Lab

Research

Selected Publications

Segerson NM, Daccarett M, Badger TJ, Shabaan A, Akoum N, Fish EN, Rao S, Burgon NS, Adjei-Poku Y, Kholmovski E, Vijayakumar S, Dibella EV, Macleod RS, Marrouche NF, Magnetic Resonance Imaging-Confirmed Ablative Debulking of the Left Atrial Posterior Wall and Septum for Treatment of Persistent Atrial Fibrillation: Rationale and Initial Experience. J Cardiovasc Electrophysiol 2009 Oct 5;():

Lew S, Wolters CH, Anwander A, Makeig S, MacLeod RS, Improved EEG source analysis using low-resolution conductivity estimation in a four-compartment finite element head model. Hum Brain Mapp 2009 Sep;30(9):2862-78

Macleod RS, Stinstra JG, Lew S, Whitaker RT, Swenson DJ, Cole MJ, Krüger J, Brooks DH, Johnson CR, Subject-specific, multiscale simulation of electrophysiology: a software pipeline for image-based models and application examples. Philos Transact A Math Phys Eng Sci 2009 Jun 13;367(1896):2293-310

Oakes RS, Badger TJ, Kholmovski EG, Akoum N, Burgon NS, Fish EN, Blauer JJ, Rao SN, DiBella EV, Segerson NM, Daccarett M, Windfelder J, McGann CJ, Parker D, MacLeod RS, Marrouche NF, Detection and quantification of left atrial structural remodeling with delayed-enhancement magnetic resonance imaging in patients with atrial fibrillation. Circulation 2009 Apr 7;119(13):1758-67

Badger TJ, Oakes RS, Daccarett M, Burgon NS, Akoum N, Fish EN, Blauer JJ, Rao SN, Adjei-Poku Y, Kholmovski EG, Vijayakumar S, Di Bella EV, MacLeod RS, Marrouche NF, Temporal left atrial lesion formation after ablation of atrial fibrillation. Heart Rhythm 2009 Feb;6(2):161-8

Isaacson BM, Stinstra JG, MacLeod RS, Webster JB, Beck JP, Bloebaum RD, Bioelectric analyses of an osseointegrated intelligent implant design system for amputees. J Vis Exp 2009 Jul 15;(29):1-6

Sutherland DR, Ni Q, MacLeod RS, Lux RL, Punske BB, Experimental measures of ventricular activation and synchrony. Pacing Clin Electrophysiol 2008 Dec;31(12):1560-70

McGann CJ, Kholmovski EG, Oakes RS, Blauer JJ, Daccarett M, Segerson N, Airey KJ, Akoum N, Fish E, Badger TJ, DiBella EV, Parker D, MacLeod RS, Marrouche NF, New magnetic resonance imaging-based method for defining the extent of left atrial wall injury after the ablation of atrial fibrillation. J Am Coll Cardiol 2008 Oct 7;52(15):1263-71

Taccardi B, Punske BB, Macchi E, Macleod RS, Ershler PR, Epicardial and intramural excitation during ventricular pacing: effect of myocardial structure. Am J Physiol Heart Circ Physiol 2008 Apr;294(4):H1753-66

Geneser SE, Kirby RM, MacLeod RS, Application of stochastic finite element methods to study the sensitivity of ECG forward modeling to organ conductivity. IEEE Trans Biomed Eng 2008 Jan;55(1):31-40

Shome S, Lux RL, Punske BB, MacLeod RS, Ischemic preconditioning protects against arrhythmogenesis through maintenance of both active as well as passive electrical properties in ischemic canine hearts. J Electrocardiol 2007 Nov-Dec;40(6 Suppl):S150-9

Yilmaz B, MacLeod R , Generalized training subset selection for statistical estimation of epicardial activation maps from intravenous catheter measurements. Comput Biol Med 2007 Mar;37(3):328-36

Ghodrati A, Brooks DH, MacLeod R , Methods of solving reduced lead systems for inverse electrocardiography. IEEE Trans Biomed Eng 2007 Feb;54(2):339-43

Stinstra JG, Jolley M, Callahan M, Weinstein D, Cole M, Brooks DH, Triedman J, MacLeod RS, Evaluation of different meshing algorithms in the computation of defibrillation thresholds in children. Conf Proc IEEE Eng Med Biol Soc 2007;2007():1422-5

