Selected Publications

Xu X, Yang G, Zhang H, Prestwich GD, Evaluating dual activity LPA receptor pan-antagonist/autotaxin inhibitors as anti-cancer agents in vivo using engineered human tumors. Prostaglandins Other Lipid Mediat 2009 Sep;89(3-4):140-6

Zhang H, Xu X, Gajewiak J, Tsukahara R, Fujiwara Y, Liu J, Fells JI, Perygin D, Parrill AL, Tigyi G, Prestwich GD, Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res 2009 Jul 1;69(13):5441-9

Zhang H, Thompson J, Prestwich GD, A scalable synthesis of the IP7 isomer, 5-PP-Ins(1,2,3,4,6)P5. Org Lett 2009 Apr 2;11(7):1551-4

Vanderhooft JL, Alcoutlabi M, Magda JJ, Prestwich GD, Rheological properties of cross-linked hyaluronan-gelatin hydrogels for tissue engineering. Macromol Biosci 2009 Jan 9;9(1):20-8

Zhang J, Skardal A, Prestwich GD, Engineered extracellular matrices with cleavable crosslinkers for cell expansion and easy cell recovery. Biomaterials 2008 Dec;29(34):4521-31

Prestwich GD, Gajewiak J, Zhang H, Xu X, Yang G, Serban M, Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer. Biochim Biophys Acta 2008 Sep;1781(9):588-94

Serban MA, Scott A, Prestwich GD, Use of hyaluronan-derived hydrogels for three-dimensional cell culture and tumor xenografts. Curr Protoc Cell Biol 2008 Sep;Chapter 10():Unit 10.14

Prestwich GD, Kuo JW, Chemically-modified HA for therapy and regenerative medicine. Curr Pharm Biotechnol 2008 Aug;9(4):242-5

Scaife CL, Shea JE, Dai Q, Firpo MA, Prestwich GD, Mulvihill SJ, Synthetic extracellular matrix enhances tumor growth and metastasis in an orthotopic mouse model of pancreatic adenocarcinoma. J Gastrointest Surg 2008 Jun;12(6):1074-80

Serban MA, Prestwich GD, Modular extracellular matrices: solutions for the puzzle. Methods 2008 May;45(1):93-8

Serban MA, Yang G, Prestwich GD, Synthesis, characterization and chondroprotective properties of a hyaluronan thioethyl ether derivative. Biomaterials 2008 Apr;29(10):1388-99

Liu Y, Skardal A, Shu XZ, Prestwich GD, Prevention of peritendinous adhesions using a hyaluronan-derived hydrogel film following partial-thickness flexor tendon injury. J Orthop Res 2008 Apr;26(4):562-9

Gajewiak J, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD, Synthesis, pharmacology, and cell biology of sn-2-aminooxy analogues of lysophosphatidic acid. Org Lett 2008 Mar 20;10(6):1111-4

Serban MA, Liu Y, Prestwich GD, Effects of extracellular matrix analogues on primary human fibroblast behavior. Acta Biomater 2008 Jan;4(1):67-75

Prestwich GD, Evaluating drug efficacy and toxicology in three dimensions: using synthetic extracellular matrices in drug discovery. Acc Chem Res 2008 Jan;41(1):139-48

Zhang H, Xu Y, Markadieu N, Beauwens R, Erneux C, Prestwich GD, Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate. Bioorg Med Chem Lett 2008 Jan 15;18(2):762-6

Prestwich GD, Engineering a clinically-useful matrix for cell therapy. Organogenesis 2008 Jan;4(1):42-7

Gajewiak J, Tsukahara R, Tsukahara T, Fujiwara Y, Yu S, Lu Y, Murph M, Mills GB, Tigyi G, Prestwich GD, Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor. ChemMedChem 2007 Dec;2(12):1789-98

Vanderhooft JL, Mann BK, Prestwich GD, Synthesis and characterization of novel thiol-reactive poly(ethylene glycol) cross-linkers for extracellular-matrix-mimetic biomaterials. Biomacromolecules 2007 Sep;8(9):2883-9

