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Hamid  Ghandehari

Phone: 801-587-1566
Office: 5215 SMBB

Hamid Ghandehari

Selected Publications

Anchordoquy TJ, Barenholz Y, Boraschi D, Chorny M, Decuzzi P, Dobrovolskaia MA, Farhangrazi ZS, Farrell D, Gabizon A, Ghandehari H, Godin B, La-Beck NM, Ljubimova J, Moghimi SM, Pagliaro L, Park JH, Peer D, Ruoslahti E, Serkova NJ, Simberg D, Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions. ACS Nano 2017 Jan 9;:

Zeller Meidell K, Robinson R, Vieira-de-Abreu A, Gormley AJ, Ghandehari H, W Grainger D, A Campbell R, RGDfK-functionalized gold nanorods bind only to activated platelets. J Biomed Mater Res A 2017 Jan;105(1):209-217

Saikia J, Yazdimamaghani M, Hadipour Moghaddam SP, Ghandehari H, Differential Protein Adsorption and Cellular Uptake of Silica Nanoparticles Based on Size and Porosity. ACS Appl Mater Interfaces 2016 Dec 21;8(50):34820-34832

Jung BK, Lee YK, Hong J, Ghandehari H, Yun CO, Mild Hyperthermia Induced by Gold Nanorod-Mediated Plasmonic Photothermal Therapy Enhances Transduction and Replication of Oncolytic Adenoviral Gene Delivery. ACS Nano 2016 Nov 22;10(11):10533-10543

Frazier N, Payne A, Dillon C, Subrahmanyam N, Ghandehari H, Enhanced efficacy of combination heat shock targeted polymer therapeutics with high intensity focused ultrasound. Nanomedicine 2016 Nov 29;:

Frazier N, Payne A, de Bever J, Dillon C, Panda A, Subrahmanyam N, Ghandehari H, High intensity focused ultrasound hyperthermia for enhanced macromolecular delivery. J Control Release 2016 Nov 10;241:186-193

Poursaid A, Jensen MM, Huo E, Ghandehari H, Polymeric materials for embolic and chemoembolic applications. J Control Release 2016 Oct 28;240:414-433

Mohammadpour R, Safarian S, Buckway B, Ghandehari H, Comparative Endocytosis Mechanisms and Anticancer Effect of HPMA Copolymer- and PAMAM Dendrimer-MTCP Conjugates for Photodynamic Therapy. Macromol Biosci 2016 Oct 25;:

Poursaid A, Jensen MM, Nourbakhsh I, Weisenberger M, Hellgeth JW, Sampath S, Cappello J, Ghandehari H, Silk-Elastinlike Protein Polymer Liquid Chemoembolic for Localized Release of Doxorubicin and Sorafenib. Mol Pharm 2016 Aug 1;13(8):2736-48

Jones DE, Ghandehari H, Facelli JC, A review of the applications of data mining and machine learning for the prediction of biomedical properties of nanoparticles. Comput Methods Programs Biomed 2016 Aug;132:93-103

Mosallaei N, Mahmoudi A, Ghandehari H, Yellepeddi VK, Jaafari MR, Malaekeh-Nikouei B, Solid lipid nanoparticles containing 7-ethyl-10-hydroxycamptothecin (SN38): Preparation, characterization, in vitro, and in vivo evaluations. Eur J Pharm Biopharm 2016 Jul;104:42-50

Yellepeddi VK, Ghandehari H, Poly(amido amine) dendrimers in oral delivery. Tissue Barriers 2016 Apr 6;4(2):e1173773

Jeon HY, Jung SH, Jung YM, Kim YM, Ghandehari H, Ha KS, Array-Based High-Throughput Analysis of Silk-Elastinlike Protein Polymer Degradation and C-Peptide Release by Proteases. Anal Chem 2016 May 17;88(10):5398-405

Robinson R, Gerlach W, Ghandehari H, Comparative effect of gold nanorods and nanocages for prostate tumor hyperthermia. J Control Release 2015 Dec 28;220(Pt A):245-52

