Research

Current Research

Selected Publications

Kim SE, Jeong EK, Shi XF, Morrell G, Treiman GS, Parker DL, Diffusion-weighted imaging of human carotid artery using 2D single-shot interleaved multislice inner volume diffusion-weighted echo planar imaging (2D ss-IMIV-DWEPI) at 3T: diffusion measurement in atherosclerotic plaque. J Magn Reson Imaging 2009 Nov;30(5):1068-77

Feng Y, Emerson L, Jeong EK, Parker DL, Lu ZR, Application of a biodegradable macromolecular contrast agent in dynamic contrast-enhanced MRI for assessing the efficacy of indocyanine green-enhanced photothermal cancer therapy. J Magn Reson Imaging 2009 Aug;30(2):401-6

Shi X, Kholmovski EG, Kim SE, Parker DL, Jeong EK, Improvement of accuracy of diffusion MRI using real-time self-gated data acquisition. NMR Biomed 2009 Jun;22(5):545-50

Zong Y, Wang X, Jeong EK, Parker DL, Lu ZR, Structural effect on degradability and in vivo contrast enhancement of polydisulfide Gd(III) complexes as biodegradable macromolecular MRI contrast agents. Magn Reson Imaging 2009 May;27(4):503-11

Goodrich KC, Hadley JR, Moon SM, Chronik BA, Scholl TJ, Debever JT, Parker DL, Design, Fabrication and Testing of an Insertable Double-Imaging-Region Gradient Coil. Concepts Magn Reson Part B Magn Reson Eng 2009 Apr 1;35B(2):98-105

Mendes J, Kholmovski E, Parker DL, Rigid-body motion correction with self-navigation MRI. Magn Reson Med 2009 Mar;61(3):739-47

Terry CM, Kim SE, Li L, Goodrich KC, Hadley JR, Blumenthal DK, Parker DL, Cheung AK, Longitudinal assessment of hyperplasia using magnetic resonance imaging without contrast in a porcine arteriovenous graft model. Acad Radiol 2009 Jan;16(1):96-107

Zhang L, Kholmovski EG, Guo J, Choi SE, Morrell GR, Parker DL, HASTE sequence with parallel acquisition and T2 decay compensation: application to carotid artery imaging. Magn Reson Imaging 2009 Jan;27(1):13-22

Payne AH, Goodrich KC, Kholmovski EG, Roemer RB, Parker DL, Isolated kidney phantom for development of biothermal vascular models with application to high intensity focused ultrasound therapy. Med Phys 2008 Oct;35(10):4426-34

Kaneshiro TL, Jeong EK, Morrell G, Parker DL, Lu ZR, Synthesis and evaluation of globular Gd-DOTA-monoamide conjugates with precisely controlled nanosizes for magnetic resonance angiography. Biomacromolecules 2008 Oct;9(10):2742-8

Schabel MC, Parker DL, Uncertainty and bias in contrast concentration measurements using spoiled gradient echo pulse sequences. Phys Med Biol 2008 May 7;53(9):2345-73

Guo JY, Kholmovski EG, Zhang L, Parker DL, Evaluation of motion effects on parallel MR imaging with precalibration. Magn Reson Imaging 2007 Oct;25(8):1130-7

Xu R, Wang Y, Wang X, Jeong EK, Parker DL, Lu ZR, In Vivo evaluation of a PAMAM-cystamine-(Gd-DO3A) conjugate as a biodegradable macromolecular MRI contrast agent. Exp Biol Med (Maywood) 2007 Sep;232(8):1081-9

Mohs AM, Nguyen T, Jeong EK, Feng Y, Emerson L, Zong Y, Parker DL, Lu ZR, Modification of Gd-DTPA cystine copolymers with PEG-1000 optimizes pharmacokinetics and tissue retention for magnetic resonance angiography. Magn Reson Med 2007 Jul;58(1):110-8

Phatak NS, Sun Q, Kim SE, Parker DL, Sanders RK, Veress AI, Ellis BJ, Weiss JA, Noninvasive determination of ligament strain with deformable image registration. Ann Biomed Eng 2007 Jul;35(7):1175-87

