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Sung Wan  Kim
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Phone: 801-581-6801
Office: 205 BPRB

Sung Wan Kim

Ph.D. Physical Chemistry
University of Utah

Research

Dr. Kim is a pioneer and has been engaged in drug delivery research since 1974 in the areas of hydrogels, biodegradable drug conjugates, self-regulating drug delivery and stimuli sensitive polymers. He has also worked extensively in medical polymers, espe


Selected Publications

Kasala D, Lee SH, Hong JW, Choi JW, Nam K, Chung YH, Kim SW, Yun CO, Synergistic antitumor effect mediated by a paclitaxel-conjugated polymeric micelle-coated oncolytic adenovirus. Biomaterials 2017 Nov;145:207-222

Lecarpentier J, Silvestri V, Kuchenbaecker KB, Barrowdale D, Dennis J, McGuffog L, Soucy P, Leslie G, Rizzolo P, Navazio AS, Valentini V, Zelli V, Lee A, Amin Al Olama A, Tyrer JP, Southey M, John EM, Conner TA, Goldgar DE, Buys SS, Janavicius R, Steele L, Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores. J Clin Oncol 2017 Jul 10;35(20):2240-2250

Phelan CM, Kuchenbaecker KB, Tyrer JP, Kar SP, Lawrenson K, Winham SJ, Dennis J, Pirie A, Riggan MJ, Chornokur G, Earp MA, Lyra PC Jr, Lee JM, Coetzee S, Beesley J, McGuffog L, Soucy P, Dicks E, Lee A, Barrowdale D, Lecarpentier J, Leslie G, Aalfs CM, Abe, Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nat Genet 2017 May;49(5):680-691

Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB, Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers. Mol Pharm 2017 Jan 3;14(1):252-263

Lee E, Kim SW, Enright RD, Beyond Grief and Survival: Posttraumatic Growth Through Immediate Family Suicide Loss in South Korea. Omega (Westport) 2017 Jan 1;:30222817724700

Lee YS, Choi JW, Oh JE, Yun CO, Kim SW, Human relaxin gene expression delivered by bioreducible dendrimer polymer for post-infarct cardiac remodeling in rats. Biomaterials 2016 Aug;97:164-75

Reck M, Luft A, Szczesna A, Havel L, Kim SW, Akerley W, Pietanza MC, Wu YL, Zielinski C, Thomas M, Felip E, Gold K, Horn L, Aerts J, Nakagawa K, Lorigan P, Pieters A, Kong Sanchez T, Fairchild J, Spigel D, Phase III Randomized Trial of Ipilimumab Plus Etoposide and Platinum Versus Placebo Plus Etoposide and Platinum in Extensive-Stage Small-Cell Lung Cancer. J Clin Oncol 2016 Jul 25;:

Kasala D, Yoon AR, Hong J, Kim SW, Yun CO, Evolving lessons on nanomaterial-coated viral vectors for local and systemic gene therapy. Nanomedicine (Lond) 2016 Jul;11(13):1689-713

Madorsky-Feldman D, Sklair-Levy M, Perri T, Laitman Y, Paluch-Shimon S, Schmutzler R, Rhiem K, Lester J, Karlan BY, Singer CF, Van Maerken T, Claes K, Brunet J, Izquierdo A, Teulé A, Lee JW, Kim SW, Arun B, Jakubowska A, Lubinski J, Tucker K, Poplawski NK, An international survey of surveillance schemes for unaffected BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat 2016 Jun;157(2):319-327

Yoon AR, Hong J, Kim SW, Yun CO, Redirecting adenovirus tropism by genetic, chemical, and mechanical modification of the adenovirus surface for cancer gene therapy. Expert Opin Drug Deliv 2016 Jun;13(6):843-58

Lee YS, Joo WS, Kim HS, Kim SW, Human Mesenchymal Stem Cell Delivery System Modulates Ischemic Cardiac Remodeling With an Increase of Coronary Artery Blood Flow. Mol Ther 2016 Apr;24(4):805-11

Won YW, Ankoné M, Engbersen JF, Feijen J, Kim SW, Poly(Amido Amine)s Containing Agmatine and Butanol Side Chains as Efficient Gene Carriers. Macromol Biosci 2016 Apr;16(4):619-26

Silvestri V, Barrowdale D, Mulligan AM, Neuhausen SL, Fox S, Karlan BY, Mitchell G, James P, Thull DL, Zorn KK, Carter NJ, Nathanson KL, Domchek SM, Rebbeck TR, Ramus SJ, Nussbaum RL, Olopade OI, Rantala J, Yoon SY, Caligo MA, Spugnesi L, Bojesen A, Peder, Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res 2016 Feb 9;18(1):15

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akemat, Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016;12(1):1-222

Choi JW, Lee YS, Yun CO, Kim SW, Polymeric oncolytic adenovirus for cancer gene therapy. J Control Release 2015 Dec 10;219:181-191

Na Y, Choi JW, Kasala D, Hong J, Oh E, Li Y, Jung SJ, Kim SW, Yun CO, Potent antitumor effect of neurotensin receptor-targeted oncolytic adenovirus co-expressing decorin and Wnt antagonist in an orthotopic pancreatic tumor model. J Control Release 2015 Dec 28;220(Pt B):766-82

Nam K, Jung S, Nam JP, Kim SW, Poly(ethylenimine) conjugated bioreducible dendrimer for efficient gene delivery. J Control Release 2015 Dec 28;220(Pt A):447-455

Kim H, Nam K, Nam JP, Kim HS, Kim YM, Joo WS, Kim SW, VEGF therapeutic gene delivery using dendrimer type bio-reducible polymer into human mesenchymal stem cells (hMSCs). J Control Release 2015 Dec 28;220(Pt A):222-228

Choi JW, Kim J, Bui QN, Li Y, Yun CO, Lee DS, Kim SW, Tuning Surface Charge and PEGylation of Biocompatible Polymers for Efficient Delivery of Nucleic Acid or Adenoviral Vector. Bioconjug Chem 2015 Aug 19;26(8):1818-29

