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Patrick A. Tresco

Phone: 801-581-8873
Office: 4511 Sorenson Molecular Biotechnology Building (SMBB)

Patrick A. Tresco

MS, Pharmacology & Toxicology
University of Rhode Island
PhD, Medical Sciences
Brown University


Biomaterials and Tissue engineering, as applied to neural interfaces/neuroscience/ connective tissue

Current Research

Our group is focused on reducing inflammation at the biotic abiotic interface, and developing technology for for targeting nerve outgrowth. A central theme in our work involves understanding how to better integrate medical devices into the nervous system including stimulating and recording electrodes and bridging devices that vary in their physical and chemical properties. In addition, we are developing force generating bioreactors for studying how the microenvironment of connective tissue influences its composition and function, and have recently developed a novel approach for harvesting ECM from cells cultured in vitro.

Selected Publications

Hsiao TW, Tresco PA, Hlady V, Astrocyte spreading and migration on aggrecan-laminin dot gradients. Biointerphases 2017 Sep 11;13(1):01A401

Christensen MB, Tresco PA, Differences Exist in the Left and Right Sciatic Nerves of Na´ve Rats and Cats. Anat Rec (Hoboken) 2015 Aug;298(8):1492-501

Nolta NF, Christensen MB, Crane PD, Skousen JL, Tresco PA, BBB leakage, astrogliosis, and tissue loss correlate with silicon microelectrode array recording performance. Biomaterials 2015;53:753-62

Hsiao TW, Tresco PA, Hlady V, Astrocytes alignment and reactivity on collagen hydrogels patterned with ECM proteins. Biomaterials 2015 Jan;39:124-30

Skousen JL, Bridge MJ, Tresco PA, A strategy to passively reduce neuroinflammation surrounding devices implanted chronically in brain tissue by manipulating device surface permeability. Biomaterials 2015 Jan;36:33-43

Christensen MB, Pearce SM, Ledbetter NM, Warren DJ, Clark GA, Tresco PA, The foreign body response to the Utah Slant Electrode Array in the cat sciatic nerve. Acta Biomater 2014 Nov;10(11):4650-4660

Hsiao TW, Swarup VP, Kuberan B, Tresco PA, Hlady V, Astrocytes specifically remove surface-adsorbed fibrinogen and locally express chondroitin sulfate proteoglycans. Acta Biomater 2013 Jul;9(7):7200-8

Hodgkinson GN, Tresco PA, Hlady V, The role of well-defined patterned substrata on the regeneration of DRG neuron pathfinding and integrin expression dynamics using chondroitin sulfate proteoglycans. Biomaterials 2012 Jun;33(17):4288-97

Meng F, Hlady V, Tresco PA, Inducing alignment in astrocyte tissue constructs by surface ligands patterned on biomaterials. Biomaterials 2012 Feb;33(5):1323-35

Tresco PA, Winslow BD, The challenge of integrating devices into the central nervous system. Crit Rev Biomed Eng 2011;39(1):29-44

Skousen JL, Merriam SM, Srivannavit O, Perlin G, Wise KD, Tresco PA, Reducing surface area while maintaining implant penetrating profile lowers the brain foreign body response to chronically implanted planar silicon microelectrode arrays. Prog Brain Res 2011;194:167-80

Winslow BD, Christensen MB, Yang WK, Solzbacher F, Tresco PA, A comparison of the tissue response to chronically implanted Parylene-C-coated and uncoated planar silicon microelectrode arrays in rat cortex. Biomaterials 2010 Dec;31(35):9163-72

Wolchok JC, Tresco PA, The isolation of cell derived extracellular matrix constructs using sacrificial open-cell foams. Biomaterials 2010 Dec;31(36):9595-603

Winslow BD, Shao H, Stewart RJ, Tresco PA, Biocompatibility of adhesive complex coacervates modeled after the sandcastle glue of Phragmatopoma californica for craniofacial reconstruction. Biomaterials 2010 Dec;31(36):9373-81

Winslow BD, Tresco PA, Quantitative analysis of the tissue response to chronically implanted microwire electrodes in rat cortex. Biomaterials 2010 Mar;31(7):1558-67