Wang Y, Ye F, Jeong EK, Sun Y, Parker DL, Lu ZR, Noninvasive visualization of pharmacokinetics, biodistribution and tumor targeting of poly[N-(2-hydroxypropyl)methacrylamide] in mice using contrast enhanced MRI. Pharm Res 2007 Jun;24(6):1208-16

Zhang L, Kholmovski EG, Guo J, Parker DL, TSE with average-specific phase encoding ordering for motion detection and artifact suppression. J Magn Reson Imaging 2007 Jun;25(6):1271-82

Ke T, Jeong EK, Wang X, Feng Y, Parker DL, Lu ZR, RGD targeted poly(L-glutamic acid)-cystamine-(Gd-DO3A) conjugate for detecting angiogenesis biomarker alpha(v) beta3 integrin with MRT, mapping. Int J Nanomedicine 2007;2(2):191-9

Jeong EK, Kim SE, Kholmovski EG, Parker DL, High-resolution DTI of a localized volume using 3D single-shot diffusion-weighted STimulated echo-planar imaging (3D ss-DWSTEPI). Magn Reson Med 2006 Dec;56(6):1173-81

Parker DL, Hadley JR, Multiple-region gradient arrays for extended field of view, increased performance, and reduced nerve stimulation in magnetic resonance imaging. Magn Reson Med 2006 Dec;56(6):1251-60

Ke T, Feng Y, Guo J, Parker DL, Lu ZR, Biodegradable cystamine spacer facilitates the clearance of Gd(III) chelates in poly(glutamic acid) Gd-DO3A conjugates for contrast-enhanced MR imaging. Magn Reson Imaging 2006 Sep;24(7):931-40

Guo JY, Kholmovski EG, Zhang L, Jeong EK, Parker DL, k-space inherited parallel acquisition (KIPA): application on dynamic magnetic resonance imaging thermometry. Magn Reson Imaging 2006 Sep;24(7):903-15

Feng Y, Zong Y, Ke T, Jeong EK, Parker DL, Lu ZR, Pharmacokinetics, biodistribution and contrast enhanced MR blood pool imaging of Gd-DTPA cystine copolymers and Gd-DTPA cystine diethyl ester copolymers in a rat model. Pharm Res 2006 Aug;23(8):1736-42

Kaneshiro TL, Ke T, Jeong EK, Parker DL, Lu ZR, Gd-DTPA L-cystine bisamide copolymers as novel biodegradable macromolecular contrast agents for MR blood pool imaging. Pharm Res 2006 Jun;23(6):1285-94

Zong Y, Guo J, Ke T, Mohs AM, Parker DL, Lu ZR, Effect of size and charge on pharmacokinetics and in vivo MRI contrast enhancement of biodegradable polydisulfide Gd(III) complexes. J Control Release 2006 May 30;112(3):350-6

Jeong EK, Kim SE, Guo J, Kholmovski EG, Parker DL, High-resolution DTI with 2D interleaved multislice reduced FOV single-shot diffusion-weighted EPI (2D ss-rFOV-DWEPI). Magn Reson Med 2005 Dec;54(6):1575-9

Di Bella EV, Parker DL, Sinusas AJ, On the dark rim artifact in dynamic contrast-enhanced MRI myocardial perfusion studies. Magn Reson Med 2005 Nov;54(5):1295-9

Zhang L, Chapman BE, Parker DL, Roberts JA, Guo J, Vemuri P, Moon SM, Noo F, Automatic detection of three-dimensional vascular tree centerlines and bifurcations in high-resolution magnetic resonance angiography. Invest Radiol 2005 Oct;40(10):661-71

Mohs AM, Zong Y, Guo J, Parker DL, Lu ZR, PEG-g-poly(GdDTPA-co-L-cystine): effect of PEG chain length on in vivo contrast enhancement in MRI. Biomacromolecules 2005 Jul-Aug;6(4):2305-11

Kholmovski EG, Parker DL, Application of phase consistency to improve time efficiency and image quality in dual echo black-blood carotid angiography. Magn Reson Imaging 2005 Jul;23(6):711-22