Hubbard D, Bond T, Ghandehari H, Regional Morphology and Transport of PAMAM Dendrimers Across Isolated Rat Intestinal Tissue. Macromol Biosci 2015 Dec;15(12):1735-43

Hubbard D, Enda M, Bond T, Moghaddam SP, Conarton J, Scaife C, Volckmann E, Ghandehari H, Transepithelial Transport of PAMAM Dendrimers Across Isolated Human Intestinal Tissue. Mol Pharm 2015 Nov 2;12(11):4099-107

Frazier N, Ghandehari H, Hyperthermia approaches for enhanced delivery of nanomedicines to solid tumors. Biotechnol Bioeng 2015 Oct;112(10):1967-83

Price R, Poursaid A, Cappello J, Ghandehari H, In vivo evaluation of matrix metalloproteinase responsive silk-elastinlike protein polymers for cancer gene therapy. J Control Release 2015 Sep 10;213:96-102

Ghandehari H, ADDR Editor's Collection 2015. Adv Drug Deliv Rev 2015 Aug 30;91:1-2

Gustafson HH, Holt-Casper D, Grainger DW, Ghandehari H, Nanoparticle Uptake: The Phagocyte Problem. Nano Today 2015 Aug;10(4):487-510

Poursaid A, Price R, Tiede A, Olson E, Huo E, McGill L, Ghandehari H, Cappello J, In situ gelling silk-elastinlike protein polymer for transarterial chemoembolization. Biomaterials 2015 Jul;57:142-52

Frazier N, Robinson R, Ray A, Ghandehari H, Effects of heating temperature and duration by gold nanorod mediated plasmonic photothermal therapy on copolymer accumulation in tumor tissue. Mol Pharm 2015 May 4;12(5):1605-14

Jones DE, Ghandehari H, Facelli JC, Predicting cytotoxicity of PAMAM dendrimers using molecular descriptors. Beilstein J Nanotechnol 2015 Sep 11;6:1886-96

Herd HL, Bartlett KT, Gustafson JA, McGill LD, Ghandehari H, Macrophage silica nanoparticle response is phenotypically dependent. Biomaterials 2015;53:574-82

Larson N, Roberts S, Ray A, Buckway B, Cheney DL, Ghandehari H, In vitro synergistic action of geldanamycin- and docetaxel-containing HPMA copolymer-RGDfK conjugates against ovarian cancer. Macromol Biosci 2014 Dec;14(12):1735-47

Price R, Poursaid A, Cappello J, Ghandehari H, Effect of shear on physicochemical properties of matrix metalloproteinase responsive silk-elastinlike hydrogels. J Control Release 2014 Dec 10;195:92-8

Price R, Poursaid A, Ghandehari H, Controlled release from recombinant polymers. J Control Release 2014 Sep 28;190:304-13

Hubbard D, Ghandehari H, Brayden DJ, Transepithelial transport of PAMAM dendrimers across isolated rat jejunal mucosae in ussing chambers. Biomacromolecules 2014 Aug 11;15(8):2889-95

Astashkina AI, Jones CF, Thiagarajan G, Kurtzeborn K, Ghandehari H, Brooks BD, Grainger DW, Nanoparticle toxicity assessment using an in vitro 3-D kidney organoid culture model. Biomaterials 2014 Aug;35(24):6323-31

Ghandehari H, Preface: delivery to the central nervous system using nanoparticles. Adv Drug Deliv Rev 2014 May;71:1

Buckway B, Frazier N, Gormley AJ, Ray A, Ghandehari H, Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors. Nucl Med Biol 2014 Mar;41(3):282-9

Buckway B, Wang Y, Ray A, Ghandehari H, In vitro evaluation of HPMA-copolymers targeted to HER2 expressing pancreatic tumor cells for image guided drug delivery. Macromol Biosci 2014 Jan;14(1):92-9

