Personal Profile
James W. Wiskin
Adjunct Associate Professor, Bioengineering
Senior Scientist, Co-founder, TechniScan, Inc.
Senior Scientist, CVUS clinical trials, LLC
_______________________________________
CVUS clinical trials awarded $3.2 million NCI grant - Sept. 2012
TechniScan awarded $2.8 million dollar Grant -National Institutes of Health - 2006
TechniScan gets $9 million dollar equity investment and OEM agreement - 2005
Ph.D. Mathematics, University of Utah, 1991
(Inverse Scattering, Scientific Computation, Differential Geometry in Wave Propagation)
M.Sc. Bio-Mathematics, Dalhousie University,
B. Math. Pure and Applied Mathematics, University of Waterloo, Waterloo
E-mail:
Phone: 801 484 6907
Office: CVUS clinical trials, Inc. 3216 Highland Dr., Salt Lake City, UT, 84106
Office: CVUS clinical trials, Inc. 3216 Highland Dr., Salt Lake City, UT, 84106
Lab
Advanced Imaging Methods Laboratory
Research
Inverse Scattering , Medical Imaging, Electromagnetics, Acoustics, wave propagation
Current Research
Please see http://www.bioen.utah.edu/faculty/Wiskin/
Dr. Wiskin is a co-founder, and co-inventor of the fundamental imaging algorithms used by TechniScan. His research includes the theory of inverse scattering, optimization, image processing, and acoustic, electromagnetic, and elastic wave propagation. His dissertation at the University of Utah (Mathematics) established new inverse scattering imaging methods. Dr. Wiskin has taught upper division courses in mathematics and electrical engineering at the University of Utah in optimization theory, nonlinear systems of differential equations, engineering mathematics and wave propagation. Presently he is focused on the Breast Cancer Imaging problem through inverse scattering, at CVUS, LLC. (see above links)
PATENTS:
“Apparatus and method for imaging objects with wavefields”, 7,841,982
“Breast Scanning System,”. 7,771,360, Inventors: SA, Johnson, M. Berggren, J. W. Wiskin.,et al. USA Patent, Aug. 10, 2010.
“Method for imaging and treating a breast,”. 7,699,783, Inventors: B. K. Hanover, Johnson, S. A., D. Robinson, J. W. Wiskin., et al. USA Patent, Apr. 20, 2010.
“Apparatus and Method for Imaging Objects with Wavefields,”. 7,684,846, Inventors: Steven A. Johnson, D. T. Borup, J. W. Wiskin., USA Patent, Mar. 23, 2010.
“Apparatus and Method for Imaging Objects with Wavefields,”, Aug. 4, 2009, 7,570,742, Inventors: Steven A. Johnson, D. T. Borup, J. W. Wiskin.
“Apparatus and Method for Imaging Objects with Wavefields,” 6,636,584, Inventors: Steven A. Johnson, D. T. Borup, J. W. Wiskin, and M. Berggren. USA Patent, Oct. 21, 2003.
“Apparatus and Method for Imaging Objects with Wavefields,” 6,587,540, Inventors: Steven A. Johnson, D. T. Borup, J. W. Wiskin, and M. Berggren., USA Patent, July 1, 2003.
Apparatus and method for imaging using inverse scattering techniques and Wave-field Energy", 6,005,916, Inventors: Steven A. Johnson, James W. Wiskin, David T. Borup, F. Natterer, F. Weubbeling, USA, PatentDec. 21, 1999
"Wave Imaging Using Inverse Scattering Techniques", Inventors: Steven A. Johnson, James W. Wiskin, David T. Borup, Frank Stenger, D. A. Christensen, USA Patent 5,588,032, Dec. 24, 1996
PAST STUDENTS:
1. Chris Dawn Correa -- M.Sc. in Dept. Chemical and Fuels Engineering, U. of Utah, March, 1998
2. Jay Ostler -- M.Sc. in Mechanical Engineering, U. of Utah, Fall 1998
3. Jesse Shelke -- Ph.D. in Mechanical Engineering, U. of Utah, Fall 2000
4. Shay Shoham -- Ph.D. in Bioengineering, U of Utah, 2001
5. Kungf-shan Sheng -- Ph.D. Mechanical Engineering, U. of Utah, expected Dec. 2004
6. Chris Butson – Ph.D. Bioengineering, U. of Utah, 2004
7. Apinya Lertratanakul – M.Sc. 2001
Recent Publications/Presentations:
Wiskin, J., Borup, D., Andre, M., Johnson, S. A., Greenleaf, J., Parisky, Y., Klock, J., “Nonlinear inverse scattering in 3D: quantitative transmission algorithms, refraction corrected reflection, scanner design and clinical results”, Invited Lecture/paper, International Congress on Acoustics (ICA), Acoustical Society of America, Canadian Acoustical Association, joint meeting, June 2-7, 2013.
