Recent Journal Papers

Smeal RM, Rabbitt R, Biran R, and PA Tresco, Substrate curvature influences the direction of neurite outgrowth, Ann Biomed Eng, 2005 Mar;33(3):376-82. [Link]

Kim YT, Hitchcock R, Broadhead KW, Messina DJ, and PA Tresco, A cell encapsulation device for studying soluble factor release from cells transplanted in the rat brain, J Control Release, 2005 Jan 20;102(1):101-11. [Link]

Massey BL, Wen X, Rohr LR, Tresco PA, Dahlstrom L, and AH Park, Resorption rate and biocompatibility characteristics of two polyester ventilation tubes in a guinea pig model, Otolaryngol Head Neck Surg, 2004 Dec;131(6):921-5. [Link]

Titze IR, Hitchcock RW, Broadhead K, Webb K, Li W, Gray SD, and PA Tresco, Design and validation of a bioreactor for engineering vocal fold tissues under combined tensile and vibrational stresses, J Biomech, 2004 Oct;37(10):1521-9. [Link]

Mejis MF, Timmers L, Pearse DD, Tresco PA, Bates ML, Joosten EA, Bunge MB, and M Oudega, Basic fibroblast growth factor promotes neuronal survival but not behavioral recovery in the transected and Schwann cell implanted rat thoracic spinal cord, Exp Neurol, 2004 Oct;21(10):1415-30. [Link]

Manwaring ME, Walsh JF, and PA Tresco, Contact guidance induced organization of extracellular matrix, Biomaterials, 2004 Aug;25(17):3631-8. [Link]

Liu Y, Webb K, Kirker KR, Bernshaw NJ, Tresco PA, Gray SD, and GD Prestwich, Composite articular cartilage engineered on a chondrocyte-seeded aliphatic polyurethane sponge, Tissue Eng, 2004 Jul-Aug; 10(7-8):1084-92. [Link]

Kim, Y-T, Hitchcock RW, Bridge MJ, and PA Tresco, Chronic response of adult rat brain tissue to implants anchored to the skull, Biomaterials, 2004 May; 25:2229-37. [Link]

Messina DJ, Alder L, and PA Tresco, Comparison of pure and mixed populations of human fetal-derived neural progenitors transplanted into intact adult rat brain, Exp Neurol, 2003 Dec; 184:816-29. [Link]

Biran R, Noble MD, and PA Tresco, Directed nerve outgrowth is enhanced by engineered glial substrates, Exp Neurol, 2003 Nov; 184:141-52. [Link]

Gray S, Thibeault S, and P Tresco, Witnessing a revolution in voice research: genomics, tissue engineering, biochips, and what's next! Logoped Phoniatr Vocol, 2003; 28(1):7-13; discussion 14-7. [Link]

Webb K, Li W, Hitchcock RW, Smeal RM, Gray SD, and Tresco PA, Comparison of human fibroblast ECM-related gene expression on elastic three-dimensional substrates relative to two-dimensional films of the same material, Biomaterials, 2003 Nov; 24:4681-90. [Link]

Broadhead KW, Biran R, and PA Tresco, Hollow fiber membrane diffusive permeability regulates encapsulated cell line biomass, proliferation, and small molecule release, Biomaterials, 2002 Dec; 23:4689-99. [Link]

Manwaring ME, Biran R, and PA Tresco, Characterization of rat meningeal cultures on materials of differing surface chemistry, Biomaterials, 2001 Dec; 22:3155-68. [Link]

Bridge MJ, Broadhead KW, Hlady V, and PA Tresco, Ethanol treatment alters the ultrastructure and permeability of PAN-PVC hollow fiber cell encapsulation membranes, J Membrane Sci, 2001 Oct; 195:51-64. [Link]

Herrera J, Yang H, Zhang, S-C, Proschel C, Tresco P, Duncan ID, Luskin M, and M. Mayer-Proschel, Embryonic-derived glial-restricted precursor cells (GRP cells) can differentiate into astrocytes and oligodendrocytes in vivo, Exp Neurol, 2001 Sept; 171(1):11-21. [Link]

