Vladimir Hlady, D.Sc.

Address:

Department of Bioengineering, 108 A BPRB

University of Utah, Salt Lake City, UT 84112

phone (801) 581-5042 ,

fax (801) 585-5151

e-mail: Vladimir.Hlady@m.cc.utah.edu

HLADY GROUP RESEARCH WEB SITE: Hlady Research Group

Research in the Hlady Group in the Department of Bioengineering at the University of Utah focuses on molecular processes which occur at interfaces and involve biological macromolecules and man-made materials.

Current projects include the study of plasma protein adsorption kinetics and its regulation by materials surface chemistry, the use of proteins at interfaces as transducers of recognition events and the study of cells at biomaterial surfaces.

The biomaterials surface research is focussed on development of biomimetic surface coatings based on hydrophilic macromolecules and/or on transferred Langmuir-Blodgett films, the nano-mechanical characterization of surfaces using SFM elasticity and adhesion mapping.

Other studies involve the use of mixed lipids Langmuir monolayers as a 2-D templates for the macromolecules and virus particle binding and recognition, and for the nucleation of inorganic phases.

Dr. Vladimir Hlady also serves as a Director of The Center for Biopolymers at Interfaces.

TEACHING

BIOEN 7160: "Physical Nature of Surfaces" (2 cr. hrs) (Fall 1999)

BIOEN 7164: "Polymer Surface Characterization" course (3 cr. hrs) (Spring 2000)

BIOEN 7168: "Proteins at Interfaces, on Surfaces and in Membranes" (2 cr. hrs) (Spring 2001)

BIOEN 7150: "Biomimetic Engineering" (2 cr. hrs) (Fall 2000)

SELECTED PUBLICATIONS

• V. Hlady and J. Buijs: Optical Spectroscopy of Adsorbed Protein Layer, a chapter in "Biopolymers at Interfaces" (M. Malmsten, Ed), M. Dekker, in press, 1998.
  V. Hlady and J. Buijs: Protein adsorption on solid surfaces, a yearly review in Current Opinion in Biotechnology 7 (1996) 72 - 77.
• V. Hlady: Spectroscopic and other techniques for studying adsorption of bioproducts at interfaces, a chapter in "Interfacial Phenomena and Bioproducts" (J. L. Brash and P. Wojciechowski, Eds). M. Dekker, New York, 1996, pp 231- 255.
• J. Buijs, D. W. Britt and V. Hlady: Human Growth Hormone Adsorption Kinetics and Conformation on Self-Assembled Monolayers" Langmuir, 14 (1998) 335-341.
• J. Buijs and V. Hlady: Adsorption kinetics, conformation and mobility of growth hormone and lysozyme on solid surfaces, studied with TIRF, J. Colloid Interface Sci., 190 (1997) 171 -181.
• D. W. Britt and V. Hlady, In situ AFM imaging of calcite etch pit morphology changes in undersaturated and HEDP-poisonde solutions, Langmuir, 13 (1997) 1873 - 1876.
• E. W. Stroup, A. Pungor and V. Hlady, A constant compliance force modulation technique for SFM imaging of polymer surface elasticity, Ultramicroscopy, 66 (1997) 237 - 249.
  

Link to Department of Bioengineering home page.