Andre, J Wiskin, D Borup, “Clinical Results with Ultrasound Computed Tomography of the Breast“,chapter 15, Quantitative Ultrasound in Soft Tissue, J. Mamou and M. L. Oelze, Springer, 2013.
J. Wiskin, D. Borup, S. Johnson, M. Berggren, Non-linear inverse scattering: High resolution quantitative breast tissue tomography, J. Acoust. Soc. Am. 131, 3802 (2012); http://dx.doi.org/10.1121/1.3699240, (also in Vir. J. Bio. Phys. Res., Vol. 23, (10), Instrumentation and Development)
J. Wiskin, D. Borup, S. Johnson, "Inverse scattering: Theory," Acoustical Imaging 30, pp. 53-59, Springer, Dordrecht, 2011.
J. Wiskin, D. Borup, K. Callahan, Y. Parisky, J. Smith, M. André, S. Johnson, "Inverse scattering Results," Acoustical Imaging 30, pp. 61-68, Springer, Dordrecht, 2011.
J. Wiskin; D. Borup; S. Johnson; M. Berggren; D. Robinson; J. Smith; J. Chen; Y. Parisky; John Klock, ‘Inverse scattering and refraction corrected reflection for breast cancer imaging’, Jan D'hooge; Stephen A. McAleavey, Eds., Proc. SPIE, Medical Imaging Conference, San Diego, Feb. 12-15,2010, 7629, 2010
Wiskin et al., 'QUANTITATIVE ULTRASOUND INVERSE SCATTERING, AND TOMOGRAPHIC REFRACTION CORRECTED B-SCAN', American Institute of Ultrasound in Medicine (AIUM) meeting, in San Diego, March 26,27 2010
Borup, D., Wiskin, JW, et al. '360 DEGREE COMPOUNDED, REFRACTION CORRECTED REFLECTION IMAGES OF HUMAN BREAST',American Institute of Ultrasound in Medicine (AIUM) meeting, in San Diego, March 26,27 2010
M.P. Andre, C Barker, N Sekhon, J Wiskin, D Borup, K. Callahan: Pre-clinical experience with full-wave inverse scattering for breast imaging: Sound speed sensitivity, Acoustical Imaging 29:73-80, Springer, Dordrecht, 2009.
MP Andre, C Barker, N Sekhon, J Wiskin, D Borup, K. Callahan: Pre-clinical experience with full-wave inverse scattering for breast imaging: Sound speed sensitivity, Acoustical Imaging 29:73-80, 2008.
Wiskin, J., 3-D Imaging Molecular Diagnostics: Inverse Scattering Algorithms, James Wiskin, Ph.D., Invited talk at the AACC sponsored 40th Annual Oak Ridge Conference - Breakthrough Technologies for Clinical Diagnostics , The Fairmont, San José, CA., American Assoc. of Clinical Chemists, San Jose California, April 17 - 18, 2008.
Wiskin, J. D. T. Borup, S.A. Johnson, M. Berggren, T. Abbott, R. Hanover, “Full-Wave, Non-linear, Inverse Scattering,” Acoustical Imaging, Vol. 28, p183-193,. M. Andre, editor, Springer, 2007
Johnson,S. T. Abbott, R. Bell, M Berggren, D. Borup, D. Robinson, J. Wiskin, S. Olsen, B. Hanover, “Non-Invasive Breast Tissue Characterization Using Ultrasound Speed and Attenuation,” , Acoustical Imaging, Vol. 28, p147-154, M. Andre, editor, Springer, 2007
Callahan, KS, DT Borup, SA Johnson, J Wiskin, Y Parisky, Transmission breast ultrasound Imaging representative case studies of speed of sound and attenuation of sound computed tomographic Images., 17th Annual National Interdisciplinary Breast Conference, , Las Vegas, NV., 2007
Wiskin, J., D. Borup, S. Johnson, M. Berggren, B. Hanover, S. Olsen, F. Setinsek, R. Hanover, and TSI staff, Full wave nonlinear inverse scattering for transmission breast imaging, 4th JOINT MEETING OF THE ACOUSTICAL SOCIETY OF AMERICA AND THE ACOUSTICAL SOCIETY OF JAPAN 28, Special session on: BIOMEDICAL ULTRASOUND/BIORESPONSE TO VIBRATION: (BB), Acoustic tomography in tissue., Nov. 2006
Wiskin, JW, DT Borup, SA Johnson, M Berggren, T. Abbott, R. Hanover, “Full Wave Nonlinear Inverse Scattering: High Resolution Quantitative Breast Tissue Tomography”, Invited Talk at the 28th Acoustical Imaging Symposium in San Diego, California, March 20-23, 2005.
