Personal Profile
Jeffrey A. Weiss
Professor
Adjunct Professor, Department of Orthopedics
Faculty Member, Scientific Computing and Imaging Institute
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Fellow, American Institute for Medical and Biological Engineering, 2006-
ASME YC Fung Young Investigator Award Recipient, May 2002
NSF CAREE
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1990 - 1994: Ph.D., Bioengineering, University of Utah
1988 - 1990: M.S., Bioengineering, University of California, San Diego
1984 - 1989: B.S., Bioengineering, University of California, San Diego
Research
Experimental and Computational Biomechanics; Mechanics of Angiogenesis
Current Research
Origins of Elasticity and Viscoelasticity in Ligaments (PI; NIH/NIAMS #R01 AR047369)
Biomechanics of the Dysplastic Hip (PI; NIH/NIAMS #R01 AR053344)
Angiogenesis and the Extracellular Matrix (PI; NIH/NHLBI #R01 HL077683)
FEBio: Finite Elements for Biomechanics (PI; NIH/NIGMS #R01 GM083925)
Predicting Cell Deformation from Body Level Mechanical Loads (Co-I; NIH/NIBIB #R01 EB009643)
Mechanisms Impairing Finger Extension Following Stroke (Co-I; NIH/NINDS #R01 NS052369)
Fabricated Microvascular Networks (Co-I; NIH/NHLBI #R01 EB007556)
Research in the Musculoskeletal Research Laboratories has historically focused on the injury, healing and repair of musculoskeletal soft tissues, in particular the ligaments of the knee. Our research focus has expanded considerably over the past 5 years to include hard tissue as well as cardiovascular tissues including the heart, coronary arteries and smaller vessels involved in angiogenesis. A central theme of our approach to research is the use of multidisciplinary techniques. A primary strength of the MRL continues to be the combination of both experimental and computational techniques, especially in the area of biomechanics, to address research questions that would be impossible to investigate using approaches in a single technical discipline.
Biomechanics of the Dysplastic Hip (PI; NIH/NIAMS #R01 AR053344)
Angiogenesis and the Extracellular Matrix (PI; NIH/NHLBI #R01 HL077683)
FEBio: Finite Elements for Biomechanics (PI; NIH/NIGMS #R01 GM083925)
Predicting Cell Deformation from Body Level Mechanical Loads (Co-I; NIH/NIBIB #R01 EB009643)
Mechanisms Impairing Finger Extension Following Stroke (Co-I; NIH/NINDS #R01 NS052369)
Fabricated Microvascular Networks (Co-I; NIH/NHLBI #R01 EB007556)
Research in the Musculoskeletal Research Laboratories has historically focused on the injury, healing and repair of musculoskeletal soft tissues, in particular the ligaments of the knee. Our research focus has expanded considerably over the past 5 years to include hard tissue as well as cardiovascular tissues including the heart, coronary arteries and smaller vessels involved in angiogenesis. A central theme of our approach to research is the use of multidisciplinary techniques. A primary strength of the MRL continues to be the combination of both experimental and computational techniques, especially in the area of biomechanics, to address research questions that would be impossible to investigate using approaches in a single technical discipline.
Selected Publications
Harris MD, Reese SP, Peters CL, Weiss JA, Anderson AE, Three-dimensional Quantification of Femoral Head Shape in Controls and Patients with Cam-type Femoroacetabular Impingement. Ann Biomed Eng 2013 Jun;41(6):1162-71
Abraham CL, Maas SA, Weiss JA, Ellis BJ, Peters CL, Anderson AE, A new discrete element analysis method for predicting hip joint contact stresses. J Biomech 2013 Apr 5;46(6):1121-7
Reese SP, Underwood CJ, Weiss JA, Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels. Matrix Biol 2013 Apr 20;():
Henninger HB, Underwood CJ, Romney SJ, Davis GL, Weiss JA, Effect of Elastin Digestion on the Quasi-Static Tensile Response of Medial Collateral Ligament. J Orthop Res 2013 Mar 28;():
Henak CR, Anderson AE, Weiss JA, Subject-specific analysis of joint contact mechanics: application to the study of osteoarthritis and surgical planning. J Biomech Eng 2013 Feb;135(2):021003
Reese SP, Ellis BJ, Weiss JA, Micromechanical model of a surrogate for collagenous soft tissues: development, validation and analysis of mesoscale size effects. Biomech Model Mechanobiol 2013 Feb 12;():