Wolchok JC, Brokopp C, Underwood CJ, Tresco PA, The effect of bioreactor induced vibrational stimulation on extracellular matrix production from human derived fibroblasts. Biomaterials 2009 Jan;30(3):327-35

Hodgkinson GN, Tresco PA, Hlady V, The influence of sub-micron inhibitory clusters on growth cone substratum attachments and CD44 expression. Biomaterials 2008 Nov;29(31):4227-35

Smeal RM, Tresco PA, The influence of substrate curvature on neurite outgrowth is cell type dependent. Exp Neurol 2008 Oct;213(2):281-92

Gupta KM, Pearce SM, Poursaid AE, Aliyar HA, Tresco PA, Mitchnik MA, Kiser PF, Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1. J Pharm Sci 2008 Oct;97(10):4228-39

Leung BK, Biran R, Underwood CJ, Tresco PA, Characterization of microglial attachment and cytokine release on biomaterials of differing surface chemistry. Biomaterials 2008 Aug;29(23):3289-97

Biran R, Martin DC, Tresco PA, The brain tissue response to implanted silicon microelectrode arrays is increased when the device is tethered to the skull. J Biomed Mater Res A 2007 Jul;82(1):169-78

Hodgkinson GN, Tresco PA, Hlady V, The differential influence of colocalized and segregated dual protein signals on neurite outgrowth on surfaces. Biomaterials 2007 Jun;28(16):2590-602

Kim YT, Bridge MJ, Tresco PA, The influence of the foreign body response evoked by fibroblast transplantation on soluble factor diffusion in surrounding brain tissue. J Control Release 2007 Apr 23;118(3):340-7

Wen X, Tresco PA, Fabrication and characterization of permeable degradable poly(DL-lactide-co-glycolide) (PLGA) hollow fiber phase inversion membranes for use as nerve tract guidance channels. Biomaterials 2006 Jul;27(20):3800-9

House PA, MacDonald JD, Tresco PA, Normann RA, Acute microelectrode array implantation into human neocortex: preliminary technique and histological considerations. Neurosurg Focus 2006 May 15;20(5):E4

Wen X, Tresco PA, Effect of filament diameter and extracellular matrix molecule precoating on neurite outgrowth and Schwann cell behavior on multifilament entubulation bridging device in vitro. J Biomed Mater Res A 2006 Mar 1;76(3):626-37

Webb K, Hitchcock RW, Smeal RM, Li W, Gray SD, Tresco PA, Cyclic strain increases fibroblast proliferation, matrix accumulation, and elastic modulus of fibroblast-seeded polyurethane constructs. J Biomech 2006;39(6):1136-44

Merrill DR, Tresco PA, Impedance characterization of microarray recording electrodes in vitro. IEEE Trans Biomed Eng 2005 Nov;52(11):1960-5

Biran R, Martin DC, Tresco PA, Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. Exp Neurol 2005 Sep;195(1):115-26

Walsh JF, Manwaring ME, Tresco PA, Directional neurite outgrowth is enhanced by engineered meningeal cell-coated substrates. Tissue Eng 2005 Jul-Aug;11(7-8):1085-94

Smeal RM, Rabbitt R, Biran R, Tresco PA, Substrate curvature influences the direction of nerve outgrowth. Ann Biomed Eng 2005 Mar;33(3):376-82

Kim YT, Hitchcock R, Broadhead KW, Messina DJ, Tresco PA, A cell encapsulation device for studying soluble factor release from cells transplanted in the rat brain. J Control Release 2005 Jan 20;102(1):101-11

Massey BL, Wen X, Rohr LR, Tresco PA, Dahlstrom L, Park AH, Resorption rate and biocompatibility characteristics of two polyester ventilation tubes in a guinea pig model. Otolaryngol Head Neck Surg 2004 Dec;131(6):921-5

Liu Y, Webb K, Kirker KR, Bernshaw NJ, Tresco PA, Gray SD, Prestwich GD, Composite articular cartilage engineered on a chondrocyte-seeded aliphatic polyurethane sponge. Tissue Eng 2004 Jul-Aug;10(7-8):1084-92