Hadley JR, Roberts JA, Goodrich KC, Buswell HR, Parker DL, Relative RF coil performance in carotid imaging. Magn Reson Imaging 2005 Jun;23(5):629-39

Guo JY, Kim SE, Parker DL, Jeong EK, Zhang L, Roemer RB, Improved accuracy and consistency in T1 measurement of flowing blood by using inversion recovery GE-EPI. Med Phys 2005 Apr;32(4):1083-93

Zong Y, Wang X, Goodrich KC, Mohs AM, Parker DL, Lu ZR, Contrast-enhanced MRI with new biodegradable macromolecular Gd(III) complexes in tumor-bearing mice. Magn Reson Med 2005 Apr;53(4):835-42

Vemuri P, Kholmovski EG, Parker DL, Chapman BE, Coil sensitivity estimation for optimal SNR reconstruction and intensity inhomogeneity correction in phased array MR imaging. Inf Process Med Imaging 2005;19():603-14

Samsonov AA, Kholmovski EG, Parker DL, Johnson CR, POCSENSE: POCS-based reconstruction for sensitivity encoded magnetic resonance imaging. Magn Reson Med 2004 Dec;52(6):1397-406

Kim SE, Kholmovski EG, Jeong EK, Buswell HR, Tsuruda JS, Parker DL, Triple contrast technique for black blood imaging with double inversion preparation. Magn Reson Med 2004 Dec;52(6):1379-87

Mohs AM, Wang X, Goodrich KC, Zong Y, Parker DL, Lu ZR, PEG-g-poly(GdDTPA-co-L-cystine): a biodegradable macromolecular blood pool contrast agent for MR imaging. Bioconjug Chem 2004 Nov-Dec;15(6):1424-30

Wang D, Miller SC, Sima M, Parker D, Buswell H, Goodrich KC, Kopeckova P, Kopecek , The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study. Pharm Res 2004 Oct;21(10):1741-9

Vemuri P, Kholmovski EG, Goodrich KC, Zhang L, Tsuruda JS, Parker DL, Statistics-based approach for aneurysm volume measurements. J Magn Reson Imaging 2004 Aug;20(2):340-6

Farnham JM, Camp NJ, Neuhausen SL, Tsuruda J, Parker D, MacDonald J, Cannon-Albright L , Confirmation of chromosome 7q11 locus for predisposition to intracranial aneurysm. Hum Genet 2004 Feb;114(3):250-5

Lu ZR, Parker DL, Goodrich KC, Wang X, Dalle JG, Buswell HR, Extracellular biodegradable macromolecular gadolinium(III) complexes for MRI. Magn Reson Med 2004 Jan;51(1):27-34

Jeong EK, Kim SE, Parker DL, High-resolution diffusion-weighted 3D MRI, using diffusion-weighted driven-equilibrium (DW-DE) and multishot segmented 3D-SSFP without navigator echoes. Magn Reson Med 2003 Oct;50(4):821-9

Green D, Parker , CTA and MRA: visualization without catheterization. Semin Ultrasound CT MR 2003 Aug;24(4):185-91

Parker DL, Goodrich KC, Roberts JA, Chapman BE, Jeong EK, Kim SE, Tsuruda JS, Katzman GL, The need for phase-encoding flow compensation in high-resolution intracranial magnetic resonance angiography. J Magn Reson Imaging 2003 Jul;18(1):121-7

Lu ZR, Wang X, Parker DL, Goodrich KC, Buswell HR, Poly(l-glutamic acid) Gd(III)-DOTA conjugate with a degradable spacer for magnetic resonance imaging. Bioconjug Chem 2003 Jul-Aug;14(4):715-9

Di Bella EV, Wu YJ, Alexander AL, Parker DL, Green D, McGann CJ, Comparison of temporal filtering methods for dynamic contrast MRI myocardial perfusion studies. Magn Reson Med 2003 May;49(5):895-902

Jeong EK, Parker DL, Tsuruda JS, Won JY, Reduction of flow-related signal loss in flow-compensated 3D TOF MR angiography, using variable echo time (3D TOF-VTE). Magn Reson Med 2002 Oct;48(4):667-76