Sadekar S, Thiagarajan G, Bartlett K, Hubbard D, Ray A, McGill LD, Ghandehari H, Poly(amido amine) dendrimers as absorption enhancers for oral delivery of camptothecin. Int J Pharm 2013 Nov 1;456(1):175-85

Buckway B, Wang Y, Ray A, Ghandehari H, Overcoming the stromal barrier for targeted delivery of HPMA copolymers to pancreatic tumors. Int J Pharm 2013 Nov 1;456(1):202-11

Larson N, Yang J, Ray A, Cheney DL, Ghandehari H, Kopecek J, Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment. Int J Pharm 2013 Sep 15;454(1):435-43

Moos PJ, Honeggar M, Malugin A, Herd H, Thiagarajan G, Ghandehari H, Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications. Mol Pharm 2013 Aug 5;10(8):3242-52

Larson N, Gormley A, Frazier N, Ghandehari H, Synergistic enhancement of cancer therapy using a combination of heat shock protein targeted HPMA copolymer-drug conjugates and gold nanorod induced hyperthermia. J Control Release 2013 Aug 28;170(1):41-50

Sadekar S, Linares O, Noh G, Hubbard D, Ray A, Janát-Amsbury M, Peterson CM, Facelli J, Ghandehari H, COMPARATIVE PHARMACOKINETICS OF PAMAM-OH DENDRIMERS AND HPMA COPOLYMERS IN OVARIAN-TUMOR-BEARING MICE. Drug Deliv Transl Res 2013 Jun 1;3(3):260-271

Thiagarajan G, Greish K, Ghandehari H, Charge affects the oral toxicity of poly(amidoamine) dendrimers. Eur J Pharm Biopharm 2013 Jun;84(2):330-4

Thiagarajan G, Sadekar S, Greish K, Ray A, Ghandehari H, Evidence of oral translocation of anionic G6.5 dendrimers in mice. Mol Pharm 2013 Mar 4;10(3):988-98

Gormley AJ, Larson N, Banisadr A, Robinson R, Frazier N, Ray A, Ghandehari H, Plasmonic photothermal therapy increases the tumor mass penetration of HPMA copolymers. J Control Release 2013 Mar 10;166(2):130-8

Gustafson JA, Price RA, Frandsen J, Henak CR, Cappello J, Ghandehari H, Synthesis and characterization of a matrix-metalloproteinase responsive silk-elastinlike protein polymer. Biomacromolecules 2013 Mar 11;14(3):618-25

Herd H, Daum N, Jones AT, Huwer H, Ghandehari H, Lehr CM, Nanoparticle geometry and surface orientation influence mode of cellular uptake. ACS Nano 2013 Mar 26;7(3):1961-73

Jones CF, Campbell RA, Brooks AE, Assemi S, Tadjiki S, Thiagarajan G, Mulcock C, Weyrich AS, Brooks BD, Ghandehari H, Grainger DW, Cationic PAMAM dendrimers aggressively initiate blood clot formation. ACS Nano 2012 Nov 27;6(11):9900-10

Greish K, Thiagarajan G, Herd H, Price R, Bauer H, Hubbard D, Burckle A, Sadekar S, Yu T, Anwar A, Ray A, Ghandehari H, Size and surface charge significantly influence the toxicity of silica and dendritic nanoparticles. Nanotoxicology 2012 Nov;6(7):713-23

Ghandehari H, Ninth International Nanomedicine and Drug Delivery Symposium. Preface. J Control Release 2012 Oct 10;163(1):1

Yu T, Hubbard D, Ray A, Ghandehari H, In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface characteristics. J Control Release 2012 Oct 10;163(1):46-54

Gormley AJ, Larson N, Sadekar S, Robinson R, Ray A, Ghandehari H, Guided Delivery of Polymer Therapeutics Using Plasmonic Photothermal Therapy. Nano Today 2012 Jun 1;7(3):158-167

Jones CF, Campbell RA, Franks Z, Gibson CC, Thiagarajan G, Vieira-de-Abreu A, Sukavaneshvar S, Mohammad SF, Li DY, Ghandehari H, Weyrich AS, Brooks BD, Grainger DW, Cationic PAMAM dendrimers disrupt key platelet functions. Mol Pharm 2012 Jun 4;9(6):1599-611