Choi JW, Nam JP, Nam K, Lee YS, Yun CO, Kim SW, Oncolytic Adenovirus Coated with Multidegradable Bioreducible Core-Cross-Linked Polyethylenimine for Cancer Gene Therapy. Biomacromolecules 2015 Jul 13;16(7):2132-43

Nam JP, Nam K, Nah JW, Kim SW, Evaluation of Histidylated Arginine-Grafted Bioreducible Polymer To Enhance Transfection Efficiency for Use as a Gene Carrier. Mol Pharm 2015 Jul 6;12(7):2352-64

Nam JP, Nam K, Jung S, Nah JW, Kim SW, Evaluation of dendrimer type bio-reducible polymer as a siRNA delivery carrier for cancer therapy. J Control Release 2015 Jul 10;209:179-85

Lee YS, Lim KS, Oh JE, Yoon AR, Joo WS, Kim HS, Yun CO, Kim SW, Development of porous PLGA/PEI1.8k biodegradable microspheres for the delivery of mesenchymal stem cells (MSCs). J Control Release 2015 May 10;205:128-33

Rebbeck TR, Mitra N, Wan F, Sinilnikova OM, Healey S, McGuffog L, Mazoyer S, Chenevix-Trench G, Easton DF, Antoniou AC, Nathanson KL, Laitman Y, Kushnir A, Paluch-Shimon S, Berger R, Zidan J, Friedman E, Ehrencrona H, Stenmark-Askmalm M, Einbeigi Z, Loman, Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. JAMA 2015 Apr 7;313(13):1347-61

Moon CY, Choi JW, Kasala D, Jung SJ, Kim SW, Yun CO, Dual tumor targeting with pH-sensitive and bioreducible polymer-complexed oncolytic adenovirus. Biomaterials 2015 Feb;41:53-68

Won YW, Bull DA, Kim SW, Functional polymers of gene delivery for treatment of myocardial infarct. J Control Release 2014 Dec 10;195:110-9

Lee YS, Kim SW, Bioreducible polymers for therapeutic gene delivery. J Control Release 2014 Sep 28;190:424-39

Kim HA, Nam K, Kim SW, Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery. Biomaterials 2014 Aug;35(26):7543-52

Lee CH, Kasala D, Na Y, Lee MS, Kim SW, Jeong JH, Yun CO, Enhanced therapeutic efficacy of an adenovirus-PEI-bile-acid complex in tumors with low coxsackie and adenovirus receptor expression. Biomaterials 2014 Jul;35(21):5505-16

Florinas S, Kim J, Nam K, Janát-Amsbury MM, Kim SW, Ultrasound-assisted siRNA delivery via arginine-grafted bioreducible polymer and microbubbles targeting VEGF for ovarian cancer treatment. J Control Release 2014 Jun 10;183:1-8

Kim J, Nam HY, Choi JW, Yun CO, Kim SW, Efficient lung orthotopic tumor-growth suppression of oncolytic adenovirus complexed with RGD-targeted bioreducible polymer. Gene Ther 2014 May;21(5):476-83

Moon HH, Joo MK, Mok H, Lee M, Hwang KC, Kim SW, Jeong JH, Choi D, Kim SH, MSC-based VEGF gene therapy in rat myocardial infarction model using facial amphipathic bile acid-conjugated polyethyleneimine. Biomaterials 2014 Feb;35(5):1744-54

Kim PH, Lee M, Nam K, Kim SW, Enhanced Incretin Effects of Exendin-4 Expressing Chimeric Plasmid Based On Two-Step Transcription Amplification System with Dendritic Bioreducible Polymer for the Treatment of Type 2 Diabetes. J Gene Ther 2013 Dec 1;1(1):7-15

Won YW, Lee M, Kim HA, Nam K, Bull DA, Kim SW, Synergistically combined gene delivery for enhanced VEGF secretion and antiapoptosis. Mol Pharm 2013 Oct 7;10(10):3676-83

Kim HA, Nam K, Lee M, Kim SW, Hypoxia/hepatoma dual specific suicide gene expression plasmid delivery using bio-reducible polymer for hepatocellular carcinoma therapy. J Control Release 2013 Oct 10;171(1):1-10

Lee Y, McGinn AN, Olsen CD, Nam K, Lee M, Shin SK, Kim SW, Human erythropoietin gene delivery for cardiac remodeling of myocardial infarction in rats. J Control Release 2013 Oct 10;171(1):24-32

Won YW, McGinn AN, Lee M, Nam K, Bull DA, Kim SW, Post-translational regulation of a hypoxia-responsive VEGF plasmid for the treatment of myocardial ischemia. Biomaterials 2013 Aug;34(26):6229-38

Kim J, Li Y, Kim SW, Lee DS, Yun CO, Therapeutic efficacy of a systemically delivered oncolytic adenovirus - biodegradable polymer complex. Biomaterials 2013 Jun;34(19):4622-31

Florinas S, Nam HY, Kim SW, Enhanced siRNA delivery using a combination of an arginine-grafted bioreducible polymer, ultrasound, and microbubbles in cancer cells. Mol Pharm 2013 May 6;10(5):2021-30

Won YW, McGinn AN, Lee M, Bull DA, Kim SW, Targeted gene delivery to ischemic myocardium by homing peptide-guided polymeric carrier. Mol Pharm 2013 Jan 7;10(1):378-85

Won YW, Lee M, Kim HA, Bull DA, Kim SW, Hypoxia-inducible plasmid expressing both miSHP-1 and HO-1 for the treatment of ischemic disease. J Control Release 2013 Jan 10;165(1):22-8

Nam K, Nam HY, Kim PH, Kim SW, Paclitaxel-conjugated PEG and arginine-grafted bioreducible poly (disulfide amine) micelles for co-delivery of drug and gene. Biomaterials 2012 Nov;33(32):8122-30

Joo WS, Jeong JH, Nam K, Blevins KS, Salama ME, Kim SW, Polymeric delivery of therapeutic RAE-1 plasmid to the pancreatic islets for the prevention of type 1 diabetes. J Control Release 2012 Sep 28;162(3):606-11