Harris MD, Anderson AE, Henak CR, Ellis BJ, Peters CL, Weiss JA, Finite element prediction of cartilage contact stresses in normal human hips. J Orthop Res 2012 Jul;30(7):1133-9
Hansen BJ, Harris MD, Anderson LA, Peters CL, Weiss JA, Anderson AE, Correlation between radiographic measures of acetabular morphology with 3D femoral head coverage in patients with acetabular retroversion. Acta Orthop 2012 Jun;83(3):233-9
Edgar LT, Sibole SC, Underwood CJ, Guilkey JE, Weiss JA, A computational model of in vitro angiogenesis based on extracellular matrix fibre orientation. Comput Methods Biomech Biomed Engin 2012 Apr 19;():
Maas SA, Ellis BJ, Ateshian GA, Weiss JA, FEBio: finite elements for biomechanics. J Biomech Eng 2012 Jan;134(1):011005
Henak CR, Ellis BJ, Harris MD, Anderson AE, Peters CL, Weiss JA, Role of the acetabular labrum in load support across the hip joint. J Biomech 2011 Aug 11;44(12):2201-6
Peters CL, Anderson LA, Erickson JA, Anderson AE, Weiss JA, An algorithmic approach to surgical decision making in acetabular retroversion. Orthopedics 2011 Jan 3;34(1):10
Henninger HB, Underwood CJ, Ateshian GA, Weiss JA, Effect of sulfated glycosaminoglycan digestion on the transverse permeability of medial collateral ligament. J Biomech 2010 Sep 17;43(13):2567-73
Ellis BJ, Drury NJ, Moore SM, McMahon PJ, Weiss JA, Debski RE, Finite element modelling of the glenohumeral capsule can help assess the tested region during a clinical exam. Comput Methods Biomech Biomed Engin 2010 Jun;13(3):413-8
Anderson AE, Ellis BJ, Maas SA, Weiss JA, Effects of idealized joint geometry on finite element predictions of cartilage contact stresses in the hip. J Biomech 2010 May 7;43(7):1351-7
Reese SP, Maas SA, Weiss JA, Micromechanical models of helical superstructures in ligament and tendon fibers predict large Poisson's ratios. J Biomech 2010 May 7;43(7):1394-400
Henninger HB, Reese SP, Anderson AE, Weiss JA, Validation of computational models in biomechanics. Proc Inst Mech Eng H 2010;224(7):801-12
Phatak NS, Maas SA, Veress AI, Pack NA, Di Bella EV, Weiss JA, Strain measurement in the left ventricle during systole with deformable image registration. Med Image Anal 2009 Apr;13(2):354-61
Henninger HB, Maas SA, Shepherd JH, Joshi S, Weiss JA, Transversely isotropic distribution of sulfated glycosaminoglycans in human medial collateral ligament: a quantitative analysis. J Struct Biol 2009 Mar;165(3):176-83
Lujan TJ, Underwood CJ, Jacobs NT, Weiss JA, Contribution of glycosaminoglycans to viscoelastic tensile behavior of human ligament. J Appl Physiol 2009 Feb;106(2):423-31
Anderson AE, Ellis BJ, Maas SA, Peters CL, Weiss JA, Validation of finite element predictions of cartilage contact pressure in the human hip joint. J Biomech Eng 2008 Oct;130(5):051008
Veress AI, Weiss JA, Huesman RH, Reutter BW, Taylor SE, Sitek A, Feng B, Yang Y, Gullberg GT, Measuring regional changes in the diastolic deformation of the left ventricle of SHR rats using microPET technology and hyperelastic warping. Ann Biomed Eng 2008 Jul;36(7):1104-17
Krishnan L, Underwood CJ, Maas S, Ellis BJ, Kode TC, Hoying JB, Weiss JA, Effect of mechanical boundary conditions on orientation of angiogenic microvessels. Cardiovasc Res 2008 May 1;78(2):324-32
Anderson AE, Ellis BJ, Peters CL, Weiss JA, Cartilage thickness: factors influencing multidetector CT measurements in a phantom study. Radiology 2008 Jan;246(1):133-41
Krishnan L, Hoying JB, Nguyen H, Song H, Weiss JA, Interaction of angiogenic microvessels with the extracellular matrix. Am J Physiol Heart Circ Physiol 2007 Dec;293(6):H3650-8
Phatak NS, Sun Q, Kim SE, Parker DL, Sanders RK, Veress AI, Ellis BJ, Weiss JA, Noninvasive determination of ligament strain with deformable image registration. Ann Biomed Eng 2007 Jul;35(7):1175-87
Lujan TJ, Underwood CJ, Henninger HB, Thompson BM, Weiss JA, Effect of dermatan sulfate glycosaminoglycans on the quasi-static material properties of the human medial collateral ligament. J Orthop Res 2007 Jul;25(7):894-903
Anderson AE, Ellis BJ, Weiss JA, Verification, validation and sensitivity studies in computational biomechanics. Comput Methods Biomech Biomed Engin 2007 Jun;10(3):171-84
Lujan TJ, Dalton MS, Thompson BM, Ellis BJ, Weiss JA, Effect of ACL deficiency on MCL strains and joint kinematics. J Biomech Eng 2007 Jun;129(3):386-92
