2011 Sep 21;:

Harris CA, McAllister JP 2nd, Does drainage hole size influence adhesion on ventricular catheters? Childs Nerv Syst 2011 Aug;27(8):1221-32

Harris CA, Resau JH, Hudson EA, West RA, Moon C, Black AD, McAllister JP 2nd, Effects of surface wettability, flow, and protein concentration on macrophage and astrocyte adhesion in an in vitro model of central nervous system catheter obstruction. J Biomed Mater Res A 2011 Jun 15;97(4):433-40

Deren KE, Packer M, Forsyth J, Milash B, Abdullah OM, Hsu EW, McAllister JP 2nd, Reactive astrocytosis, microgliosis and inflammation in rats with neonatal hydrocephalus. Exp Neurol 2010 Nov;226(1):110-9

Harris CA, Resau JH, Hudson EA, West RA, Moon C, McAllister JP 2nd, Mechanical contributions to astrocyte adhesion using a novel in vitro model of catheter obstruction. Exp Neurol 2010 Apr;222(2):204-10

McAllister JP 2nd, Miller JM, Minocycline inhibits glial proliferation in the H-Tx rat model of congenital hydrocephalus. Cerebrospinal Fluid Res 2010 May 27;7:7

Nagra G, Wagshul ME, Rashid S, Li J, McAllister JP 2nd, Johnston M, Elevated CSF outflow resistance associated with impaired lymphatic CSF absorption in a rat model of kaolin-induced communicating hydrocephalus. Cerebrospinal Fluid Res 2010 Feb 10;7(1):4

Krishnamurthy S, Li J, Schultz L, McAllister JP 2nd, Intraventricular infusion of hyperosmolar dextran induces hydrocephalus: a novel animal model of hydrocephalus. Cerebrospinal Fluid Res 2009 Dec 11;6(1):16

Wagshul ME, McAllister JP, Rashid S, Li J, Egnor MR, Walker ML, Yu M, Smith SD, Zhang G, Chen JJ, Benveniste H, Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus. Exp Neurol 2009 Jul;218(1):33-40

Deren KE, Forsyth J, Abdullah O, Hsu EW, Klinge PM, Silverberg GD, Johanson CE, McAllister JP 2nd, Low levels of amyloid-beta and its transporters in neonatal rats with and without hydrocephalus. Cerebrospinal Fluid Res 2009 May 26;6:4

McAllister JP, Wagshul ME, Rashid S, Li J, Measurement of capillary pulsations in the rat neocortex with two-photon laser scanning confocal microscopy. Cerebrospinal Fluid Res 2009 Nov 27;6 Suppl 2:S10

McAllister JP, Deren KE, Shereen A, Yuan W, Lindquist DM, Holland SK, Mangano FT, Brain damage in experimental neonatal hydrocephalus: correlations between diffusion tensor imaging and cytopathology. Cerebrospinal Fluid Res 2009 Nov 27;6 Suppl 2:S11

McAllister JP 2nd, Forsyth J, Deren KE, Global neuroinflammation patterns in experimental neonatal hydrocephalus. Cerebrospinal Fluid Res 2009 Nov 27;6 Suppl 2:S12

Nagra G, Li J, McAllister JP 2nd, Miller J, Wagshul M, Johnston M, Impaired lymphatic cerebrospinal fluid absorption in a rat model of kaolin-induced communicating hydrocephalus. Am J Physiol Regul Integr Comp Physiol 2008 May;294(5):R1752-R1759

Williams MA, McAllister JP, Walker ML, Kranz DA, Bergsneider M, Del Bigio MR, Fleming L, Frim DM, Gwinn K, Kestle JR, Luciano MG, Madsen JR, Oster-Granite ML, Spinella G, Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshop. J Neurosurg 2007 Nov;107(5):345-357

Wang A, Liang X, McAllister JP 2nd, Li J, Brabant K, Black C, Finlayson P, Cao T, Tang H, Salley SO, Auner GW, Simon Ng K , Stability of and inflammatory response to silicon coated with a fluoroalkyl self-assembled monolayer in the central nervous system. J Biomed Mater Res A 2007 May;81(2):363-72

Parthasarathy KS, Cheng YC, McAllister JP 2nd, Shen Y, Li J, Deren K, Haacke EM, Auner G , Biocompatibilities of sapphire and borosilicate glass as cortical neuroprostheses. Magn Reson Imaging 2007 Apr 24;:

Tang H, Cao T, Wang A, Liang X, Salley SO, McAllister JP 2nd, Ng K , Effect of surface modification of siliconeon Staphylococcus epidermidis adhesion and colonization. J Biomed Mater Res A 2007 Mar 15;80(4):885-94