Kim PH, Lee M, Kim SW, Delivery of two-step transcription amplification exendin-4 plasmid system with arginine-grafted bioreducible polymer in type 2 diabetes animal model. J Control Release 2012 Aug 20;162(1):9-18

Lee Y, Nam HY, Kim J, Lee M, Yockman JW, Shin SK, Kim SW, Human erythropoietin gene delivery using an arginine-grafted bioreducible polymer system. Mol Ther 2012 Jul;20(7):1360-6

Won YW, Lee M, Kim HA, Bull DA, Kim SW, Post-translational regulated and hypoxia-responsible VEGF plasmid for efficient secretion. J Control Release 2012 Jun 28;160(3):525-31

Nam HY, Nam K, Lee M, Kim SW, Bull DA, Dendrimer type bio-reducible polymer for efficient gene delivery. J Control Release 2012 Jun 28;160(3):592-600

Nam HY, Kim J, Kim SW, Bull DA, Cell targeting peptide conjugation to siRNA polyplexes for effective gene silencing in cardiomyocytes. Mol Pharm 2012 May 7;9(5):1302-9

Brumbach JH, Lee YW, Kim SW, Yockman JW, Functional properties and biodistribution of poly(triethylenetetramine/cystamine bisacrylamide) and poly(triethylenetetramine/cystamine bisacrylamide)- poly(ethylene glycol) mixtures formed with nucleic acid. J Control Release 2012 Apr 10;159(1):111-9

Kim J, Kim PH, Nam HY, Lee JS, Yun CO, Kim SW, Linearized oncolytic adenoviral plasmid DNA delivered by bioreducible polymers. J Control Release 2012 Mar 28;158(3):451-60

Kim J, Kim PH, Kim SW, Yun CO, Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials. Biomaterials 2012 Feb;33(6):1838-50

Nam HY, Lee Y, Lee M, Shin SK, Kim TI, Kim SW, Bull DA, Erythropoietin gene delivery using an arginine-grafted bioreducible polymer system. J Control Release 2012 Feb 10;157(3):437-44

Blevins KS, Jeong JH, Ou M, Brumbach JH, Kim SW, EphA2 targeting peptide tethered bioreducible poly(cystamine bisacrylamide-diamino hexane) for the delivery of therapeutic pCMV-RAE-1? to pancreatic islets. J Control Release 2012 Feb 28;158(1):115-22

Kim PH, Kim SW, Polymer-based delivery of glucagon-like Peptide-1 for the treatment of diabetes. ISRN Endocrinol 2012;2012:340632

Kim PH, Kim J, Kim TI, Nam HY, Yockman JW, Kim M, Kim SW, Yun CO, Bioreducible polymer-conjugated oncolytic adenovirus for hepatoma-specific therapy via systemic administration. Biomaterials 2011 Dec;32(35):9328-42

Kim SW, Biomaterials to gene delivery. J Control Release 2011 Oct 30;155(2):116-8

Nam HY, Kim J, Kim S, Yockman JW, Kim SW, Bull DA, Cell penetrating peptide conjugated bioreducible polymer for siRNA delivery. Biomaterials 2011 Aug;32(22):5213-22

Kim SW, Polymeric gene delivery for diabetic treatment. Diabetes Metab J 2011 Aug;35(4):317-26

Kim J, Nam HY, Kim TI, Kim PH, Ryu J, Yun CO, Kim SW, Active targeting of RGD-conjugated bioreducible polymer for delivery of oncolytic adenovirus expressing shRNA against IL-8 mRNA. Biomaterials 2011 Aug;32(22):5158-66

McGinn AN, Nam HY, Ou M, Hu N, Straub CM, Yockman JW, Bull DA, Kim SW, Bioreducible polymer-transfected skeletal myoblasts for VEGF delivery to acutely ischemic myocardium. Biomaterials 2011 Jan;32(3):942-9

Nam HY, McGinn A, Kim PH, Kim SW, Bull DA, Primary cardiomyocyte-targeted bioreducible polymer for efficient gene delivery to the myocardium. Biomaterials 2010 Nov;31(31):8081-7

Brumbach JH, Lin C, Yockman J, Kim WJ, Blevins KS, Engbersen JF, Feijen J, Kim SW, Mixtures of poly(triethylenetetramine/cystamine bisacrylamide) and poly(triethylenetetramine/cystamine bisacrylamide)-g-poly(ethylene glycol) for improved gene delivery. Bioconjug Chem 2010 Oct 20;21(10):1753-61

Borden BA, Yockman J, Kim SW, Thermoresponsive hydrogel as a delivery scaffold for transfected rat mesenchymal stem cells. Mol Pharm 2010 Aug 2;7(4):963-8

Kim SH, Ou M, Bull DA, Kim SW, Reductive degradation behavior of bioreducible poly(disulfide amine) for enhancing SiRNA efficiency. Macromol Biosci 2010 Aug 11;10(8):898-905

Kim TI, Lee M, Kim SW, A guanidinylated bioreducible polymer with high nuclear localization ability for gene delivery systems. Biomaterials 2010 Mar;31(7):1798-804

Ou M, Kim TI, Yockman JW, Borden BA, Bull DA, Kim SW, Polymer transfected primary myoblasts mediated efficient gene expression and angiogenic proliferation. J Control Release 2010 Feb 25;142(1):61-9

Jeong JH, Kim SH, Christensen LV, Feijen J, Kim SW, Reducible Poly(amido ethylenimine)-Based Gene Delivery System for Improved Nucleus Trafficking of Plasmid DNA. Bioconjug Chem 2010 Jan 15;:

Jeong JH, Kim SH, Lee M, Kim WJ, Park TG, Ko KS, Kim SW, Non-viral systemic delivery of Fas siRNA suppresses cyclophosphamide-induced diabetes in NOD mice. J Control Release 2010 Jan 15;:

Ou M, Xu R, Kim SH, Bull DA, Kim SW, A family of bioreducible poly(disulfide amine)s for gene delivery. Biomaterials 2009 Oct;30(29):5804-14