Johnson, SA, R. Hanover, DT Borup, JW Wiskin, M Berggren, M Kammeyer, Scott Olsen, Jeff Pattee, F. Setinsek, K. Stewart, B. Hanover, “Design and first Clinical Implementation of the Ultrasound CT™ System for Breast Imaging”, Acoustical Imaging 28 Symposium in San Diego, California, March 20-23, 2005.
Johnson, SA, R. Hanover, DT Borup, JW Wiskin, M. Berggren, “Noninvasive Breast Tissue Characterization Using Ultrasound Speed and Attenuation: In Vivo Validation”, Acoustical Imaging 28 Symposium in San Diego, California, March 20-23, 2005
Kung-Shan Cheng, James W. Wiskin and Robert B. Roemer, “Advanced Fourier Marching Method for SAR Calculations in Thermal Therapies”, submitted to Hyperthermia, 2005
Wiskin, JW, Johnson, SA, Borup, DT., “Wave Propagation and Nonlinear Inversion in Layered or Moving Media - Fast Algorithms for High Contrasts,”, Soc. Indust. Appl. Math. Annual Meeting, Proceedings, San Diego, California, July 9-13, 2001.
Johnson, S. A., D. T. Borup, J W. Wiskin, M. J. Berggren, T. Guillerm, and S C. Olsen, “Fast, non-perturbative, transmission inverse scattering, quantitative imaging with laboratory and simulated acoustic data”, Invited lecture at 139th Meeting of the Acoustical Society of America, May, 2000.
Dr. Wiskin is a co-founder, and co-inventor of the fundamental imaging algorithms used by TechniScan. His research includes the theory of inverse scattering, optimization, image processing, and acoustic, electromagnetic, and elastic wave propagation. His dissertation at the University of Utah (Mathematics) established new inverse scattering imaging methods. Dr. Wiskin has taught upper division courses in mathematics and electrical engineering at the University of Utah in optimization theory, nonlinear systems of differential equations, engineering mathematics and wave propagation. Presently he is focused on the Breast Cancer Imaging problem through inverse scattering, at CVUS, LLC. (see above links)
PATENTS:
“Apparatus and method for imaging objects with wavefields”, 7,841,982
“Breast Scanning System,”. 7,771,360, Inventors: SA, Johnson, M. Berggren, J. W. Wiskin.,et al. USA Patent, Aug. 10, 2010.
“Method for imaging and treating a breast,”. 7,699,783, Inventors: B. K. Hanover, Johnson, S. A., D. Robinson, J. W. Wiskin., et al. USA Patent, Apr. 20, 2010.
“Apparatus and Method for Imaging Objects with Wavefields,”. 7,684,846, Inventors: Steven A. Johnson, D. T. Borup, J. W. Wiskin., USA Patent, Mar. 23, 2010.
“Apparatus and Method for Imaging Objects with Wavefields,”, Aug. 4, 2009, 7,570,742, Inventors: Steven A. Johnson, D. T. Borup, J. W. Wiskin.
“Apparatus and Method for Imaging Objects with Wavefields,” 6,636,584, Inventors: Steven A. Johnson, D. T. Borup, J. W. Wiskin, and M. Berggren. USA Patent, Oct. 21, 2003.
“Apparatus and Method for Imaging Objects with Wavefields,” 6,587,540, Inventors: Steven A. Johnson, D. T. Borup, J. W. Wiskin, and M. Berggren., USA Patent, July 1, 2003.