Miller JM, McAllister JP 2n , Reduction of astrogliosis and microgliosis by cerebrospinal fluid shunting in experimental hydrocephalus. Cerebrospinal Fluid Res 2007 Jun 7;4:5

Liang X, Wang A, Tang H, Cao T, McAllister JP 2nd, Salley SO, Ng K , The effect of self-assembled layers on the release behavior of rifampicin-loaded silicone. J Biomater Sci Polym Ed 2007;18(6):687-700

McAllister JP 2nd, Abdolvahabi RM, Walker ML, Mitchell JA, Jones H , Effects of congenital hydrocephalus on the hypothalamic gonadotrophin-releasing hormone system. Neurosurg Focus 2007 Apr 15;22(4):E4

McAllister JP 2nd, Miller J , Aquaporin 4 and hydrocephalus. J Neurosurg 2006 Dec;105(6 Suppl):457-8; discussion 458

Tang H, Wang A, Liang X, Cao T, Salley SO, McAllister JP 3rd, Ng K , Effect of surface proteins on Staphylococcus epidermidis adhesion and colonization on silicone. Colloids Surf B Biointerfaces 2006 Aug 1;51(1):16-24

McAllister JP 2n , Neuronal damage in hydrocephalus. J Neurosurg 2006 May;104(5 Suppl):297-8; discussion 298

Liang X, Wang A, Cao T, Tang H, McAllister JP 2nd, Salley SO, Ng K , Effect of cast molded rifampicin/silicone on Staphylococcus epidermidis biofilm formation. J Biomed Mater Res A 2006 Mar 1;76(3):580-8

Patel KR, Tang H, Grever WE, Simon Ng KY, Xiang J, Keep RF, Cao T, McAllister JP 2n , Evaluation of polymer and self-assembled monolayer-coated silicone surfaces to reduce neural cell growth. Biomaterials 2006 Mar;27(8):1519-26

Bergsneider M, Egnor MR, Johnston M, Kranz D, Madsen JR, McAllister JP 2nd, Stewart C, Walker ML, Williams M , What we don't (but should) know about hydrocephalus. J Neurosurg 2006 Mar;104(3 Suppl):157-9

Miller JM, Kumar R, McAllister JP 2nd, Krause G , Gene expression analysis of the development of congenital hydrocephalus in the H-Tx rat. Brain Res 2006 Feb 23;1075(1):36-47

Wang A, Cao T, Tang H, Liang X, Black C, Salley SO, McAllister JP, Auner GW, Ng K , Immobilization of polysaccharides on a fluorinated silicon surface. Colloids Surf B Biointerfaces 2006 Jan 15;47(1):57-63

Li J, Ding YH, Rafols JA, Lai Q, McAllister JP 2nd, Ding , Increased astrocyte proliferation in rats after running exercise. Neurosci Lett 2005 Oct 7;386(3):160-4

Schuhmann MU, Ostrowski KR, Draper EJ, Chu JW, Ham SD, Sood S, McAllister J , The value of C-reactive protein in the management of shunt infections. J Neurosurg 2005 Sep;103(3 Suppl):223-30

Ding YH, Young CN, Luan X, Li J, Rafols JA, Clark JC, McAllister JP 2nd, Ding , Exercise preconditioning ameliorates inflammatory injury in ischemic rats during reperfusion. Acta Neuropathol (Berl) 2005 Mar;109(3):237-46

Eskandari R, Mcallister JP 2nd, Miller JM, Ding Y, Ham SD, Shearer DM, Way J , Effects of hydrocephalus and ventriculoperitoneal shunt therapy on afferent and efferent connections in the feline sensorimotor cortex. J Neurosurg 2004 Nov;101(2 Suppl):196-210

Li J, Luan X, Lai Q, Clark JC, McAllister JP 2nd, Fessler R, Diaz FG, Ding , Long-term neuroprotection induced by regional brain cooling with saline infusion into ischemic territory in rats: a behavioral analysis. Neurol Res 2004 Sep;26(6):677-83

Ding Y, Li J, Luan X, Lai Q, McAllister JP 2nd, Phillis JW, Clark JC, Guthikonda M, Diaz F , Local saline infusion into ischemic territory induces regional brain cooling and neuroprotection in rats with transient middle cerebral artery occlusion. Neurosurgery 2004 Apr;54(4):956-64; discussion 964-5

Luan X, Li J, McAllister JP 2nd, Diaz FG, Clark JC, Fessler RD, Ding , Regional brain cooling induced by vascular saline infusion into ischemic territory reduces brain inflammation in stroke. Acta Neuropathol (Berl) 2004 Mar;107(3):227-34

Ding Y, Young CN, Li J, Luan X, McAllister JP 2nd, Clark JD, Diaz F , Reduced inflammatory mediator expression by pre-reperfusion infusion into ischemic territory in rats: a real-time polymerase chain reaction analysis. Neurosci Lett 2003 Dec 26;353(3):173-6

