Selected Publications

Wiles ET, Lui-Sargent B, Bell R, Lessnick SL, BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma. PLoS One 2013;8(3):e59369

Evans CH, Liu F, Porter RM, O'Sullivan RP, Merghoub T, Lunsford EP, Robichaud K, Van Valen F, Lessnick SL, Gebhardt MC, Wells JW, EWS-FLI-1-Targeted Cytotoxic T-cell Killing of Multiple Tumor Types Belonging to the Ewing Sarcoma Family of Tumors. Clin Cancer Res 2012 Oct 1;18(19):5341-51

Jahromi MS, Putnam AR, Druzgal C, Wright J, Spraker-Perlman H, Kinsey M, Zhou H, Boucher KM, Randall RL, Jones KB, Lucas D, Rosenberg A, Thomas D, Lessnick SL, Schiffman JD, Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma. Cancer Genet 2012 Jul-Aug;205(7-8):391-404

Beck R, Monument MJ, Watkins WS, Smith R, Boucher KM, Schiffman JD, Jorde LB, Randall RL, Lessnick SL, EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations. Cancer Genet 2012 Jun;205(6):304-12

Luo W, Milash B, Dalley B, Smith R, Zhou H, Dutrow N, Cairns BR, Lessnick SL, Antibody detection of translocations in Ewing sarcoma. EMBO Mol Med 2012 Jun;4(6):453-61

Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle MC, The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma. Genes Cancer 2012 Feb;3(2):102-16

Monument MJ, Lessnick SL, Schiffman JD, Randall RT, Microsatellite instability in sarcoma: fact or fiction? ISRN Oncol 2012;2012():473146

Spraker HL, Price SL, Chaturvedi A, Schiffman JD, Jones KB, Lessnick SL, Beckerle M, Randall RL, The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm. Front Oncol 2012;2():2

Calvert GT, Randall RL, Jones KB, Cannon-Albright L, Lessnick S, Schiffman JD, At-risk populations for osteosarcoma: the syndromes and beyond. Sarcoma 2012;2012():152382

Lessnick SL, Ladanyi M, Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets. Annu Rev Pathol 2012;7():145-59

Jones KB, Haldar M, Schiffman JD, Cannon-Albright L, Lessnick SL, Sharma S, Capecchi MR, Randall RL, Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation. Cancer Control 2011 Jul;18(3):196-203

Sankar S, Lessnick SL, Promiscuous partnerships in Ewing's sarcoma. Cancer Genet 2011 Jul;204(7):351-65

Jones KB, Schiffman JD, Kohlmann W, Randall RL, Lessnick SL, Cannon-Albright LA, Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes. Cancer Epidemiol Biomarkers Prev 2011 May;20(5):751-7

Luo W, Kinsey M, Schiffman JD, Lessnick SL, Glutathione s-transferases in pediatric cancer. Front Oncol 2011;1():39

Kowalewski AA, Randall RL, Lessnick SL, Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis. Sarcoma 2011;2011():598704

Joyner DE, Jones KB, Lessnick SL, Schiffman JD, Randall RL, Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas. Sarcoma 2011;2011():847409

Gangwal K, Close D, Enriquez CA, Hill CP, Lessnick SL, Emergent Properties of EWS/FLI Regulation via GGAA Microsatellites in Ewing's Sarcoma. Genes Cancer 2010 Feb 1;1(2):177-187

Randall RL, Lessnick SL, Jones KB, Gouw LG, Cummings JE, Cannon-Albright L, Schiffman JD, Is There a Predisposition Gene for Ewing's Sarcoma? J Oncol 2010;2010():397632

Kinsey M, Smith R, Iyer AK, McCabe ER, Lessnick SL, EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma. Cancer Res 2009 Dec 1;69(23):9047-55

Luo W, Gangwal K, Sankar S, Boucher KM, Thomas D, Lessnick SL, GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance. Oncogene 2009 Nov 19;28(46):4126-32

Gangwal K, Lessnick SL, Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure. Cell Cycle 2008 Oct;7(20):3127-32

Gangwal K, Sankar S, Hollenhorst PC, Kinsey M, Haroldsen SC, Shah AA, Boucher KM, Watkins WS, Jorde LB, Graves BJ, Lessnick SL, Microsatellites as EWS/FLI response elements in Ewing's sarcoma. Proc Natl Acad Sci U S A 2008 Jul 22;105(29):10149-54

Hancock JD, Lessnick SL, A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature. Cell Cycle 2008 Jan 15;7(2):250-6

Owen LA, Kowalewski AA, Lessnick SL, EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma. PLoS One 2008 Apr 16;3(4):e1965

Haldar M, Hancock JD, Coffin CM, Lessnick SL, Capecchi MR, A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell 2007 Apr;11(4):375-88

Braunreiter CL, Hancock JD, Coffin CM, Boucher KM, Lessnick SL, Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma. Cell Cycle 2006 Dec;5(23):2753-9

Kinsey M, Smith R, Lessnick SL, NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. Mol Cancer Res 2006 Nov;4(11):851-9

Owen LA, Lessnick SL, Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma. Cell Cycle 2006 Sep;5(18):2049-53

Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, Lessnick SL, Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell 2006 May;9(5):405-16