Wu Y, Jeong EK, Parker DL, Alexander AL, UNFOLD using a temporal subtraction and spectral energy comparison technique. Magn Reson Med 2002 Sep;48(3):559-64

Kholmovski EG, Samsonov AA, Parker DL, Motion artifact reduction technique for dual-contrast FSE imaging. Magn Reson Imaging 2002 Jul;20(6):455-62

Kholmovski EG, Alexander AL, Parker DL, Correction of slab boundary artifact using histogram matching. J Magn Reson Imaging 2002 May;15(5):610-7

Parker DL, Goodrich KC, Masiker M, Tsuruda JS, Katzman GL, Improved efficiency in double-inversion fast spin-echo imaging. Magn Reson Med 2002 May;47(5):1017-21

Hasan KM, Parker DL, Alexander AL, Comparison of gradient encoding schemes for diffusion-tensor MRI. J Magn Reson Imaging 2001 May;13(5):769-80

Lee JN, Roberts JA, Parker DL, Tsuruda JS, Intensity correction by subtraction for phased-array MRA images. J Magn Reson Imaging 2000 Sep;12(3):501-4

Alexander AL, Hasan K, Kindlmann G, Parker DL, Tsuruda JS, A geometric analysis of diffusion tensor measurements of the human brain. Magn Reson Med 2000 Aug;44(2):283-91

Kholmovski EG, Parker DL, Alexander AL, A generalized k-sampling scheme for 3D fast spin echo. J Magn Reson Imaging 2000 May;11(5):549-58

Parker DL, Chapman BE, Roberts JA, Alexander AL, Tsuruda JS, Enhanced image detail using continuity in the MIP Z-buffer: applications to magnetic resonance angiography. J Magn Reson Imaging 2000 Apr;11(4):378-88

Hadley JR, Chapman BE, Roberts JA, Chapman DC, Goodrich KC, Buswell HR, Alexander AL, Tsuruda JS, Parker DL, A three-coil comparison for MR angiography. J Magn Reson Imaging 2000 Apr;11(4):458-68

Alexander AL, Chapman BE, Tsuruda JS, Parker DL, A median filter for 3D FAST spin echo black blood images of cerebral vessels. Magn Reson Med 2000 Feb;43(2):310-3

Chapman BE, Goodrich CK, Alexander AL, Blatter DD, Parker DL, Evaluation of measures of technical image quality for intracranial magnetic resonance angiography. Comput Biomed Res 1999 Dec;32(6):530-56

Parker DL, Roberts JA, Alexander AL, Goodrich KC, Tsuruda J, Magnetic resonance angiography with sliding interleaved projection reconstruction (SLIPR) acquisition. J Magn Reson Imaging 1999 Oct;10(4):569-75

Parker DL, Goodrich KC, Alexander AL, Buswell HR, Blatter DD, Tsuruda JS, Optimized visualization of vessels in contrast enhanced intracranial MR angiography. Magn Reson Med 1998 Dec;40(6):873-82

Parker DL, Tsuruda JS, Goodrich KC, Alexander AL, Buswell HR, Contrast-enhanced magnetic resonance angiography of cerebral arteries. A review. Invest Radiol 1998 Sep;33(9):560-72

Alexander AL, Buswell HR, Sun Y, Chapman BE, Tsuruda JS, Parker DL, Intracranial black-blood MR angiography with high-resolution 3D fast spin echo. Magn Reson Med 1998 Aug;40(2):298-310

Alexander AL, Tsuruda JS, Parker DL, Elimination of eddy current artifacts in diffusion-weighted echo-planar images: the use of bipolar gradients. Magn Reson Med 1997 Dec;38(6):1016-21

Muhlestein JB, Zhang Q, Parker DJ, Horn SD, Parker DL, Anderson JL, A comparison of the accuracy and reproducibility of digital three-dimensional coronary artery reconstructions using edge detection or videodensitometry. Comput Biomed Res 1997 Dec;30(6):415-26

Du YP, Parker DL, Vessel enhancement filtering in three-dimensional MR angiograms using long-range signal correlation. J Magn Reson Imaging 1997 Mar-Apr;7(2):447-50

