Polymer and Lipid Based Drug Delivery Systems, Medical Devices, HIV/AIDS, Microbicides, Cancer, siRNA

It has been reported that over 32 million adults and children globally are living with HIV/AIDS with approximately 2 million deaths occurring each year. Three-quarters of these deaths occurred in third world countries where access to drugs and other treatment modalities are expensive.

Our research group is interested in developing novel inexpensive drug delivery systems for the prevention and treatment of HIV/AIDS. We hope our delivery systems can increase user adherence, reduce sterility concerns, and most importantly reduce HIV-1 infection – factors which are significant to developed countries but even more so for third world countries.

Lim Soo P, Cho J, Grant J, Ho E, Piquette-Miller M, Allen C, Drug release mechanism of paclitaxel from a chitosan-lipid implant system: effect of swelling, degradation and morphology. Eur J Pharm Biopharm 2008 May;69(1):149-57

Ho EA, Piquette-Miller M, KLF6 and HSF4 transcriptionally regulate multidrug resistance transporters during inflammation. Biochem Biophys Res Commun 2007 Feb 16;353(3):679-85

Ho EA, Soo PL, Allen C, Piquette-Miller M, Impact of intraperitoneal, sustained delivery of paclitaxel on the expression of P-glycoprotein in ovarian tumors. J Control Release 2007 Jan 22;117(1):20-7

Yanze MF, Ho EA, Macgregor RB, Piquette-Miller M, In vivo disposition and stability of DNA frayed wires in mice. Int J Biol Macromol 2006 Nov 15;39(4-5):310-6

Ho EA, Piquette-Miller M, Regulation of multidrug resistance by pro-inflammatory cytokines. Curr Cancer Drug Targets 2006 Jun;6(4):295-311

Ho EA, Vassileva V, Allen C, Piquette-Miller M, In vitro and in vivo characterization of a novel biocompatible polymer-lipid implant system for the sustained delivery of paclitaxel. J Control Release 2005 May 5;104(1):181-91