Sadekar S, Ghandehari H, Transepithelial transport and toxicity of PAMAM dendrimers: implications for oral drug delivery. Adv Drug Deliv Rev 2012 May 1;64(6):571-88

Price R, Gustafson J, Greish K, Cappello J, McGill L, Ghandehari H, Comparison of silk-elastinlike protein polymer hydrogel and poloxamer in matrix-mediated gene delivery. Int J Pharm 2012 May 1;427(1):97-104

Frandsen JL, Ghandehari H, Recombinant protein-based polymers for advanced drug delivery. Chem Soc Rev 2012 Apr 7;41(7):2696-706

Yu T, Greish K, McGill LD, Ray A, Ghandehari H, Influence of geometry, porosity, and surface characteristics of silica nanoparticles on acute toxicity: their vasculature effect and tolerance threshold. ACS Nano 2012 Mar 27;6(3):2289-301

Larson N, Ghandehari H, Polymeric conjugates for drug delivery. Chem Mater 2012 Mar 13;24(5):840-853

Gormley AJ, Malugin A, Ray A, Robinson R, Ghandehari H, Biological evaluation of RGDfK-gold nanorod conjugates for prostate cancer treatment. J Drug Target 2011 Dec;19(10):915-24

Larson N, Greish K, Bauer H, Maeda H, Ghandehari H, Synthesis and evaluation of poly(styrene-co-maleic acid) micellar nanocarriers for the delivery of tanespimycin. Int J Pharm 2011 Nov 25;420(1):111-7

Gormley AJ, Greish K, Ray A, Robinson R, Gustafson JA, Ghandehari H, Gold nanorod mediated plasmonic photothermal therapy: a tool to enhance macromolecular delivery. Int J Pharm 2011 Aug 30;415(1-2):315-8

Ray A, Larson N, Pike DB, Grüner M, Naik S, Bauer H, Malugin A, Greish K, Ghandehari H, Comparison of active and passive targeting of docetaxel for prostate cancer therapy by HPMA copolymer-RGDfK conjugates. Mol Pharm 2011 Aug 1;8(4):1090-9

Herd HL, Malugin A, Ghandehari H, Silica nanoconstruct cellular toleration threshold in vitro. J Control Release 2011 Jul 15;153(1):40-8

Anumolu R, Gustafson JA, Magda JJ, Cappello J, Ghandehari H, Pease LF 3rd, Fabrication of highly uniform nanoparticles from recombinant silk-elastin-like protein polymers for therapeutic agent delivery. ACS Nano 2011 Jul 26;5(7):5374-82

Yu T, Malugin A, Ghandehari H, Impact of silica nanoparticle design on cellular toxicity and hemolytic activity. ACS Nano 2011 Jul 26;5(7):5717-28

Greish K, Ray A, Bauer H, Larson N, Malugin A, Pike D, Haider M, Ghandehari H, Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release 2011 May 10;151(3):263-70

Arnida, Janát-Amsbury MM, Ray A, Peterson CM, Ghandehari H, Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages. Eur J Pharm Biopharm 2011 Apr;77(3):417-23

Sadekar S, Ray A, Janŕt-Amsbury M, Peterson CM, Ghandehari H, Comparative biodistribution of PAMAM dendrimers and HPMA copolymers in ovarian-tumor-bearing mice. Biomacromolecules 2011 Jan 10;12(1):88-96

Gustafson JA, Ghandehari H, Silk-elastinlike protein polymers for matrix-mediated cancer gene therapy. Adv Drug Deliv Rev 2010 Dec 30;62(15):1509-23

Larson N, Ray A, Malugin A, Pike DB, Ghandehari H, HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res 2010 Dec;27(12):2683-93

Ghandehari H, Hatefi A, Advances in recombinant polymers for delivery of bioactive agents. Adv Drug Deliv Rev 2010 Dec 30;62(15):1403