Wan X, Gullberg GT, Parker DL, Zeng GL, Reduction of geometric and intensity distortions in echo-planar imaging using a multireference scan. Magn Reson Med 1997 Jun;37(6):932-42

Huang SP, Decker RJ, Goodrich KC, Parker DJ, Muhlestein JB, Blatter DD, Parker DL, Velocity measurement based on bolus tracking with the aid of three-dimensional reconstruction from digital subtraction angiography. Med Phys 1997 May;24(5):677-86

Chapman BE, Sanderson AR, Goodrich KC, Alexander AL, Blatter DD, Parker DL, Observer performance methodologies for evaluating blood vessel visibility in MR angiograms using accurate geometric registration to high resolution x-ray angiograms. Magn Reson Med 1997 Apr;37(4):519-29

Du YP, Parker DL, Studies on the performance of circular and elliptical Z-gradient coils using a simulated annealing algorithm. Magn Reson Imaging 1997;15(2):255-62

Lee JN, King BD, Parker DL, Buswell HR, Harnsberger HR, High resolution 3D imaging of the inner ear with a modified fast spin-echo pulse sequence. J Magn Reson Imaging 1996 Jan-Feb;6(1):223-5

Du YP, Parker DL, Davis WL, Cao G, Buswell HR, Goodrich KC, Experimental and theoretical studies of vessel contrast-to-noise ratio in intracranial time-of-flight MR angiography. J Magn Reson Imaging 1996 Jan-Feb;6(1):99-108

Parker DL, Parker DJ, Blatter DD, Du YP, Goodrich KC, The effect of image resolution on vessel signal in high-resolution magnetic resonance angiography. J Magn Reson Imaging 1996 Jul-Aug;6(4):632-41

Allen RW, Harnsberger HR, Shelton C, King B, Bell DA, Miller R, Parkin JL, Apfelbaum RI, Parker , Low-cost high-resolution fast spin-echo MR of acoustic schwannoma: an alternative to enhanced conventional spin-echo MR? AJNR Am J Neuroradiol 1996 Aug;17(7):1205-10

Goodrich KC, Blatter DD, Parker DL, Du YP, Meyer KJ, Bernstein MA, A quantitative study of ramped radio frequency, magnetization transfer, and slab thickness in three-dimensional time-of-flight magnetic resonance angiography in a patient population. Invest Radiol 1996 Jun;31(6):323-32

Zhang J, Parker DL, Leypoldt JK, Flow distributions in hollow fiber hemodialyzers using magnetic resonance Fourier velocity imaging. ASAIO J 1995 Jul-Sep;41(3):M678-82

Du YP, Parker DL, Evaluation of gradient inhomogeneity in the optimal design of gradient coils. Magn Reson Imaging 1996;14(2):201-7

Wan X, Parker DL, Lee JN, Buswell HR, Gullberg GT, Reduction of phase error ghosting artifacts in thin slice fast spin-echo imaging. Magn Reson Med 1995 Oct;34(4):632-8

Du YP, Parker DL, Davis WL, Vessel enhancement filtering in three-dimensional MR angiography. J Magn Reson Imaging 1995 May-Jun;5(3):353-9

Parker DL, Buswell HR, Goodrich KC, Alexander AL, Keck N, Tsuruda JS, The application of magnetization transfer to MR angiography with reduced total power. Magn Reson Med 1995 Aug;34(2):283-6

Cao G, Parker DL, Sherrill DS, Du YP, Abbreviated moment-compensated phase encoding. Magn Reson Med 1995 Aug;34(2):179-85

Tang C, Blatter DD, Parker DL, Correction of partial-volume effects in phase-contrast flow measurements. J Magn Reson Imaging 1995 Mar-Apr;5(2):175-80

Du YP, Parker DL, Davis WL, Vessel enhancement filtering in three-dimensional MR angiography. J Magn Reson Imaging 1995 Mar-Apr;5(2):151-7

Parker DL, Du YP, Davis WL, The voxel sensitivity function in Fourier transform imaging: applications to magnetic resonance angiography. Magn Reson Med 1995 Feb;33(2):156-62