Ding Y, Yao B, Zhou Y, Park H, McAllister JP 2nd, Diaz F , Prereperfusion flushing of ischemic territory: a therapeutic study in which histological and behavioral assessments were used to measure ischemia-reperfusion injury in rats with stroke. J Neurosurg 2002 Feb;96(2):310-9

Ding Y, McAllister JP 2nd, Yao B, Yan N, Canady A , Axonal damage associated with enlargement of ventricles during hydrocephalus: a silver impregnation study. Neurol Res 2001 Sep;23(6):581-7

Ding Y, Yao B, Lai Q, McAllister J , Impaired motor learning and diffuse axonal damage in motor and visual systems of the rat following traumatic brain injury. Neurol Res 2001 Mar-Apr;23(2-3):193-202

Ding Y, McAllister JP 2nd, Yao B, Yan N, Canady A , Neuron tolerance during hydrocephalus. Neuroscience 2001;106(4):659-67

Kriebel RM, McAllister JP 2n , Pathology of the hippocampus in experimental feline infantile hydrocephalus. Neurol Res 2000 Jan;22(1):29-36

McAllister JP 2n , Hydrocephalus enters the new millennium: an overview. Neurol Res 2000 Jan;22(1):2-3

Abdolvahabi RM, Mitchell JA, Diaz FG, McAllister JP 2n , A brief review of the effects of chronic hydrocephalus on the gonadotropin releasing hormone system: implications for amenorrhea and precocious puberty. Neurol Res 2000 Jan;22(1):123-6

McAllister JP 2nd, Wood AS, Johnson MJ, Connelly RW, Skarupa DJ, Secic M, Luciano MG, Harris NG, Jones H , Decreased c-fos expression in experimental neonatal hydrocephalus: evidence for reduced neuronal activation. Neurosurg Focus 1999 Oct 15;7(4):e13

Johnson MJ, Ayzman I, Wood AS, Tkach JA, Klauschie J, Skarupa DJ, McAllister JP, Luciano M , Development and characterization of an adult model of obstructive hydrocephalus. J Neurosci Methods 1999 Sep 15;91(1-2):55-65

Mangano FT, McAllister JP 2nd, Jones HC, Johnson MJ, Kriebel R , The microglial response to progressive hydrocephalus in a model of inherited aqueductal stenosis. Neurol Res 1998 Dec;20(8):697-704

McAllister JP 2nd, Mangano FT, Jones HC, Kriebel R , The microglial response in experimental infantile hydrocephalus. Eur J Pediatr Surg 1998 Dec;8 Suppl 1:62

McAllister JP 2nd, Chovan P, Steiner CP, Johnson MJ, Ayzman I, Wood AS, Tkach JA, Hahn JF, Luciano M , Differential ventricular expansion in hydrocephalus. Eur J Pediatr Surg 1998 Dec;8 Suppl 1:39-42

Bradley NK, Liakos AM, McAllister JP 2nd, Magram G, Kinsman S, Bradley M , Maternal shunt dependency: implications for obstetric care, neurosurgical management, and pregnancy outcomes and a review of selected literature. Neurosurgery 1998 Sep;43(3):448-60; discussion 460-1

McAllister JP 2nd, Chovan , Neonatal hydrocephalus. Mechanisms and consequences. Neurosurg Clin N Am 1998 Jan;9(1):73-93

Liakos AM, Bradley NK, McAllister JP, Magram G, Kinsman S , Hydrocephalus and pregnancy: the medical implications of maternal shunt dependency. Eur J Pediatr Surg 1997 Dec;7 Suppl 1:51-2

Harris NG, McAllister JP 2nd, Conaughty JM, Jones H , The effect of inherited hydrocephalus and shunt treatment on cortical pyramidal cell dendrites in the infant H-Tx rat. Exp Neurol 1996 Oct;141(2):269-79

Harris NG, McAllister JP 2nd, Jones H , The effect of untreated and shunt-treated hydrocephalus on cortical pyramidal neurone morphology in the H-Tx rat. Eur J Pediatr Surg 1993 Dec;3 Suppl 1:31-2

Kriebel RM, Shah AB, McAllister JP 2n , The microstructure of cortical neuropil before and after decompression in experimental infantile hydrocephalus. Exp Neurol 1993 Jan;119(1):89-98

Wright LC, McAllister JP 2nd, Katz SD, Miller DW, Lovely TJ, Salotto AG, Wolfson BJ, Cytological and cytoarchitectural changes in the feline cerebral cortex during experimental infantile hydrocephalus. Pediatr Neurosurg 1990-1991;16(3):139-55