Zhang L, Huang W, Tanimura A, Morita T, Harihar S, Dewald DB, Prestwich GD, Synthesis and biological activity of metabolically stabilized cyclopentyl trisphosphate analogues of D-myo-Ins(1,4,5)P3. ChemMedChem 2007 Sep;2(9):1281-9

Serban MA, Prestwich GD, Synthesis of hyaluronan haloacetates and biology of novel cross-linker-free synthetic extracellular matrix hydrogels. Biomacromolecules 2007 Sep;8(9):2821-8

Prestwich GD, Simplifying the extracellular matrix for 3-D cell culture and tissue engineering: a pragmatic approach. J Cell Biochem 2007 Aug 15;101(6):1370-83

Liu Y, Shu XZ, Prestwich G , Reply: A statistical correction is in order. Fertil Steril 2007 Aug 4;():

Orlandi RR, Shu XZ, McGill L, Petersen E, Prestwich GD, Structural variations in a single hyaluronan derivative significantly alter wound-healing effects in the rabbit maxillary sinus. Laryngoscope 2007 Jul;117(7):1288-95

Connors RC, Muir JJ, Liu Y, Reiss GR, Kouretas PC, Whitten MG, Sorenson TK, Prestwich GD, Bull DA, Postoperative pericardial adhesion prevention using Carbylan-SX in a rabbit model. J Surg Res 2007 Jun 15;140(2):237-42

Liu Y, Shu XZ, Prestwich GD, Tumor engineering: orthotopic cancer models in mice using cell-loaded, injectable, cross-linked hyaluronan-derived hydrogels. Tissue Eng 2007 May;13(5):1091-101

Huang W, Zhang H, Davrazou F, Kutateladze TG, Shi X, Gozani O, Prestwich GD, Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. J Am Chem Soc 2007 May 23;129(20):6498-506

Jiang G, Xu Y, Fujiwara Y, Tsukahara T, Tsukahara R, Gajewiak J, Tigyi G, Prestwich GD, Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA. ChemMedChem 2007 May;2(5):679-90

Liu Y, Shu XZ, Prestwich GD, Reduced postoperative intra-abdominal adhesions using Carbylan-SX, a semisynthetic glycosaminoglycan hydrogel. Fertil Steril 2007 Apr;87(4):940-8

Liu Y, Cai S, Shu XZ, Shelby J, Prestwich GD, Release of basic fibroblast growth factor from a crosslinked glycosaminoglycan hydrogel promotes wound healing. Wound Repair Regen 2007 Mar-Apr;15(2):245-51

Prestwich GD, Liu Y, Yu B, Shu XZ, Scott A, 3-D culture in synthetic extracellular matrices: new tissue models for drug toxicology and cancer drug discovery. Adv Enzyme Regul 2007;47():196-207

Park AH, Hughes CW, Jackson A, Hunter L, McGill L, Simonsen SE, Alder SC, Shu XZ, Prestwich GD, Crosslinked hydrogels for tympanic membrane repair. Otolaryngol Head Neck Surg 2006 Dec;135(6):877-83

Shu XZ, Ahmad S, Liu Y, Prestwich GD, Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering. J Biomed Mater Res A 2006 Dec 15;79(4):902-12

Zhang H, Markadieu N, Beauwens R, Erneux C, Prestwich GD, Synthesis and biological activity of PTEN-resistant analogues of phosphatidylinositol 3,4,5-trisphosphate. J Am Chem Soc 2006 Dec 27;128(51):16464-5

Liu Y, Shu XZ, Prestwich GD, Osteochondral defect repair with autologous bone marrow-derived mesenchymal stem cells in an injectable, in situ, cross-linked synthetic extracellular matrix. Tissue Eng 2006 Dec;12(12):3405-16

Liu Y, Shu XZ, Prestwich G , Osteochondral Defect Repair with Autologous Bone Marrow-Derived Mesenchymal Stem Cells in an Injectable, In Situ, Cross-Linked Synthetic Extracellular Matrix. Tissue Eng 2006 Oct 1;():