Thiagarajan G, Ray A, Malugin A, Ghandehari H, PAMAM-camptothecin conjugate inhibits proliferation and induces nuclear fragmentation in colorectal carcinoma cells. Pharm Res 2010 Nov;27(11):2307-16

Vijayalakshmi N, Ray A, Malugin A, Ghandehari H, Carboxyl-terminated PAMAM-SN38 conjugates: synthesis, characterization, and in vitro evaluation. Bioconjug Chem 2010 Oct 20;21(10):1804-10

Dowling MB, Li L, Park J, Kumi G, Nan A, Ghandehari H, Fourkas JT, Deshong P, Multiphoton-Absorption-Induced-Luminescence (MAIL) Imaging of Tumor-Targeted Gold Nanoparticles. Bioconjug Chem 2010 Oct 21;:

Gustafson JA, Price RA, Greish K, Cappello J, Ghandehari H, Silk-elastin-like hydrogel improves the safety of adenovirus-mediated gene-directed enzyme-prodrug therapy. Mol Pharm 2010 Aug 2;7(4):1050-6

Greish K, Frandsen J, Scharff S, Gustafson J, Cappello J, Li D, O'Malley BW Jr, Ghandehari H, Silk-elastinlike protein polymers improve the efficacy of adenovirus thymidine kinase enzyme prodrug therapy of head and neck tumors. J Gene Med 2010 Jul;12(7):572-9

Malugin A, Ghandehari H, Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres. J Appl Toxicol 2010 Apr;30(3):212-7

Pike DB, Ghandehari H, HPMA copolymer-cyclic RGD conjugates for tumor targeting. Adv Drug Deliv Rev 2010 Feb 17;62(2):167-83

Gustafson J, Greish K, Frandsen J, Cappello J, Ghandehari H, Silk-elastinlike recombinant polymers for gene therapy of head and neck cancer: from molecular definition to controlled gene expression. J Control Release 2009 Dec 16;140(3):256-61

Borgman MP, Aras O, Geyser-Stoops S, Sausville EA, Ghandehari H, Biodistribution of HPMA Copolymer-Aminohexylgeldanamycin-RGDfK Conjugates for Prostate Cancer Drug Delivery. Mol Pharm 2009 Oct 1;:

Greish K, Araki K, Li D, O'Malley BW Jr, Dandu R, Frandsen J, Cappello J, Ghandehari H, Silk-elastinlike protein polymer hydrogels for localized adenoviral gene therapy of head and neck tumors. Biomacromolecules 2009 Aug 10;10(8):2183-8

Cresce AV, Dandu R, Burger A, Cappello J, Ghandehari H, Characterization and Real-Time Imaging of Gene Expression of Adenovirus Embedded Silk-Elastinlike Protein Polymer Hydrogels. Mol Pharm 2008 Oct 6;5(5):891-897

Nan A, Bai X, Son SJ, Lee SB, Ghandehari H, Cellular Uptake and Cytotoxicity of Silica Nanotubes. Nano Lett 2008 Aug 13;8(8):2150-2154

Ghandehari H, Materials for advanced drug delivery in the 21st century: a focus area for Advanced Drug Delivery Reviews. Adv Drug Deliv Rev 2008 Jun 10;60(9):956

Kitchens KM, Kolhatkar RB, Swaan PW, Ghandehari H, Endocytosis Inhibitors Prevent Poly(amidoamine) Dendrimer Internalization and Permeability across Caco-2 Cells. Mol Pharm 2008 Mar-Apr;5(2):364-9

Ghandehari H, Kopecková P, Kopecek J, In vitro degradation of pH-sensitive hydrogels containing aromatic azo bonds. Biomaterials 1997 Jun;18(12):861-72

Ghandehari H, Smith PL, Ellens H, Yeh PY, Kopecek J, Size-dependent permeability of hydrophilic probes across rabbit colonic epithelium. J Pharmacol Exp Ther 1997 Feb;280(2):747-53