Serinagaoglu Y, Brooks DH, MacLeod R , Improved performance of bayesian solutions for inverse electrocardiography using multiple information sources. IEEE Trans Biomed Eng 2006 Oct;53(10):2024-34

Ghodrati A, Brooks DH, Tadmor G, MacLeod R , Wavefront-based models for inverse electrocardiography. IEEE Trans Biomed Eng 2006 Sep;53(9):1821-31

Wolters CH, Anwander A, Tricoche X, Weinstein D, Koch MA, MacLeod R , Influence of tissue conductivity anisotropy on EEG/MEG field and return current computation in a realistic head model: a simulation and visualization study using high-resolution finite element modeling. Neuroimage 2006 Apr 15;30(3):813-26

Stinstra J, Roberts S, Pormann J, Macleod R, Henriquez , A Model of 3D Propagation in Discrete Cardiac Tissue. Comput Cardiol 2006;33():41-44

Stinstra JG, Hopenfeld B, Macleod RS, On the passive cardiac conductivity. Ann Biomed Eng 2005 Dec;33(12):1743-51

Yilmaz B, MacLeod RS, Punske BB, Taccardi B, Brooks D , Venous catheter based mapping of ectopic epicardial activation: training data set selection for statistical estimation. IEEE Trans Biomed Eng 2005 Nov;52(11):1823-31

Stinstra JG, Shome S, Hopenfeld B, MacLeod RS, Modelling passive cardiac conductivity during ischaemia. Med Biol Eng Comput 2005 Nov;43(6):776-82

MacLeod RS, Shome S, Stinstra J, Punske BB, Hopenfeld B, Mechanisms of ischemia-induced ST-segment changes. J Electrocardiol 2005 Oct;38(4 Suppl):8-13

Hopenfeld B, Stinstra JG, MacLeod RS, The effect of conductivity on ST-segment epicardial potentials arising from subendocardial ischemia. Ann Biomed Eng 2005 Jun;33(6):751-63

Hopenfeld B, Stinstra JG, Macleod RS, Mechanism for ST depression associated with contiguous subendocardial ischemia. J Cardiovasc Electrophysiol 2004 Oct;15(10):1200-6

Wolters CH, Anwander A, Maess B, Macleod RS, Friederici AD, The influence of volume conduction effects on the EEG/MEG reconstruction of the sources of the Early Left Anterior Negativity. Conf Proc IEEE Eng Med Biol Soc 2004;5():3569-72

Shome S, Stinstra JG, Hopenfeld B, Punske BB, Macleod RS, A study of the dynamics of cardiac ischemia using experimental and modeling approaches. Conf Proc IEEE Eng Med Biol Soc 2004;5():3585-8

Yilmaz B, MacLeod RS, Venous catheter based mapping of epicardial ectopic activation. Conf Proc IEEE Eng Med Biol Soc 2004;2():1002-5

Stinstra JG, Hopenfeld B, Macleod RS, Using models of the passive cardiac conductivity and full heart anisotropic bidomain to study the epicardial potentials in ischemia. Conf Proc IEEE Eng Med Biol Soc 2004;5():3555-8

Punske BB, Ni Q, Lux RL, MacLeod RS, Ershler PR, Dustman TJ, Allison MJ, Taccardi B, Spatial methods of epicardial activation time determination in normal hearts. Ann Biomed Eng 2003 Jul-Aug;31(7):781-92

MacLeod RS, Punske B, Yilmaz B, Shome S, Taccardi B, The role of heart rate in myocardial ischemia from restricted coronary perfusion. J Electrocardiol 2001;34 Suppl():43-51

Fuller MS, Sándor G, Punske B, Taccardi B, MacLeod RS, Ershler PR, Green LS, Lux RL, Estimates of repolarization dispersion from electrocardiographic measurements. Circulation 2000 Aug 8;102(6):685-91

Fuller MS, Sándor G, Punske B, Taccardi B, MacLeod RS, Ershler PR, Green LS, Lux RL, Estimates of repolarization and its dispersion from electrocardiographic measurements: direct epicardial assessment in the canine heart. J Electrocardiol 2000 Apr;33(2):171-80