Xu Y, Jiang G, Tsukahara R, Fujiwara Y, Tigyi G, Prestwich GD, Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors. J Med Chem 2006 Aug 24;49(17):5309-15

Zhang H, Tsukuhara R, Tigyi G, Prestwich GD, Synthesis of cyclic phosphonate analogues of (lyso)phosphatidic acid using a ring-closing metathesis reaction. J Org Chem 2006 Aug 4;71(16):6061-6

Sondrup C, Liu Y, Shu XZ, Prestwich GD, Smith ME, Cross-linked hyaluronan-coated stents in the prevention of airway stenosis. Otolaryngol Head Neck Surg 2006 Jul;135(1):28-35

Liu Y, Ahmad S, Shu XZ, Sanders RK, Kopesec SA, Prestwich GD, Accelerated repair of cortical bone defects using a synthetic extracellular matrix to deliver human demineralized bone matrix. J Orthop Res 2006 Jul;24(7):1454-62

Gajewiak J, Xu Y, Lee SA, Kutateladze TG, Prestwich GD, Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphate. Org Lett 2006 Jun 22;8(13):2811-3

Gajewiak J, Cai S, Shu XZ, Prestwich GD, Aminooxy pluronics: synthesis and preparation of glycosaminoglycan adducts. Biomacromolecules 2006 Jun;7(6):1781-9

Rose TM, Prestwich GD, Synthesis and evaluation of fluorogenic substrates for phospholipase D and phospholipase C. Org Lett 2006 Jun 8;8(12):2575-8

Ferguson CG, Bigman CS, Richardson RD, van Meeteren LA, Moolenaar WH, Prestwich GD, Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity. Org Lett 2006 May 11;8(10):2023-6

Zhang H, Xu Y, Zhang Z, Liman ER, Prestwich GD, Synthesis and biological activity of phospholipase C-resistant analogues of phosphatidylinositol 4,5-bisphosphate. J Am Chem Soc 2006 May 3;128(17):5642-3

Proctor M, Proctor K, Shu XZ, McGill LD, Prestwich GD, Orlandi RR, Composition of hyaluronan affects wound healing in the rabbit maxillary sinus. Am J Rhinol 2006 Mar-Apr;20(2):206-11

Rose TM, Prestwich GD, Fluorogenic phospholipids as head group-selective reporters of phospholipase A activity. ACS Chem Biol 2006 Mar 17;1(2):83-91

Qian L, Xu Y, Simper T, Jiang G, Aoki J, Umezu-Goto M, Arai H, Yu S, Mills GB, Tsukahara R, Makarova N, Fujiwara Y, Tigyi G, Prestwich GD, Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists. ChemMedChem 2006 Mar;1(3):376-83

Zhang H, Shibuya K, Hemmi H, Nishino T, Prestwich GD, Total synthesis of geranylgeranylglyceryl phosphate enantiomers: substrates for characterization of 2,3-O-digeranylgeranylglyceryl phosphate synthase. Org Lett 2006 Mar 2;8(5):943-6

Jiang G, Xu Y, Prestwich GD, Practical enantiospecific syntheses of lysobisphosphatidic acid and its analogues. J Org Chem 2006 Feb 3;71(3):934-9

Prestwich GD, Shu XZ, Liu Y, Cai S, Walsh JF, Hughes CW, Ahmad S, Kirker KR, Yu B, Orlandi RR, Park AH, Thibeault SL, Duflo S, Smith ME, Injectable synthetic extracellular matrices for tissue engineering and repair. Adv Exp Med Biol 2006;585():125-33

Xu Y, Lee SA, Kutateladze TG, Sbrissa D, Shisheva A, Prestwich GD, Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate. J Am Chem Soc 2006 Jan 25;128(3):885-97

Prestwich GD, Xu Y, Qian L, Gajewiak J, Jiang G, New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors. Biochem Soc Trans 2005 Dec;33(Pt 6):1357-61