Janát-Amsbury MM, Peterson CM, Kim SW, The role of gene- and drug delivery in women's health--unmet clinical needs and future opportunities. Preface. Adv Drug Deliv Rev 2009 Aug 10;61(10):767

Yockman JW, Kim SW, Bull DA, Women and heart disease--physiologic regulation of gene delivery and expression: bioreducible polymers and ischemia-inducible gene therapies for the treatment of ischemic heart disease. Adv Drug Deliv Rev 2009 Aug 10;61(10):863-70

Kim SH, Jeong JH, Kim TI, Kim SW, Bull DA, VEGF siRNA delivery system using arginine-grafted bioreducible poly(disulfide amine). Mol Pharm 2009 May-Jun;6(3):718-26

Kim TI, Ou M, Lee M, Kim SW, Arginine-grafted bioreducible poly(disulfide amine) for gene delivery systems. Biomaterials 2009 Feb;30(4):658-64

Yockman JW, Choi D, Whitten MG, Chang CW, Kastenmeier A, Erickson H, Albanil A, Lee M, Kim SW, Bull DA, Polymeric gene delivery of ischemia-inducible VEGF significantly attenuates infarct size and apoptosis following myocardial infarct. Gene Ther 2009 Jan;16(1):127-35

Yockman JW, Kastenmeier A, Erickson HM, Brumbach JG, Whitten MG, Albanil A, Li DY, Kim SW, Bull DA, Novel polymer carriers and gene constructs for treatment of myocardial ischemia and infarction. J Control Release 2008 Dec 18;132(3):260-6

Kim SH, Jeong JH, Ou M, Yockman JW, Kim SW, Bull DA, Cardiomyocyte-targeted siRNA delivery by prostaglandin E(2)-Fas siRNA polyplexes formulated with reducible poly(amido amine) for preventing cardiomyocyte apoptosis. Biomaterials 2008 Nov;29(33):4439-46

Kim SH, Jeong JH, Lee SH, Kim SW, Park TG, LHRH Receptor-Mediated Delivery of siRNA Using Polyelectrolyte Complex Micelles Self-Assembled from siRNA-PEG-LHRH Conjugate and PEI. Bioconjug Chem 2008 Oct 14;:

Mossalam M, Jeong JH, Abel ED, Kim SW, Kim YH, Reversal of oxidative stress in endothelial cells by controlled release of adiponectin. J Control Release 2008 Sep 24;130(3):234-7

Ou M, Wang XL, Xu R, Chang CW, Bull DA, Kim SW, Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity. Bioconjug Chem 2008 Mar;19(3):626-33

Chang CW, Christensen LV, Lee M, Kim SW, Efficient expression of vascular endothelial growth factor using minicircle DNA for angiogenic gene therapy. J Control Release 2008 Jan 22;125(2):155-63

Yockman JW, Kim WJ, Chang CW, Kim SW, Non-viral delivery of interleukin-2 and soluble Flk-1 inhibits metastatic and primary tumor growth in renal cell carcinoma. Gene Ther 2007 Oct;14(19):1399-405

Zhou J, Yockman JW, Kim SW, Kern SE, Intracellular kinetics of non-viral gene delivery using polyethylenimine carriers. Pharm Res 2007 Jun;24(6):1079-87

Chang CW, Choi D, Kim WJ, Yockman JW, Christensen LV, Kim YH, Kim SW, Non-ionic amphiphilic biodegradable PEG-PLGA-PEG copolymer enhances gene delivery efficiency in rat skeletal muscle. J Control Release 2007 Apr 2;118(2):245-53

Kim WJ, Chang CW, Lee M, Kim SW, Efficient siRNA delivery using water soluble lipopolymer for anti-angiogenic gene therapy. J Control Release 2007 Apr 23;118(3):357-63

Christensen LV, Chang CW, Yockman JW, Conners R, Jackson H, Zhong Z, Feijen J, Bull DA, Kim SW, Reducible poly(amido ethylenediamine) for hypoxia-inducible VEGF delivery. J Control Release 2007 Apr 2;118(2):254-61

Kim SH, Jeong JH, Mok H, Lee SH, Kim SW, Park TG, Folate Receptor Targeted Delivery of Polyelectrolyte Complex Micelles Prepared from ODN-PEG-Folate Conjugate and Cationic Lipids. Biotechnol Prog 2007 Feb 2;23(1):232-237

Jo S, Kim J, Kim SW, Reverse thermal gelation of aliphatically modified biodegradable triblock copolymers. Macromol Biosci 2006 Nov 9;6(11):923-8

Christensen LV, Chang CW, Kim WJ, Kim SW, Zhong Z, Lin C, Engbersen JF, Feijen J, Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery. Bioconjug Chem 2006 Sep-Oct;17(5):1233-40

Kim WJ, Yockman JW, Jeong JH, Christensen LV, Lee M, Kim YH, Kim SW, Anti-angiogenic inhibition of tumor growth by systemic delivery of PEI-g-PEG-RGD/pCMV-sFlt-1 complexes in tumor-bearing mice. J Control Release 2006 Sep 12;114(3):381-8

Kim WJ, Christensen LV, Jo S, Yockman JW, Jeong JH, Kim YH, Kim SW, Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma. Mol Ther 2006 Sep;14(3):343-50

Park JH, Lee M, Kim SW, Non-viral adiponectin gene therapy into obese type 2 diabetic mice ameliorates insulin resistance. J Control Release 2006 Aug 10;114(1):118-25

Shim WS, Kim SW, Lee D , Sulfonamide-Based pH- and Temperature-Sensitive Biodegradable Block Copolymer Hydrogels. Biomacromolecules 2006 Jun;7(6):1935-41

Choi S, Oh S, Lee M, Kim SW, Glucagon-like peptide-1 plasmid construction and delivery for the treatment of type 2 diabetes. Mol Ther 2005 Nov;12(5):885-91

Jeong JH, Lee M, Kim WJ, Yockman JW, Park TG, Kim YH, Kim SW, Anti-GAD antibody targeted non-viral gene delivery to islet beta cells. J Control Release 2005 Oct 20;107(3):562-70