Ma X, Gullberg GT, Parker DL, Magnetic resonance imaging verification of a multi-compartment perfusion model for a chromatography gel phantom. Magn Reson Imaging 1995;13(4):581-98

Du YP, Parker DL, Davis WL, Cao G, Reduction of partial-volume artifacts with zero-filled interpolation in three-dimensional MR angiography. J Magn Reson Imaging 1994 Sep-Oct;4(5):733-41

Robison RO, Blatter DD, Parker DL, Barney WW, Perry DM, Goodrich KC, Reduction of slab boundary artifact with multiple overlapping thin slab acquisition in MR angiography of the cervical carotid artery. J Magn Reson Imaging 1994 Jul-Aug;4(4):529-35

Davis WL, Blatter DD, Harnsberger HR, Parker DL, Intracranial MR angiography: comparison of single-volume three-dimensional time-of-flight and multiple overlapping thin slab acquisition techniques. AJR Am J Roentgenol 1994 Oct;163(4):915-20

Zhou R, Hammond EH, Sause WT, Rubin P, Emami B, Pilepich MV, Asbell SD, Parker DL, Quantitation of prostate-specific acid phosphatase in prostate cancer: reproducibility and correlation with subjective grade. Mod Pathol 1994 May;7(4):440-8

Du Y, Parker DL, Davis WL, Blatter DD, Contrast-to-noise-ratio measurements in three-dimensional magnetic resonance angiography. Invest Radiol 1993 Nov;28(11):1004-9

Zhang Q, Parker DL, Wu J, Optical lumen measurement of coronary artery latex casts. Med Phys 1993 Mar-Apr;20(2 Pt 1):463-8

Tang C, Blatter DD, Parker DL, Accuracy of phase-contrast flow measurements in the presence of partial-volume effects. J Magn Reson Imaging 1993 Mar-Apr;3(2):377-85

Davis WL, Warnock SH, Harnsberger HR, Parker DL, Chen CX, Intracranial MRA: single volume vs. multiple thin slab 3D time-of-flight acquisition. J Comput Assist Tomogr 1993 Jan-Feb;17(1):15-21

Robison RO, Blatter DD, Parker DL, Hou P, Collins JS, Barney WW, Fat suppression in combination with multiple overlapping thin-slab 3-D acquisition MR angiography: proposed technique for improved vessel visualization. AJNR Am J Neuroradiol 1992 Sep-Oct;13(5):1429-34

Lee JN, Parker DL, MR angiography with adiabatic flow excitation. J Magn Reson Imaging 1992 Jul-Aug;2(4):431-6

Zhou R, Parker DL, Hammond EH, Quantitative peroxidase-antiperoxidase complex-substrate mass determination in tissue sections by a dual wavelength method. Anal Quant Cytol Histol 1992 Apr;14(2):73-80

Hou P, Parker DL, Blatter DD, Robison RO, Hybrid MR angiography and Fourier velocity imaging using two echo 3D acquisition. Magn Reson Med 1991 May;19(1):203-8

Parker DL, Yuan C, Blatter DD, MR angiography by multiple thin slab 3D acquisition. Magn Reson Med 1991 Feb;17(2):434-51

Gullberg GT, Ma X, Parker DL, Roy DN, An MRI perfusion model incorporating nonequilibrium exchange between vascular and extravascular compartments. Magn Reson Imaging 1991;9(1):39-52

Parker DL, Gullberg GT, Signal-to-noise efficiency in magnetic resonance imaging. Med Phys 1990 Mar-Apr;17(2):250-7

Parker DL, Caputo GR, Frederick PR, Efficient biphasic spin-echo magnetic resonance imaging. Magn Reson Med 1989 Jul;11(1):98-113

Yuan C, Gullberg GT, Parker DL, Flow-induced phase effects and compensation technique for slice-selective pulses. Magn Reson Med 1989 Feb;9(2):161-76

Yuan C, Gullberg GT, Parker DL, The solution of Bloch equations for flowing spins during a selective pulse using a finite difference method. Med Phys 1987 Nov-Dec;14(6):914-21