Brunecky R, Lee S, Rzepecki PW, Overduin M, Prestwich GD, Kutateladze AG, Kutateladze T , Investigation of the Binding Geometry of a Peripheral Membrane Protein. Biochemistry 2005 Dec 13;44(49):16064-16071

Ferguson CG, James RD, Bigman CS, Shepard DA, Abdiche Y, Katsamba PS, Myszka DG, Prestwich GD, Phosphoinositide-containing polymerized liposomes: stable membrane-mimetic vesicles for protein-lipid binding analysis. Bioconjug Chem 2005 Nov-Dec;16(6):1475-83

Cai S, Liu Y, Zheng Shu X, Prestwich GD, Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor. Biomaterials 2005 Oct;26(30):6054-67

Jiang G, Xu Y, Falguières T, Gruenberg J, Prestwich GD, Concise synthesis of ether analogues of lysobisphosphatidic acid. Org Lett 2005 Sep 1;7(18):3837-40

Prestwich GD, Visualization and perturbation of phosphoinositide and phospholipid signaling. Prostaglandins Other Lipid Mediat 2005 Sep;77(1-4):168-78

Hansen JK, Thibeault SL, Walsh JF, Shu XZ, Prestwich GD, In vivo engineering of the vocal fold extracellular matrix with injectable hyaluronic acid hydrogels: early effects on tissue repair and biomechanics in a rabbit model. Ann Otol Rhinol Laryngol 2005 Sep;114(9):662-70

Ghosh K, Shu XZ, Mou R, Lombardi J, Prestwich GD, Rafailovich MH, Clark R , Rheological Characterization of in Situ Cross-Linkable Hyaluronan Hydrogels. Biomacromolecules 2005 Sep 12;6(5):2857-2865

Liu Y, Zheng Shu X, Prestwich GD, Biocompatibility and stability of disulfide-crosslinked hyaluronan films. Biomaterials 2005 Aug;26(23):4737-46

Dewald DB, Ozaki S, Malaviya S, Shope JC, Manabe K, Crosby L, Neilsen P, Johnston D, Harihar S, Prestwich GD, Cellular calcium mobilization in response to phosphoinositide delivery. Cell Calcium 2005 Aug;38(2):59-72

Xu Y, Aoki J, Shimizu K, Umezu-Goto M, Hama K, Takanezawa Y, Yu S, Mills GB, Arai H, Qian L, Prestwich GD, Structure-activity relationships of fluorinated lysophosphatidic acid analogues. J Med Chem 2005 May 5;48(9):3319-27

Liu Y, Li H, Shu XZ, Gray SD, Prestwich GD, Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesions. Fertil Steril 2005 Apr;83 Suppl 1():1275-83

Xu Y, Tanaka M, Arai H, Aoki J, Prestwich GD, Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors. Bioorg Med Chem Lett 2004 Nov 1;14(21):5323-8

Liu Y, Webb K, Kirker KR, Bernshaw NJ, Tresco PA, Gray SD, Prestwich GD, Composite articular cartilage engineered on a chondrocyte-seeded aliphatic polyurethane sponge. Tissue Eng 2004 Jul-Aug;10(7-8):1084-92

Gilbert ME, Kirker KR, Gray SD, Ward PD, Szakacs JG, Prestwich GD, Orlandi RR, Chondroitin sulfate hydrogel and wound healing in rabbit maxillary sinus mucosa. Laryngoscope 2004 Aug;114(8):1406-9

Kirker KR, Luo Y, Morris SE, Shelby J, Prestwich GD, Glycosaminoglycan hydrogels as supplemental wound dressings for donor sites. J Burn Care Rehabil 2004 May-Jun;25(3):276-86

Prestwich GD, Phosphoinositide signaling; from affinity probes to pharmaceutical targets. Chem Biol 2004 May;11(5):619-37

Li H, Liu Y, Shu XZ, Gray SD, Prestwich GD, Synthesis and biological evaluation of a cross-linked hyaluronan-mitomycin C hydrogel. Biomacromolecules 2004 May-Jun;5(3):895-902