Kim WJ, Yockman JW, Lee M, Jeong JH, Kim YH, Kim SW, Soluble Flt-1 gene delivery using PEI-g-PEG-RGD conjugate for anti-angiogenesis. J Control Release 2005 Aug 18;106(1-2):224-34

Kim YH, Park JH, Lee M, Kim YH, Park TG, Kim SW, Polyethylenimine with acid-labile linkages as a biodegradable gene carrier. J Control Release 2005 Mar 2;103(1):209-19

Bikram M, Lee M, Chang CW, Janát-Amsbury MM, Kern SE, Kim SW, Long-circulating DNA-complexed biodegradable multiblock copolymers for gene delivery: degradation profiles and evidence of dysopsonization. J Control Release 2005 Mar 2;103(1):221-33

Kim SW, Terplex gene delivery system. Adv Genet 2005;53:263-74

Janát-Amsbury MM, Yockman JW, Lee M, Kern S, Furgeson DY, Bikram M, Kim SW, Local, non-viral IL-12 gene therapy using a water soluble lipopolymer as carrier system combined with systemic paclitaxel for cancer treatment. J Control Release 2005 Jan 3;101(1-3):273-85

Kim SW, Terplex Gene Delivery System. Adv Genet 2005;53PA:263-274

Lee M, Kim SW, Polyethylene glycol-conjugated copolymers for plasmid DNA delivery. Pharm Res 2005 Jan;22(1):1-10

Masaki T, Rathi R, Zentner G, Leypoldt JK, Mohammad SF, Burns GL, Li L, Zhuplatov S, Chirananthavat T, Kim SJ, Kern S, Holman J, Kim SW, Cheung AK, Inhibition of neointimal hyperplasia in vascular grafts by sustained perivascular delivery of paclitaxel. Kidney Int 2004 Nov;66(5):2061-9

Chae SY, Kim YY, Kim SW, Bae YH, Prolonged glucose normalization of streptozotocin-induced diabetic mice by transplantation of rat islets coencapsulated with crosslinked hemoglobin. Transplantation 2004 Aug 15;78(3):392-7

Lee JS, Lee M, Kim SW, A new potent hFIX plasmid for hemophilia B gene therapy. Pharm Res 2004 Jul;21(7):1229-32

Furgeson DY, Yockman JW, Janat MM, Kim SW, Tumor efficacy and biodistribution of linear polyethylenimine-cholesterol/DNA complexes. Mol Ther 2004 Jun;9(6):837-45

Janát-Amsbury MM, Yockman JW, Lee M, Kern S, Furgeson DY, Bikram M, Kim SW, Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model. Mol Ther 2004 Jun;9(6):829-36

Choi S, Baudys M, Kim SW, Control of blood glucose by novel GLP-1 delivery using biodegradable triblock copolymer of PLGA-PEG-PLGA in type 2 diabetic rats. Pharm Res 2004 May;21(5):827-31

Kwon YM, Kim SW, Biodegradable triblock copolymer microspheres based on thermosensitive sol-gel transition. Pharm Res 2004 Feb;21(2):339-43

Choi S, Kim SW, Controlled release of insulin from injectable biodegradable triblock copolymer depot in ZDF rats. Pharm Res 2003 Dec;20(12):2008-10

Bull DA, Bailey SH, Rentz JJ, Zebrack JS, Lee M, Litwin SE, Kim SW, Effect of Terplex/VEGF-165 gene therapy on left ventricular function and structure following myocardial infarction. VEGF gene therapy for myocardial infarction. J Control Release 2003 Dec 5;93(2):175-81

Furgeson DY, Chan WS, Yockman JW, Kim SW, Modified linear polyethylenimine-cholesterol conjugates for DNA complexation. Bioconjug Chem 2003 Jul-Aug;14(4):840-7

Lee M, Rentz J, Han SO, Bull DA, Kim SW, Water-soluble lipopolymer as an efficient carrier for gene delivery to myocardium. Gene Ther 2003 Apr;10(7):585-93

Lee M, Ko KS, Oh S, Kim SW, Prevention of autoimmune insulitis by delivery of a chimeric plasmid encoding interleukin-4 and interleukin-10. J Control Release 2003 Mar 7;88(2):333-42

Yockman JW, Maheshwari A, Han SO, Kim SW, Tumor regression by repeated intratumoral delivery of water soluble lipopolymers/p2CMVmIL-12 complexes. J Control Release 2003 Feb 21;87(1-3):177-86

Suh W, Han SO, Yu L, Kim SW, An angiogenic, endothelial-cell-targeted polymeric gene carrier. Mol Ther 2002 Nov;6(5):664-72

Maheshwari A, Han S, Mahato RI, Kim SW, Biodegradable polymer-based interleukin-12 gene delivery: role of induced cytokines, tumor infiltrating cells and nitric oxide in anti-tumor activity. Gene Ther 2002 Aug;9(16):1075-84

Hinds KD, Kim SW, Effects of PEG conjugation on insulin properties. Adv Drug Deliv Rev 2002 Jun 17;54(4):505-30

Furgeson DY, Cohen RN, Mahato RI, Kim SW, Novel water insoluble lipoparticulates for gene delivery. Pharm Res 2002 Apr;19(4):382-90

Ahn CH, Chae SY, Bae YH, Kim SW, Biodegradable poly(ethylenimine) for plasmid DNA delivery. J Control Release 2002 Apr 23;80(1-3):273-82

Sagara K, Kim SW, A new synthesis of galactose-poly(ethylene glycol)-polyethylenimine for gene delivery to hepatocytes. J Control Release 2002 Feb 19;79(1-3):271-81

Benns JM, Mahato RI, Kim SW, Optimization of factors influencing the transfection efficiency of folate-PEG-folate-graft-polyethylenimine. J Control Release 2002 Feb 19;79(1-3):255-69

Kwon YM, Baudys M, Knutson K, Kim SW, In situ study of insulin aggregation induced by water-organic solvent interface. Pharm Res 2001 Dec;18(12):1754-9

