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Russell J. Stewart

Phone: 801-581-8581
Office: 506C BPRB

Russell J. Stewart

Professor of Biomedical Engineering
PhD, 1989 Biochemistry
University of California, Santa Barbara


Biomimetic underwater adhesives, natural bioadhesives

Current Research

We study the natural underwater adhesives of the marine sandcastle worm and freshwater caddisfly larva with the goal of creating synthetic, water-borne, underwater adhesives. For more information visit our lab website.

Selected Publications

Lane DD, Fessler AK, Goo S, Williams DL, Stewart RJ, Sustained tobramycin release from polyphosphate double network hydrogels. Acta Biomater 2017 Mar 1;50:484-492

Stewart RJ, Wang CS, Song IT, Jones JP, The role of coacervation and phase transitions in the sandcastle worm adhesive system. Adv Colloid Interface Sci 2017 Jan;239:88-96

Ashton NN, Pan H, Stewart RJ, Connecting caddisworm silk structure and mechanical properties: combined infrared spectroscopy and mechanical analysis. Open Biol 2016 Jun;6(6):

Jones JP, Sima M, O'Hara RG, Stewart RJ, Water-Borne Endovascular Embolics Inspired by the Undersea Adhesive of Marine Sandcastle Worms. Adv Healthc Mater 2016 Apr 6;5(7):795-801

Papanna R, Moise KJ Jr, Mann LK, Fletcher S, Schniederjan R, Bhattacharjee MB, Stewart RJ, Kaur S, Prabhu SP, Tseng SC, Cryopreserved human umbilical cord patch for in-utero spina bifida repair. Ultrasound Obstet Gynecol 2016 Feb;47(2):168-76

Wang CS, Pan H, Weerasekare GM, Stewart RJ, Peroxidase-catalysed interfacial adhesion of aquatic caddisworm silk. J R Soc Interface 2015 Nov 6;12(112):

Lane DD, Kaur S, Weerasakare GM, Stewart RJ, Toughened hydrogels inspired by aquatic caddisworm silk. Soft Matter 2015 Sep 21;11(35):6981-90

Papanna R, Mann LK, Tseng SC, Stewart RJ, Kaur SS, Swindle MM, Kyriakides TR, Tatevian N, Moise KJ Jr, Cryopreserved human amniotic membrane and a bioinspired underwater adhesive to seal and promote healing of iatrogenic fetal membrane defect sites. Placenta 2015 Aug;36(8):888-94

Ashton NN, Stewart RJ, Self-recovering caddisfly silk: energy dissipating, Ca(2+)-dependent, double dynamic network fibers. Soft Matter 2015 Mar 7;11(9):1667-76

Wang CS, Ashton NN, Weiss RB, Stewart RJ, Peroxinectin catalyzed dityrosine crosslinking in the adhesive underwater silk of a casemaker caddisfly larvae, Hysperophylax occidentalis. Insect Biochem Mol Biol 2014 Nov;54:69-79

Ashton NN, Roe DR, Weiss RB, Cheatham TE 3rd, Stewart RJ, Self-tensioning aquatic caddisfly silk: Ca2+-dependent structure, strength, and load cycle hysteresis. Biomacromolecules 2013 Oct 14;14(10):3668-81

Wang CS, Stewart RJ, Multipart copolyelectrolyte adhesive of the sandcastle worm, Phragmatopoma californica (Fewkes): catechol oxidase catalyzed curing through peptidyl-DOPA. Biomacromolecules 2013 May 13;14(5):1607-17

Mann LK, Papanna R, Moise KJ Jr, Byrd RH, Popek EJ, Kaur S, Tseng SC, Stewart RJ, Fetal membrane patch and biomimetic adhesive coacervates as a sealant for fetoscopic defects. Acta Biomater 2012 Jul;8(6):2160-5

Ashton NN, Taggart DS, Stewart RJ, Silk tape nanostructure and silk gland anatomy of trichoptera. Biopolymers 2012 Jun;97(6):432-45

Brinton MR, Tagge CA, Stewart RJ, Cheung AK, Shiu YT, Christensen DA, Thermal sensitivity of endothelial cells on synthetic vascular graft material. Int J Hyperthermia 2012;28(2):163-74

Wang CS, Stewart RJ, Localization of the bioadhesive precursors of the sandcastle worm, Phragmatopoma californica (Fewkes). J Exp Biol 2012 Jan 15;215(Pt 2):351-61

Brinton MR, Stewart RJ, Cheung AK, Christensen DA, Shiu YT, Modelling ultrasound-induced mild hyperthermia of hyperplasia in vascular grafts. Theor Biol Med Model 2011 Nov 3;8:42