Liu XH, Prestwich GD, Didehydrofarnesyl diphosphate: an intrinsically fluorescent inhibitor of protein farnesyltransferase. Bioorg Med Chem Lett 2004 May 3;14(9):2137-40

Prestwich GD, Visualizing signalling by phosphoinositide 3-kinase pathway lipids. Biochem Soc Trans 2004 Apr;32(Pt 2):336-7

Liu XH, Suh DY, Call J, Prestwich GD, Antigenic prenylated peptide conjugates and polyclonal antibodies to detect protein prenylation. Bioconjug Chem 2004 Mar-Apr;15(2):270-7

Xu Y, Fang Y, Chen J, Prestwich GD, Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid. Bioorg Med Chem Lett 2004 Mar 22;14(6):1461-4

Cai S, Dufner-Beattie JL, Prestwich GD, A selective protein sensor for heparin detection. Anal Biochem 2004 Mar 1;326(1):33-41

Shu XZ, Ghosh K, Liu Y, Palumbo FS, Luo Y, Clark RA, Prestwich GD, Attachment and spreading of fibroblasts on an RGD peptide-modified injectable hyaluronan hydrogel. J Biomed Mater Res A 2004 Feb 1;68(2):365-75

Zhang H, Liu XH, Zhang K, Chen CK, Frederick JM, Prestwich GD, Baehr W, Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein. J Biol Chem 2004 Jan 2;279(1):407-13

Liu Y, Shu XZ, Gray SD, Prestwich GD, Disulfide-crosslinked hyaluronan-gelatin sponge: growth of fibrous tissue in vivo. J Biomed Mater Res A 2004 Jan 1;68(1):142-9

Zheng Shu X, Liu Y, Palumbo FS, Luo Y, Prestwich GD, In situ crosslinkable hyaluronan hydrogels for tissue engineering. Biomaterials 2004 Mar-Apr;25(7-8):1339-48

Qian L, Xu Y, Hasegawa Y, Aoki J, Mills GB, Prestwich GD, Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity. J Med Chem 2003 Dec 18;46(26):5575-8

Qian L, Xu Y, Arai H, Aoki J, McIntyre TM, Prestwich GD, Synthesis of migration-resistant hydroxyethoxy analogues of lysophosphatidic acid. Org Lett 2003 Nov 27;5(24):4685-8

Hinshaw JC, Suh DY, Garnier P, Buckner FS, Eastman RT, Matsuda SP, Joubert BM, Coppens I, Joiner KA, Merali S, Nash TE, Prestwich GD, Oxidosqualene cyclase inhibitors as antimicrobial agents. J Med Chem 2003 Sep 25;46(20):4240-3

Shu XZ, Liu Y, Palumbo F, Prestwich GD, Disulfide-crosslinked hyaluronan-gelatin hydrogel films: a covalent mimic of the extracellular matrix for in vitro cell growth. Biomaterials 2003 Sep;24(21):3825-34

Xu Y, Qian L, Prestwich GD, Synthesis of monofluorinated analogues of lysophosphatidic acid. J Org Chem 2003 Jun 27;68(13):5320-30

Xu Y, Qian L, Prestwich GD, Synthesis of alpha-fluorinated phosphonates from alpha-fluorovinylphosphonates: a new route to analogues of lysophosphatidic acid. Org Lett 2003 Jun 26;5(13):2267-70

Ward DM, Shiflett SL, Huynh D, Vaughn MB, Prestwich G, Kaplan , Use of expression constructs to dissect the functional domains of the CHS/beige protein: identification of multiple phenotypes. Traffic 2003 Jun;4(6):403-15

McIntyre TM, Pontsler AV, Silva AR, St Hilaire A, Xu Y, Hinshaw JC, Zimmerman GA, Hama K, Aoki J, Arai H, Prestwich GD, Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc Natl Acad Sci U S A 2003 Jan 7;100(1):131-6

Shu XZ, Liu Y, Luo Y, Roberts MC, Prestwich GD, Disulfide cross-linked hyaluronan hydrogels. Biomacromolecules 2002 Nov-Dec;3(6):1304-11