Henninger HB, Maas SA, Underwood CJ, Whitaker RT, Weiss JA, Spatial distribution and orientation of dermatan sulfate in human medial collateral ligament. J Struct Biol 2007 Apr;158(1):33-45
Ellis BJ, Debski RE, Moore SM, McMahon PJ, Weiss JA, Methodology and sensitivity studies for finite element modeling of the inferior glenohumeral ligament complex. J Biomech 2007;40(3):603-12
Ionescu I, Guilkey JE, Berzins M, Kirby RM, Weiss JA, Simulation of soft tissue failure using the material point method. J Biomech Eng 2006 Dec;128(6):917-24
Veress AI, Segars WP, Weiss JA, Tsui BM, Gullberg GT, Normal and pathological NCAT image and phantom data based on physiologically realistic left ventricle finite-element models. IEEE Trans Med Imaging 2006 Dec;25(12):1604-16
Ellis BJ, Lujan TJ, Dalton MS, Weiss JA, Medial collateral ligament insertion site and contact forces in the ACL-deficient knee. J Orthop Res 2006 Apr;24(4):800-10
Ionescu I, Weiss JA, Guilkey J, Cole M, Kirby RM, Berzins M, Ballistic injury simulation using the material point method. Stud Health Technol Inform 2006;119():228-33
Weiss JA, Maakestad BJ, Permeability of human medial collateral ligament in compression transverse to the collagen fiber direction. J Biomech 2006;39(2):276-83
Guilkey JE, Hoying JB, Weiss JA, Computational modeling of multicellular constructs with the material point method. J Biomech 2006;39(11):2074-86
Veress AI, Gullberg GT, Weiss JA, Measurement of strain in the left ventricle during diastole with cine-MRI and deformable image registration. J Biomech Eng 2005 Dec;127(7):1195-207
Weiss JA, Gardiner JC, Ellis BJ, Lujan TJ, Phatak NS, Three-dimensional finite element modeling of ligaments: technical aspects. Med Eng Phys 2005 Dec;27(10):845-61
Anderson AE, Peters CL, Tuttle BD, Weiss JA, Subject-specific finite element model of the pelvis: development, validation and sensitivity studies. J Biomech Eng 2005 Jun;127(3):364-73
Lujan TJ, Lake SP, Plaizier TA, Ellis BJ, Weiss JA, Simultaneous measurement of three-dimensional joint kinematics and ligament strains with optical methods. J Biomech Eng 2005 Feb;127(1):193-7
Bonifasi-Lista C, Lake SP, Small MS, Weiss JA, Viscoelastic properties of the human medial collateral ligament under longitudinal, transverse and shear loading. J Orthop Res 2005 Jan;23(1):67-76
Shiu YT, Weiss JA, Hoying JB, Iwamoto MN, Joung IS, Quam CT, The role of mechanical stresses in angiogenesis. Crit Rev Biomed Eng 2005;33(5):431-510
Krishnan L, Weiss JA, Wessman MD, Hoying JB, Design and application of a test system for viscoelastic characterization of collagen gels. Tissue Eng 2004 Jan-Feb;10(1-2):241-52
Gardiner JC, Weiss JA, Subject-specific finite element analysis of the human medial collateral ligament during valgus knee loading. J Orthop Res 2003 Nov;21(6):1098-106
Veress AI, Weiss JA, Gullberg GT, Vince DG, Rabbitt RD, Strain measurement in coronary arteries using intravascular ultrasound and deformable images. J Biomech Eng 2002 Dec;124(6):734-41
Weiss JA, Gardiner JC, Bonifasi-Lista C, Ligament material behavior is nonlinear, viscoelastic and rate-independent under shear loading. J Biomech 2002 Jul;35(7):943-50
Hansen KA, Weiss JA, Barton J , Recruitment of tendon crimp with applied tensile strain. J Biomech Eng 2002 Feb;124(1):72-7
Gardiner JC, Weiss JA, Rosenberg TD, Strain in the human medial collateral ligament during valgus loading of the knee. Clin Orthop Relat Res 2001 Oct;(391):266-74
Gardiner JC, Weiss JA, Simple shear testing of parallel-fibered planar soft tissues. J Biomech Eng 2001 Apr;123(2):170-5
Weiss JA, Gardiner JC, Computational modeling of ligament mechanics. Crit Rev Biomed Eng 2001;29(3):303-71
Quapp KM, Weiss JA, Material characterization of human medial collateral ligament. J Biomech Eng 1998 Dec;120(6):757-63
Puso MA, Weiss J , Finite element implementation of anisotropic quasi-linear viscoelasticity using a discrete spectrum approximation. J Biomech Eng 1998 Feb;120(1):62-70
Straight CB, France EP, Paulos LE, Rosenberg TD, Weiss JA, Soft tissue fixation to bone. A biomechanical analysis of spiked washers. Am J Sports Med 1994 May-Jun;22(3):339-43
Weiss JA, Woo SL, Ohland KJ, Horibe S, Newton P , Evaluation of a new injury model to study medial collateral ligament healing: primary repair versus nonoperative treatment. J Orthop Res 1991 Jul;9(4):516-28