Apparatus and method for imaging using inverse scattering techniques and Wave-field Energy", 6,005,916, Inventors: Steven A. Johnson, James W. Wiskin, David T. Borup, F. Natterer, F. Weubbeling, USA, PatentDec. 21, 1999
"Wave Imaging Using Inverse Scattering Techniques", Inventors: Steven A. Johnson, James W. Wiskin, David T. Borup, Frank Stenger, D. A. Christensen, USA Patent 5,588,032, Dec. 24, 1996
PAST STUDENTS:
1. Chris Dawn Correa -- M.Sc. in Dept. Chemical and Fuels Engineering, U. of Utah, March, 1998
2. Jay Ostler -- M.Sc. in Mechanical Engineering, U. of Utah, Fall 1998
3. Jesse Shelke -- Ph.D. in Mechanical Engineering, U. of Utah, Fall 2000
4. Shay Shoham -- Ph.D. in Bioengineering, U of Utah, 2001
5. Kungf-shan Sheng -- Ph.D. Mechanical Engineering, U. of Utah, expected Dec. 2004
6. Chris Butson – Ph.D. Bioengineering, U. of Utah, 2004
7. Apinya Lertratanakul – M.Sc. 2001
Recent Publications/Presentations:
Wiskin, J., Borup, D., Andre, M., Johnson, S. A., Greenleaf, J., Parisky, Y., Klock, J., “Nonlinear inverse scattering in 3D: quantitative transmission algorithms, refraction corrected reflection, scanner design and clinical results”, Invited Lecture/paper, International Congress on Acoustics (ICA), Acoustical Society of America, Canadian Acoustical Association, joint meeting, June 2-7, 2013.
Andre, J Wiskin, D Borup, “Clinical Results with Ultrasound Computed Tomography of the Breast“,chapter 15, Quantitative Ultrasound in Soft Tissue, J. Mamou and M. L. Oelze, Springer, 2013.
J. Wiskin, D. Borup, S. Johnson, M. Berggren, Non-linear inverse scattering: High resolution quantitative breast tissue tomography, J. Acoust. Soc. Am. 131, 3802 (2012); http://dx.doi.org/10.1121/1.3699240, (also in Vir. J. Bio. Phys. Res., Vol. 23, (10), Instrumentation and Development)
J. Wiskin, D. Borup, S. Johnson, "Inverse scattering: Theory," Acoustical Imaging 30, pp. 53-59, Springer, Dordrecht, 2011.
J. Wiskin, D. Borup, K. Callahan, Y. Parisky, J. Smith, M. André, S. Johnson, "Inverse scattering Results," Acoustical Imaging 30, pp. 61-68, Springer, Dordrecht, 2011.
J. Wiskin; D. Borup; S. Johnson; M. Berggren; D. Robinson; J. Smith; J. Chen; Y. Parisky; John Klock, ‘Inverse scattering and refraction corrected reflection for breast cancer imaging’, Jan D'hooge; Stephen A. McAleavey, Eds., Proc. SPIE, Medical Imaging Conference, San Diego, Feb. 12-15,2010, 7629, 2010
Wiskin et al., 'QUANTITATIVE ULTRASOUND INVERSE SCATTERING, AND TOMOGRAPHIC REFRACTION CORRECTED B-SCAN', American Institute of Ultrasound in Medicine (AIUM) meeting, in San Diego, March 26,27 2010
Borup, D., Wiskin, JW, et al. '360 DEGREE COMPOUNDED, REFRACTION CORRECTED REFLECTION IMAGES OF HUMAN BREAST',American Institute of Ultrasound in Medicine (AIUM) meeting, in San Diego, March 26,27 2010
M.P. Andre, C Barker, N Sekhon, J Wiskin, D Borup, K. Callahan: Pre-clinical experience with full-wave inverse scattering for breast imaging: Sound speed sensitivity, Acoustical Imaging 29:73-80, Springer, Dordrecht, 2009.
MP Andre, C Barker, N Sekhon, J Wiskin, D Borup, K. Callahan: Pre-clinical experience with full-wave inverse scattering for breast imaging: Sound speed sensitivity, Acoustical Imaging 29:73-80, 2008.