Manwaring ME, Walsh JF, Tresco PA, Contact guidance induced organization of extracellular matrix. Biomaterials 2004 Aug;25(17):3631-8

Kim YT, Hitchcock RW, Bridge MJ, Tresco PA, Chronic response of adult rat brain tissue to implants anchored to the skull. Biomaterials 2004 May;25(12):2229-37

Merrill DR, Tresco PA, Impedance characterization of microarray recording electrodes in vitro. Conf Proc IEEE Eng Med Biol Soc 2004;6:4349-52

Messina DJ, Alder L, Tresco PA, Comparison of pure and mixed populations of human fetal-derived neural progenitors transplanted into intact adult rat brain. Exp Neurol 2003 Dec;184(2):816-29

Biran R, Noble MD, Tresco PA, Directed nerve outgrowth is enhanced by engineered glial substrates. Exp Neurol 2003 Nov;184(1):141-52

Webb K, Li W, Hitchcock RW, Smeal RM, Gray SD, Tresco PA, Comparison of human fibroblast ECM-related gene expression on elastic three-dimensional substrates relative to two-dimensional films of the same material. Biomaterials 2003 Nov;24(25):4681-90

Broadhead KW, Biran R, Tresco PA, Hollow fiber membrane diffusive permeability regulates encapsulated cell line biomass, proliferation, and small molecule release. Biomaterials 2002 Dec;23(24):4689-99

Manwaring ME, Biran R, Tresco PA, Characterization of rat meningeal cultures on materials of differing surface chemistry. Biomaterials 2001 Dec;22(23):3155-68

Webb K, Budko E, Neuberger TJ, Chen S, Schachner M, Tresco PA, Substrate-bound human recombinant L1 selectively promotes neuronal attachment and outgrowth in the presence of astrocytes and fibroblasts. Biomaterials 2001 May;22(10):1017-28

Biran R, Webb K, Noble MD, Tresco PA, Surfactant-immobilized fibronectin enhances bioactivity and regulates sensory neurite outgrowth. J Biomed Mater Res 2001 Apr;55(1):1-12

Webb K, Caldwell KD, Tresco PA, A novel surfactant-based immobilization method for varying substrate-bound fibronectin. J Biomed Mater Res 2001 Mar 15;54(4):509-18

Tresco PA, Biran R, Noble MD, Cellular transplants as sources for therapeutic agents. Adv Drug Deliv Rev 2000 Aug 20;42(1-2):3-27

Webb K, Hlady V, Tresco PA, Relationships among cell attachment, spreading, cytoskeletal organization, and migration rate for anchorage-dependent cells on model surfaces. J Biomed Mater Res 2000 Mar 5;49(3):362-8

Tresco PA, Tissue engineering strategies for nervous system repair. Prog Brain Res 2000;128:349-63

Neff JA, Tresco PA, Caldwell KD, Surface modification for controlled studies of cell-ligand interactions. Biomaterials 1999 Dec;20(23-24):2377-93

Biran R, Noble MD, Tresco PA, Characterization of cortical astrocytes on materials of differing surface chemistry. J Biomed Mater Res 1999 Aug;46(2):150-9

Ghanem TA, Rabbitt RD, Tresco PA, Three-dimensional reconstruction of the membranous vestibular labyrinth in the toadfish, Opsanus tau. Hear Res 1998 Oct;124(1-2):27-43

Webb K, Hlady V, Tresco PA, Relative importance of surface wettability and charged functional groups on NIH 3T3 fibroblast attachment, spreading, and cytoskeletal organization. J Biomed Mater Res 1998 Sep 5;41(3):422-30

Neff JA, Caldwell KD, Tresco PA, A novel method for surface modification to promote cell attachment to hydrophobic substrates. J Biomed Mater Res 1998 Jun 15;40(4):511-9

Mulder MM, Hitchcock RW, Tresco PA, Skeletal myogenesis on elastomeric substrates: implications for tissue engineering. J Biomater Sci Polym Ed 1998;9(7):731-48