Xu Y, Prestwich GD, Synthesis of chiral (alpha,alpha-difluoroalkyl)phosphonate analogues of (lyso)phosphatidic acid via hydrolytic kinetic resolution. Org Lett 2002 Nov 14;4(23):4021-4

Xu Y, Prestwich GD, Concise synthesis of acyl migration-blocked 1,1-difluorinated analogues of lysophosphatidic acid. J Org Chem 2002 Oct 4;67(20):7158-61

Lazar J, Greenwood DR, Rasmussen LE, Prestwich GD, Molecular and functional characterization of an odorant binding protein of the Asian elephant, Elephas maximus: implications for the role of lipocalins in mammalian olfaction. Biochemistry 2002 Oct 1;41(39):11786-94

Kirker KR, Luo Y, Nielson JH, Shelby J, Prestwich GD, Glycosaminoglycan hydrogel films as bio-interactive dressings for wound healing. Biomaterials 2002 Sep;23(17):3661-71

Rzepecki PW, Prestwich GD, Synthesis of hybrid lipid probes: derivatives of phosphatidylethanolamine-extended phosphatidylinositol 4,5-bisphosphate (Pea-PIP(2)). J Org Chem 2002 Aug 9;67(16):5454-60

Vercruysse KP, Li H, Luo Y, Prestwich GD, Thermosensitive lanthanide complexes of hyaluronan. Biomacromolecules 2002 Jul-Aug;3(4):639-43

Prestwich GD, Matthew H, Hybrid, composite, and complex biomaterials. Ann N Y Acad Sci 2002 Jun;961():106-8

Chen R, Kang VH, Chen J, Shope JC, Torabinejad J, DeWald DB, Prestwich GD, A monoclonal antibody to visualize PtdIns(3,4,5)P(3) in cells. J Histochem Cytochem 2002 May;50(5):697-708

Luo Y, Bernshaw NJ, Lu ZR, Kopecek J, Prestwich GD, Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates. Pharm Res 2002 Apr;19(4):396-402

Rapoport N, Marin A, Luo Y, Prestwich GD, Muniruzzaman MD, Intracellular uptake and trafficking of Pluronic micelles in drug-sensitive and MDR cells: effect on the intracellular drug localization. J Pharm Sci 2002 Jan;91(1):157-70

Liu XH, Prestwich GD, Didehydrogeranylgeranyl (Delta Delta GG): a fluorescent probe for protein prenylation. J Am Chem Soc 2002 Jan 9;124(1):20-1

Prestwich GD, Chen R, Feng L, Ozaki S, Ferguson CG, Drees BE, Neklason DA, Mostert MJ, Porter-Gill PA, Kang VH, Shope JC, Neilsen PO, Dewald DB, In situ detection of phospholipid and phosphoinositide metabolism. Adv Enzyme Regul 2002;42():19-38

Luo Y, Prestwich GD, Hyaluronic acid-N-hydroxysuccinimide: a useful intermediate for bioconjugation. Bioconjug Chem 2001 Nov-Dec;12(6):1085-8

DeWald DB, Torabinejad J, Jones CA, Shope JC, Cangelosi AR, Thompson JE, Prestwich GD, Hama H, Rapid accumulation of phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate correlates with calcium mobilization in salt-stressed arabidopsis. Plant Physiol 2001 Jun;126(2):759-69

Davies SS, Pontsler AV, Marathe GK, Harrison KA, Murphy RC, Hinshaw JC, Prestwich GD, Hilaire AS, Prescott SM, Zimmerman GA, McIntyre TM, Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. J Biol Chem 2001 May 11;276(19):16015-23

Feng L, Mejillano M, Yin HL, Chen J, Prestwich GD, Full-contact domain labeling: identification of a novel phosphoinositide binding site on gelsolin that requires the complete protein. Biochemistry 2001 Jan 30;40(4):904-13

Liu XH, Wang HK, Herron JN, Prestwich GD, Photopatterning of antibodies on biosensors. Bioconjug Chem 2000 Nov-Dec;11(6):755-61