Larson RS, Menard V, Jacobs H, Kim SW, Physicochemical characterization of poly(ethylene glycol)-modified anti-GAD antibodies. Bioconjug Chem 2001 Nov-Dec;12(6):861-9

Lee M, Han SO, Ko KS, Koh JJ, Park JS, Yoon JW, Kim SW, Repression of GAD autoantigen expression in pancreas beta-Cells by delivery of antisense plasmid/PEG-g-PLL complex. Mol Ther 2001 Oct;4(4):339-46

Ko KS, Lee M, Koh JJ, Kim SW, Combined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice. Mol Ther 2001 Oct;4(4):313-6

Yu L, Suh H, Koh JJ, Kim SW, Systemic administration of TerplexDNA system: pharmacokinetics and gene expression. Pharm Res 2001 Sep;18(9):1277-83

Lee M, Han S, Ko KS, Kim SW, Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymer. J Control Release 2001 Aug 10;75(3):421-9

Mahato RI, Lee M, Han S, Maheshwari A, Kim SW, Intratumoral delivery of p2CMVmIL-12 using water-soluble lipopolymers. Mol Ther 2001 Aug;4(2):130-8

Suh W, Chung JK, Park SH, Kim SW, Anti-JL1 antibody-conjugated poly (L-lysine) for targeted gene delivery to leukemia T cells. J Control Release 2001 May 14;72(1-3):171-8

Han So, Mahato RI, Kim SW, Water-soluble lipopolymer for gene delivery. Bioconjug Chem 2001 May-Jun;12(3):337-45

Benns JM, Maheshwari A, Furgeson DY, Mahato RI, Kim SW, Folate-PEG-folate-graft-polyethylenimine-based gene delivery. J Drug Target 2001 Apr;9(2):123-39

Kim YJ, Choi S, Koh JJ, Lee M, Ko KS, Kim SW, Controlled release of insulin from injectable biodegradable triblock copolymer. Pharm Res 2001 Apr;18(4):548-50

Lee M, Nah JW, Kwon Y, Koh JJ, Ko KS, Kim SW, Water-soluble and low molecular weight chitosan-based plasmid DNA delivery. Pharm Res 2001 Apr;18(4):427-31

Affleck DG, Yu L, Bull DA, Bailey SH, Kim SW, Augmentation of myocardial transfection using TerplexDNA: a novel gene delivery system. Gene Ther 2001 Mar;8(5):349-53

Gappa H, Baudys M, Koh JJ, Kim SW, Bae YH, The effect of zinc-crystallized glucagon-like peptide-1 on insulin secretion of macroencapsulated pancreatic islets. Tissue Eng 2001 Feb;7(1):35-44

Chae SY, Kim SW, Bae YH, Bioactive polymers for biohybrid artificial pancreas. J Drug Target 2001;9(6):473-84

Koh JJ, Ko KS, Lee M, Han S, Park JS, Kim SW, Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice. Gene Ther 2000 Dec;7(24):2099-104

Benns JM, Choi JS, Mahato RI, Park JS, Kim SW, pH-sensitive cationic polymer gene delivery vehicle: N-Ac-poly(L-histidine)-graft-poly(L-lysine) comb shaped polymer. Bioconjug Chem 2000 Sep-Oct;11(5):637-45

Han S, Mahato RI, Sung YK, Kim SW, Development of biomaterials for gene therapy. Mol Ther 2000 Oct;2(4):302-17

Maheshwari A, Mahato RI, McGregor J, Han So, Samlowski WE, Park JS, Kim SW, Soluble biodegradable polymer-based cytokine gene delivery for cancer treatment. Mol Ther 2000 Aug;2(2):121-30

Vernon B, Kim SW, Bae YH, Thermoreversible copolymer gels for extracellular matrix. J Biomed Mater Res 2000 Jul;51(1):69-79

Hinds K, Koh JJ, Joss L, Liu F, Baudys M, Kim SW, Synthesis and characterization of poly(ethylene glycol)-insulin conjugates. Bioconjug Chem 2000 Mar-Apr;11(2):195-201

Jeong B, Bae YH, Kim SW, In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof. J Biomed Mater Res 2000 May;50(2):171-7

Jeong B, Bae YH, Kim SW, Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J Control Release 2000 Jan 3;63(1-2):155-63

Benns JM, Kim SW, Tailoring new gene delivery designs for specific targets. J Drug Target 2000;8(1):1-12

Ramkissoon-Ganorkar C, Baudys M, Kim SW, Effect of ionic strength on the loading efficiency of model polypeptide/protein drugs in pH-/temperature-sensitive polymers. J Biomater Sci Polym Ed 2000;11(1):45-54

Jeong B, Choi YK, Bae YH, Zentner G, Kim SW, New biodegradable polymers for injectable drug delivery systems. J Control Release 1999 Nov 1;62(1-2):109-14

Menard V, Jacobs H, Jun HS, Yoon JW, Kim SW, Anti-GAD monoclonal antibody delays the onset of diabetes mellitus in NOD mice. Pharm Res 1999 Jul;16(7):1059-66

von Recum HA, Okano T, Kim SW, Bernstein PS, Maintenance of retinoid metabolism in human retinal pigment epithelium cell culture. Exp Eye Res 1999 Jul;69(1):97-107

von Recum H, Kikuchi A, Yamato M, Sakurai Y, Okano T, Kim SW, Growth factor and matrix molecules preserve cell function on thermally responsive culture surfaces. Tissue Eng 1999 Jun;5(3):251-65

Ramkissoon-Ganorkar C, Gutowska A, Liu F, Baudys M, Kim SW, Polymer molecular weight alters properties of pH-/temperature-sensitive polymeric beads. Pharm Res 1999 Jun;16(6):819-27

Ramkissoon-Ganorkar C, Liu F, Baudys M, Kim SW, Modulating insulin-release profile from pH/thermosensitive polymeric beads through polymer molecular weight. J Control Release 1999 Jun 2;59(3):287-98

Uchio T, Baudys M, Liu F, Song SC, Kim SW, Site-specific insulin conjugates with enhanced stability and extended action profile. Adv Drug Deliv Rev 1999 Feb 1;35(2-3):289-306