Wiskin, J., 3-D Imaging Molecular Diagnostics: Inverse Scattering Algorithms, James Wiskin, Ph.D., Invited talk at the AACC sponsored 40th Annual Oak Ridge Conference - Breakthrough Technologies for Clinical Diagnostics , The Fairmont, San José, CA., American Assoc. of Clinical Chemists, San Jose California, April 17 - 18, 2008.
Wiskin, J. D. T. Borup, S.A. Johnson, M. Berggren, T. Abbott, R. Hanover, “Full-Wave, Non-linear, Inverse Scattering,” Acoustical Imaging, Vol. 28, p183-193,. M. Andre, editor, Springer, 2007
Johnson,S. T. Abbott, R. Bell, M Berggren, D. Borup, D. Robinson, J. Wiskin, S. Olsen, B. Hanover, “Non-Invasive Breast Tissue Characterization Using Ultrasound Speed and Attenuation,” , Acoustical Imaging, Vol. 28, p147-154, M. Andre, editor, Springer, 2007
Callahan, KS, DT Borup, SA Johnson, J Wiskin, Y Parisky, Transmission breast ultrasound Imaging representative case studies of speed of sound and attenuation of sound computed tomographic Images., 17th Annual National Interdisciplinary Breast Conference, , Las Vegas, NV., 2007
Wiskin, J., D. Borup, S. Johnson, M. Berggren, B. Hanover, S. Olsen, F. Setinsek, R. Hanover, and TSI staff, Full wave nonlinear inverse scattering for transmission breast imaging, 4th JOINT MEETING OF THE ACOUSTICAL SOCIETY OF AMERICA AND THE ACOUSTICAL SOCIETY OF JAPAN 28, Special session on: BIOMEDICAL ULTRASOUND/BIORESPONSE TO VIBRATION: (BB), Acoustic tomography in tissue., Nov. 2006
Wiskin, JW, DT Borup, SA Johnson, M Berggren, T. Abbott, R. Hanover, “Full Wave Nonlinear Inverse Scattering: High Resolution Quantitative Breast Tissue Tomography”, Invited Talk at the 28th Acoustical Imaging Symposium in San Diego, California, March 20-23, 2005.
Johnson, SA, R. Hanover, DT Borup, JW Wiskin, M Berggren, M Kammeyer, Scott Olsen, Jeff Pattee, F. Setinsek, K. Stewart, B. Hanover, “Design and first Clinical Implementation of the Ultrasound CT™ System for Breast Imaging”, Acoustical Imaging 28 Symposium in San Diego, California, March 20-23, 2005.
Johnson, SA, R. Hanover, DT Borup, JW Wiskin, M. Berggren, “Noninvasive Breast Tissue Characterization Using Ultrasound Speed and Attenuation: In Vivo Validation”, Acoustical Imaging 28 Symposium in San Diego, California, March 20-23, 2005
Kung-Shan Cheng, James W. Wiskin and Robert B. Roemer, “Advanced Fourier Marching Method for SAR Calculations in Thermal Therapies”, submitted to Hyperthermia, 2005
Wiskin, JW, Johnson, SA, Borup, DT., “Wave Propagation and Nonlinear Inversion in Layered or Moving Media - Fast Algorithms for High Contrasts,”, Soc. Indust. Appl. Math. Annual Meeting, Proceedings, San Diego, California, July 9-13, 2001.
Johnson, S. A., D. T. Borup, J W. Wiskin, M. J. Berggren, T. Guillerm, and S C. Olsen, “Fast, non-perturbative, transmission inverse scattering, quantitative imaging with laboratory and simulated acoustic data”, Invited lecture at 139th Meeting of the Acoustical Society of America, May, 2000.
Selected Publications
Wiskin J, Borup D, Andre M, Johnson S, Greenleaf J, Parisky Y, Klock J, Three-dimensional nonlinear inverse scattering: Quantitative transmission algorithms, refraction corrected reflection, scanner design, and clinical results. J Acoust Soc Am 2013 May;133(5):3229
Wiskin J, Borup DT, Johnson SA, Berggren M, Non-linear inverse scattering: high resolution quantitative breast tissue tomography. J Acoust Soc Am 2012 May;131(5):3802-13
Yuan X, Borup D, Wiskin J, Berggren M, Johnson SA, Simulation of acoustic wave propagation in dispersive media with relaxation losses by using FDTD method with PML absorbing boundary condition. IEEE Trans Ultrason Ferroelectr Freq Control 1999;46(1):14-23