MacLeod RS, Ni Q, Punske B, Ershler PR, Yilmaz B, Taccardi B, Effects of heart position on the body-surface electrocardiogram. J Electrocardiol 2000;33 Suppl():229-37

Ni Q, MacLeod RS, Punske BB, Taccardi B, Computing and visualizing electric potentials and current pathways in the thorax. J Electrocardiol 2000;33 Suppl():189-97

Punske BB, Lux RL, MacLeod RS, Fuller MS, Ershler PR, Dustman TJ, Vyhmeister Y, Taccardi B, Mechanisms of the spatial distribution of QT intervals on the epicardial and body surfaces. J Cardiovasc Electrophysiol 1999 Dec;10(12):1605-18

Ni Q, MacLeod RS, Lux RL, Three-dimensional activation mapping in ventricular muscle: interpolation and approximation of activation times. Ann Biomed Eng 1999 Sep-Oct;27(5):617-26

Kuenzler RO, MacLeod RS, Taccardi B, Ni Q, Lux RL, Estimation of epicardial activation maps from intravascular recordings. J Electrocardiol 1999 Apr;32(2):77-92

Lux RL, Fuller MS, MacLeod RS, Ershler PR, Punske BB, Taccardi B, Noninvasive indices of repolarization and its dispersion. J Electrocardiol 1999;32 Suppl():153-7

Ni Q, MacLeod RS, Lux RL, Taccardi B, A novel interpolation method for electric potential fields in the heart during excitation. Ann Biomed Eng 1998 Jul-Aug;26(4):597-607

Taccardi B, Punske BB, Lux RL, MacLeod RS, Ershler PR, Dustman TJ, Vyhmeister Y, Useful lessons from body surface mapping. J Cardiovasc Electrophysiol 1998 Jul;9(7):773-86

MacLeod RS, Brooks DH, Recent progress in inverse problems in electrocardiology. IEEE Eng Med Biol Mag 1998 Jan-Feb;17(1):73-83

Lux RL, Fuller MS, MacLeod RS, Ershler PR, Green LS, Taccardi B, QT interval dispersion: dispersion of ventricular repolarization or dispersion of QT interval? J Electrocardiol 1998;30 Suppl():176-80

MacLeod RS, Lux RL, Taccardi B, A possible mechanism for electrocardiographically silent changes in cardiac repolarization. J Electrocardiol 1998;30 Suppl():114-21

Johnson CR, MacLeod RS, Adaptive local regularization methods for the inverse ECG problem. Prog Biophys Mol Biol 1998;69(2-3):405-23

Klepfer RN, Johnson CR, Macleod RS, The effects of inhomogeneities and anisotropies on electrocardiographic fields: a 3-D finite-element study. IEEE Trans Biomed Eng 1997 Aug;44(8):706-19

MacLeod RS, Lux RL, Fuller MS, Taccardi B, Evaluation of novel measurement methods for detecting heterogeneous repolarization. J Electrocardiol 1996;29 Suppl():145-53

Taccardi B, Lux RL, MacLeod RS, Ershler PR, Dustman TJ, Scott M, Vyhmeister Y, Ingebrigtsen N, ECG waveforms and cardiac electric sources. J Electrocardiol 1996;29 Suppl():98-100

MacLeod RS, Lux RL, Errors in ECG parameter estimation from standard leadsets. J Electrocardiol 1995;28 Suppl():98-103

Lux RL, MacLeod RS, Fuller M, Green LS, Kornreich F, Estimating ECG distributions from small numbers of leads. J Electrocardiol 1995;28 Suppl():92-8

MacLeod RS, Gardner M, Miller RM, Horácek BM, Application of an electrocardiographic inverse solution to localize ischemia during coronary angioplasty. J Cardiovasc Electrophysiol 1995 Jan;6(1):2-18

MacLeod RS, Brooks DH, On H, Krim H, Lux RL, Kornreich F, Analysis of PTCA-induced ischemia using an ECG inverse solution or the wavelet transform. J Electrocardiol 1994;27 Suppl():93-100

Lux RL, Green LS, MacLeod RS, Taccardi B, Assessment of spatial and temporal characteristics of ventricular repolarization. J Electrocardiol 1994;27 Suppl():100-5

Johnson CR, MacLeod RS, Ershler PR, A computer model for the study of electrical current flow in the human thorax. Comput Biol Med 1992 Sep;22(5):305-23