Vernon B, Kim SW, Bae YH, Insulin release from islets of Langerhans entrapped in a poly(N-isopropylacrylamide-co-acrylic acid) polymer gel. J Biomater Sci Polym Ed 1999;10(2):183-98

Ramkissoon-Ganorkar C, Liu F, Baudys M, Kim SW, Effect of molecular weight and polydispersity on kinetics of dissolution and release from ph/temperature-sensitive polymers. J Biomater Sci Polym Ed 1999;10(10):1149-61

Suh H, Jeong B, Rathi R, Kim SW, Regulation of smooth muscle cell proliferation using paclitaxel-loaded poly(ethylene oxide)-poly(lactide/glycolide) nanospheres. J Biomed Mater Res 1998 Nov;42(2):331-8

Suh H, Jeong B, Liu F, Kim SW, Cellular uptake study of biodegradable nanoparticles in vascular smooth muscle cells. Pharm Res 1998 Sep;15(9):1495-8

von Recum HA, Kim SW, Kikuchi A, Okuhara M, Sakurai Y, Okano T, Novel thermally reversible hydrogel as detachable cell culture substrate. J Biomed Mater Res 1998 Jun 15;40(4):631-9

Baudys M, Letourneur D, Liu F, Mix D, Jozefonvicz J, Kim SW, Extending insulin action in vivo by conjugation to carboxymethyl dextran. Bioconjug Chem 1998 Mar-Apr;9(2):176-83

Kim JS, Kim BI, Maruyama A, Akaike T, Kim SW, A new non-viral DNA delivery vector: the terplex system. J Control Release 1998 Apr 30;53(1-3):175-82

Kim JS, Maruyama A, Akaike T, Kim SW, Terplex DNA delivery system as a gene carrier. Pharm Res 1998 Jan;15(1):116-21

von Recum H, Kikuchi A, Okuhara M, Sakurai Y, Okano T, Kim SW, Retinal pigmented epithelium cultures on thermally responsive polymer porous substrates. J Biomater Sci Polym Ed 1998;9(11):1241-53

Liu F, Song SC, Mix D, Baudys M, Kim SW, Glucose-induced release of glycosylpoly(ethylene glycol) insulin bound to a soluble conjugate of concanavalin A. Bioconjug Chem 1997 Sep-Oct;8(5):664-72

Jeong B, Bae YH, Lee DS, Kim SW, Biodegradable block copolymers as injectable drug-delivery systems. Nature 1997 Aug 28;388(6645):860-2

Byun Y, Jacobs HA, Kim SW, Binding of antithrombin III and thrombin to immobilized heparin under flow conditions. Biotechnol Prog 1996 Mar-Apr;12(2):217-25

Patel R, Jacobs HA, Kim SW, Surface adsorption and fibrinogen interactions with hirudin-thrombin complex. J Biomed Mater Res 1996 Sep;32(1):11-8

Byun Y, Jacobs HA, Kim SW, Mechanism of thrombin inactivation by immobilized heparin. J Biomed Mater Res 1996 Apr;30(4):423-7

Serres A, Baudys M, Kim SW, Temperature and pH-sensitive polymers for human calcitonin delivery. Pharm Res 1996 Feb;13(2):196-201

Kim SW, Jacobs H, Design of nonthrombogenic polymer surfaces for blood-contacting medical devices. Blood Purif 1996;14(5):357-72

Byun Y, Jacobs HA, Feijen J, Kim SW, Effect of fibronectin on the binding of antithrombin III to immobilized heparin. J Biomed Mater Res 1996 Jan;30(1):95-100

Gutowska A, Bae YH, Jacobs H, Mohammad F, Mix D, Feijen J, Kim SW, Heparin release from thermosensitive polymer coatings: in vivo studies. J Biomed Mater Res 1995 Jul;29(7):811-21

Kim SW, Ryu GH, Lee I, Koh JJ, Min BG, Lee HK, Adhered platelet morphology in diabetes mellitus. Diabete Metab 1995 Feb;21(1):50-3

Baudys M, Uchio T, Mix D, Wilson D, Kim SW, Physical stabilization of insulin by glycosylation. J Pharm Sci 1995 Jan;84(1):28-33

Yang Y, Jacobs H, Bae YH, Kim SW, Selective protein transport through a thin cellulose coated porous membrane. Biotechnol Bioeng 1994 Feb 5;43(3):207-14

Byun Y, Jacobs HA, Kim SW, Heparin surface immobilization through hydrophilic spacers: thrombin and antithrombin III binding kinetics. J Biomater Sci Polym Ed 1994;6(1):1-13

Pai CM, Jacobs H, Bae YH, Kim SW, Synthesis and characterization of soluble concanavalin A oligomer. Biotechnol Bioeng 1993 Apr 25;41(10):957-63

Ma X, Mohammad SF, Kim SW, Interaction of heparin with polyallylamine-immobilized surfaces. J Biomed Mater Res 1993 Mar;27(3):357-65

Piao AZ, Jacobs HA, Park KD, Kim SW, Heparin immobilization by surface amplification. ASAIO J 1992 Jul-Sep;38(3):M638-43

Byun Y, Jacobs HA, Kim SW, Binding kinetics of thrombin and antithrombin III with immobilized heparin using a spacer. ASAIO J 1992 Jul-Sep;38(3):M649-53

Ma X, Mohammad SF, Kim SW, Heparin removal from blood using poly(L-lysine) immobilized hollow fiber. Biotechnol Bioeng 1992 Aug 5;40(4):530-6

Pai CM, Bae YH, Mack EJ, Wilson DE, Kim SW, Concanavalin A microspheres for a self-regulating insulin delivery system. J Pharm Sci 1992 Jun;81(6):532-6

Park KD, Kim WG, Jacobs H, Okano T, Kim SW, Blood compatibility of SPUU-PEO-heparin graft copolymers. J Biomed Mater Res 1992 Jun;26(6):739-56

Kim SW, Bae YH, Okano T, Hydrogels: swelling, drug loading, and release. Pharm Res 1992 Mar;9(3):283-90