Luo Y, Kirker KR, Prestwich GD, Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J Control Release 2000 Oct 3;69(1):169-84

Ozaki S, DeWald DB, Shope JC, Chen J, Prestwich GD, Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers. Proc Natl Acad Sci U S A 2000 Oct 10;97(21):11286-91

Dang T, Prestwich GD, Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution. Chem Biol 2000 Aug;7(8):643-9

Mehrotra B, Myszka DG, Prestwich GD, Binding kinetics and ligand specificity for the interactions of the C2B domain of synaptogmin II with inositol polyphosphates and phosphoinositides. Biochemistry 2000 Aug 15;39(32):9679-86

Peng J, Chen PY, Marchase RB, Prestwich GD, Preparation and use of a photoactivatable glucose-6-phosphate analogue. Bioorg Med Chem Lett 2000 Mar 20;10(6):535-9

Luo Y, Ziebell MR, Prestwich GD, A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells. Biomacromolecules 2000 Summer;1(2):208-18

Luo Y, Prestwich GD, Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate. Bioconjug Chem 1999 Sep-Oct;10(5):755-63

Ganem B, Dong Y, Zheng YF, Prestwich GD, Amidrazone and Amidoxime Inhibitors of Squalene Hopene Cyclase. J Org Chem 1999 Jul 23;64(15):5441-5446

Dang T, Abe I, Zheng YF, Prestwich GD, The binding site for an inhibitor of squalene:hopene cyclase determined using photoaffinity labeling and molecular modeling. Chem Biol 1999 Jun;6(6):333-41

Vercruysse KP, Ziebell MR, Prestwich GD, Control of enzymatic degradation of hyaluronan by divalent cations. Carbohydr Res 1999 May 31;318(1-4):26-37

Abe I, Zheng YF, Prestwich GD, Mechanism-based inhibitors and other active-site targeted inhibitors of oxidosqualene cyclase and squalene cyclase. J Enzyme Inhib 1998 Sep;13(6):385-98

Prestwich GD, Marecak DM, Marecek JF, Vercruysse KP, Ziebell MR, Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives. J Control Release 1998 Apr 30;53(1-3):93-103

Zheng YF, Abe I, Prestwich GD, Inhibition kinetics and affinity labeling of bacterial squalene:hopene cyclase by thia-substituted analogues of 2, 3-oxidosqualene. Biochemistry 1998 Apr 28;37(17):5981-7

Abe I, Zheng YF, Prestwich GD, Photoaffinity labeling of oxidosqualene cyclase and squalene cyclase by a benzophenone-containing inhibitor. Biochemistry 1998 Apr 28;37(17):5779-84

Chaudhary A, Gu QM, Thum O, Profit AA, Qi Y, Jeyakumar L, Fleischer S, Prestwich GD, Specific interaction of Golgi coatomer protein alpha-COP with phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998 Apr 3;273(14):8344-50

Chen J, Prestwich GD, Asymmetric Synthesis of Water-Soluble, Nonhydrolyzable Phosphonate Analogue of Phosphatidylinositol 4,5-Bisphosphate. J Org Chem 1998 Feb 6;63(3):430-431

Vercruysse KP, Prestwich GD, Hyaluronate derivatives in drug delivery. Crit Rev Ther Drug Carrier Syst 1998;15(5):513-55

Vercruysse KP, Marecak DM, Marecek JF, Prestwich GD, Synthesis and in vitro degradation of new polyvalent hydrazide cross-linked hydrogels of hyaluronic acid. Bioconjug Chem 1997 Sep-Oct;8(5):686-94

Prestwich GD, Dormán G, Elliott JT, Marecak DM, Chaudhary A, Benzophenone photoprobes for phosphoinositides, peptides and drugs. Photochem Photobiol 1997 Feb;65(2):222-34

Mayer MP, Prestwich GD, Dolence JM, Bond PD, Wu HY, Poulter CD, Protein farnesyltransferase: production in Escherichia coli and immunoaffinity purification of the heterodimer from Saccharomyces cerevisiae. Gene 1993 Sep 30;132(1):41-7