Stewart RJ, Wang CS, Shao H, Complex coacervates as a foundation for synthetic underwater adhesives. Adv Colloid Interface Sci 2011 Sep 14;167(1-2):85-93

Clark MR, Aliyar HA, Lee CW, Jay JI, Gupta KM, Watson KM, Stewart RJ, Buckheit RW, Kiser PF, Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles. Int J Pharm 2011 Jul 15;413(1-2):10-18

Stewart RJ, Ransom TC, Hlady V, Natural Underwater Adhesives. J Polym Sci B Polym Phys 2011 Jun;49(11):757-771

Kaur S, Weerasekare GM, Stewart RJ, Multiphase adhesive coacervates inspired by the sandcastle worm. ACS Appl Mater Interfaces 2011 Apr;3(4):941-4

Shao H, Weerasekare GM, Stewart RJ, Controlled curing of adhesive complex coacervates with reversible periodate carbohydrate complexes. J Biomed Mater Res A 2011 Apr;97(1):46-51

Stewart RJ, Protein-based underwater adhesives and the prospects for their biotechnological production. Appl Microbiol Biotechnol 2011 Jan;89(1):27-33

Winslow BD, Shao H, Stewart RJ, Tresco PA, Biocompatibility of adhesive complex coacervates modeled after the sandcastle glue of Phragmatopoma californica for craniofacial reconstruction. Biomaterials 2010 Dec;31(36):9373-81

Butterfield AE, Stewart RJ, Schmidt CF, Skliar M, Bidirectional power stroke by ncd kinesin. Biophys J 2010 Dec 15;99(12):3905-15

Stewart RJ, Wang CS, Adaptation of caddisfly larval silks to aquatic habitats by phosphorylation of h-fibroin serines. Biomacromolecules 2010 Apr 12;11(4):969-74

Shao H, Stewart RJ, Biomimetic underwater adhesives with environmentally triggered setting mechanisms. Adv Mater 2010 Feb 9;22(6):729-33

Shao H, Bachus KN, Stewart RJ, A water-borne adhesive modeled after the sandcastle glue of P. californica. Macromol Biosci 2009 May 13;9(5):464-71

Stevens MJ, Steren RE, Hlady V, Stewart RJ, Multiscale structure of the underwater adhesive of Phragmatopoma californica: a nanostructured latex with a steep microporosity gradient. Langmuir 2007 Apr 24;23(9):5045-9

Endrizzi BJ, Huang G, Kiser PF, Stewart RJ, Specific covalent immobilization of proteins through dityrosine cross-links. Langmuir 2006 Dec 19;22(26):11305-10

Stayner RS, Min DJ, Kiser PF, Stewart RJ, Site-specific cross-linking of proteins through tyrosine hexahistidine tags. Bioconjug Chem 2005 Nov-Dec;16(6):1617-23

Stewart RJ, Weaver JC, Morse DE, Waite JH, The tube cement of Phragmatopoma californica: a solid foam. J Exp Biol 2004 Dec;207(Pt 26):4727-34

Tang A, Wang C, Stewart RJ, Kopecek J, The coiled coils in the design of protein-based constructs: hybrid hydrogels and epitope displays. J Control Release 2001 May 14;72(1-3):57-70

Wang C, Kopecek J, Stewart RJ, Hybrid hydrogels cross-linked by genetically engineered coiled-coil block proteins. Biomacromolecules 2001 Fall;2(3):912-20

Chen L, Kopecek J, Stewart RJ, Responsive hybrid hydrogels with volume transitions modulated by a titin immunoglobulin module. Bioconjug Chem 2000 Sep-Oct;11(5):734-40

deCastro MJ, Fondecave RM, Clarke LA, Schmidt CF, Stewart RJ, Working strokes by single molecules of the kinesin-related microtubule motor ncd. Nat Cell Biol 2000 Oct;2(10):724-9

Min DJ, Andrade JD, Stewart RJ, Specific immobilization of in vivo biotinylated bacterial luciferase and FMN:NAD(P)H oxidoreductase. Anal Biochem 1999 May 15;270(1):133-9

deCastro MJ, Ho CH, Stewart RJ, Motility of dimeric ncd on a metal-chelating surfactant: evidence that ncd is not processive. Biochemistry 1999 Apr 20;38(16):5076-81

Wang C, Stewart RJ, Kopecek J, Hybrid hydrogels assembled from synthetic polymers and coiled-coil protein domains. Nature 1999 Feb 4;397(6718):417-20

Stewart RJ, Semerjian J, Schmidt CF, Highly processive motility is not a general feature of the kinesins. Eur Biophys J 1998;27(4):353-60

Wang CY, Hitz S, Andrade JD, Stewart RJ, Specific immobilization of firefly luciferase through a biotin carboxyl carrier protein domain. Anal Biochem 1997 Mar 1;246(1):133-9