Kwon IC, Bae YH, Kim SW, Electrically erodible polymer gel for controlled release of drugs. Nature 1991 Nov 28;354(6351):291-3

Komada F, Imanidis G, Miyajima M, Okano T, Durrani MJ, Higuchi WI, Kim SW, Shannon WM, Baker DC, Design of 9-beta-D-arabinofuranosyladenine (ara-A) transdermal delivery system for animal studies: regulation of drug concentration in vivo. J Pharm Sci 1991 Oct;80(10):935-41

Lin SC, Jacobs HA, Kim SW, Heparin immobilization increased through chemical amplification. J Biomed Mater Res 1991 Jun;25(6):791-5

Bae YH, Okano T, Kim SW, "On-off" thermocontrol of solute transport. II. Solute release from thermosensitive hydrogels. Pharm Res 1991 May;8(5):624-8

Li XL, Adams NW, Bennett DB, Feijen J, Kim SW, Synthesis of poly(hydroxypropylglutamine-prazosin carbamate) and release studies. Pharm Res 1991 Apr;8(4):527-30

Bae YH, Okano T, Kim SW, "On-off" thermocontrol of solute transport. I. Temperature dependence of swelling of N-isopropylacrylamide networks modified with hydrophobic components in water. Pharm Res 1991 Apr;8(4):531-7

Makino K, Mack EJ, Okano T, Kim SW, Self-regulated delivery of insulin from microcapsules. Biomater Artif Cells Immobilization Biotechnol 1991;19(1):219-28

Nojiri C, Park KD, Grainger DW, Jacobs HA, Okano T, Koyanagi H, Kim SW, In vivo nonthrombogenicity of heparin immobilized polymer surfaces. ASAIO Trans 1990 Jul-Sep;36(3):M168-72

Nojiri C, Okano T, Jacobs HA, Park KD, Mohammad SF, Olsen DB, Kim SW, Blood compatibility of PEO grafted polyurethane and HEMA/styrene block copolymer surfaces. J Biomed Mater Res 1990 Sep;24(9):1151-71

Gilbert DL, Kim SW, Macromolecular release from collagen monolithic devices. J Biomed Mater Res 1990 Sep;24(9):1221-39

Grainger DW, Okano T, Kim SW, Castner DG, Ratner BD, Briggs D, Sung YK, Poly(dimethylsiloxane)-poly(ethylene oxide)-heparin block copolymers. III: Surface and bulk compositional differences. J Biomed Mater Res 1990 May;24(5):547-71

Grainger DW, Knutson K, Kim SW, Feijen J, Poly(dimethylsiloxane)-poly(ethylene oxide)-heparin block copolymers. II: Surface characterization and in vitro assessments. J Biomed Mater Res 1990 Apr;24(4):403-31

Nojiri C, Kim SW, Jacobs HA, Pantalos GM, Olsen DB, Scanning and transmission electron microscopic evaluation of the U-100 total artificial heart blood contacting surface. ASAIO Trans 1989 Jul-Sep;35(3):679-83

Nojiri C, Park KD, Okano T, Kim SW, In vivo protein adsorption onto polymers: a transmission electron microscopic study. ASAIO Trans 1989 Jul-Sep;35(3):357-61

Piao AZ, Nojiri C, Park KD, Jacobs H, Feijen J, Kim SW, Synthesis and characterization of poly(dimethylsiloxane)-poly(ethylene oxide)-heparin CBABC type block copolymers. J Biomater Sci Polym Ed 1990;1(4):299-313

Grainger DW, Nojiri C, Okano T, Kim SW, In vitro and ex vivo platelet interactions with hydrophilic-hydrophobic poly(ethylene oxide)-polystyrene multiblock copolymers. J Biomed Mater Res 1989 Sep;23(9):979-1005

Jacobs HA, Okano T, Kim SW, Antithrombogenic surfaces: characterization and bioactivity of surface immobilized PGE1-heparin conjugate. J Biomed Mater Res 1989 Jun;23(6):611-30

Mohammad SF, Kim SW, Olsen DB, Heparin neutralization of antiplatelet effect of aspirin and dipyridamole. ASAIO Trans 1988 Jul-Sep;34(3):322-7

Nojiri C, Okano T, Park KD, Kim SW, Suppression mechanisms for thrombus formation on heparin-immobilized segmented polyurethane-ureas. ASAIO Trans 1988 Jul-Sep;34(3):386-98

Jacobs H, Grainger D, Okano T, Kim SW, Surface modification for improved blood compatibility. Artif Organs 1988 Dec;12(6):506-7

Park KD, Okano T, Nojiri C, Kim SW, Heparin immobilization onto segmented polyurethane-urea surfaces--effect of hydrophilic spacers. J Biomed Mater Res 1988 Nov;22(11):977-92

Grainger DW, Kim SW, Feijen J, Poly(dimethylsiloxane)-poly(ethylene oxide)-heparin block copolymers. I. Synthesis and characterization. J Biomed Mater Res 1988 Mar;22(3):231-49

Nojiri C, Okano T, Grainger D, Park KD, Nakahama S, Suzuki K, Kim SW, Evaluation of nonthrombogenic polymers in a new rabbit A-A shunt model. ASAIO Trans 1987 Jul-Sep;33(3):596-601

Lin JY, Nojiri C, Okano T, Kim SW, Minimum heparin release rate for nonthrombogenicity. ASAIO Trans 1987 Jul-Sep;33(3):602-5

Negishi N, Bennett DB, Cho CS, Jeong SY, Van Heeswijk WA, Feijen J, Kim SW, Coupling of naltrexone to biodegradable poly(alpha-amino acids). Pharm Res 1987 Aug;4(4):305-10

Kim SW, Jacobs H, Lin JY, Nojori C, Okano T, Nonthrombogenic bioactive surfaces. Ann N Y Acad Sci 1987;516:116-30

Kim SW, Jhon MS, Ree T, Eyring H, The surface tension of binary liquid mixtures. Proc Natl Acad Sci U S A 1968 Feb;59(2):336-42