Bridge MJ, Broadhead KW, Hitchcock RW, Webb K, and PA Tresco, A simple instrument to characterize convective and diffusive transport of single hollow fibers of short length, J Membrane Sci, 2001 Mar; 183:223-33. [Link]

Webb K, Budko E, Neuberger TJ, Chen S, Schachner M and PA Tresco, Substrate-bound human recombinant L1 selectively promotes neuronal attachment and outgrowth in the presence of astrocytes and fibroblasts, Biomaterials, 2001 May; 22(10):1017-28. [Link]

Biran R, Webb K, Noble MD, and PA Tresco, Surfactant-immobilized fibronectin enhances bioactivity and regulates sensory neurite outgrowth, J Biomed Mater Res, 2001 Apr; 55(1):1-12. [Link]

Webb K, Caldwell KD, and PA Tresco, A novel surfactant-based immobilization method for varying substrate-bound fibronectin, J Biomed Mater Res, 2001 Mar; 54(4):509-18. [Link]

Tresco PA, Biran R, and MD Noble, Cellular transplants as sources for therapeutic agents, Adv Drug Deliv Rev, 2000 Aug;42(1-2):3-27. [Link]

Uludag H, De Vos P, and PA Tresco, Technology of mammalian cell encapsulation, Adv Drug Deliv Rev, 2000 Aug;42(1-2):29-64. [Link]

Webb K, Hlady V, and PA Tresco, Relationships among cell attachment, spreading, cytoskeletal organization, and migration rate for anchorage-dependent cells on model surfaces, J Biomed Mater Res, 2000 Mar;49(3):362-368. [Link]

Webb K, Caldwell K, and PA Tresco, Fibronectin immobilized by a novel surface treatment regulates fibroblast attachment and spreading, Crit Rev Biomed Eng, 2000;28(1-2):203-208. [Link]

Mensinger AF, Anderson DJ, Buchko CJ, Johnson MA, Martin DC, Tresco PA, Silver RB, and SM Highstein, Chronic recording of regenerating VIIIth nerve axons with a sieve electrode, J Neurophysiol, 2000 Jan;83(1):611-615. [Link]

Tresco PA, Tissue engineering strategies for nervous system repair, Prog Brain Res, 2000;128:349-363. [Link]

Recent Conference Papers

Leung BK, Underwood CJ, and PA Tresco, (2005) Cytokine secretion by primary microglia as a function of surface chemistry and rat strain, 30th Annual Meeting Transactions, Society for Biomaterials, 682.

Leung BK, Williamson TP, and PA Tresco, (2005) CNS tissue response to implanted microelectrodes appears to be rat strain dependent, 30th Annual Meeting Transactions, Society for Biomaterials, 684.

Roberts MC, Wen X, and PA Tresco, (2005) Fabrication and in vitro degradation of PLGA tympanostomy tubes, 30th Annual Meeting Transactions, Society for Biomaterials, 390.

Merrill DR, Leung BK, Winslow BD, Kim Y-T, Underwood CJ, and PA Tresco, (2005) Correlation of electrical impedance, cytokine expression, and histology at the biosensor-brain tissue interface, 30th Annual Meeting Transactions, Society for Biomaterials, 316.

Wolchok JC, Brokopp C, Underwood CJ, and PA Tresco, (2004) Design and validation of a novel bioreactor for investigating the response of vocal fold fibroblasts to vibrational stresses, Annual Fall Meeting Biomedical Engineering Society, 675.

Merrill DR and PA Tresco, (2004) Impedance characterization of microarray recording electrodes in vitro, 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 11.4.2.

Leung BK, Underwood CJ, and PA Tresco, (2004) Rat strain influences microglial cytokine release on materials of differing surface chemistry, 34th Annual Meeting Transactions Society of Neuroscience, 686.4.

Merrill DR, Winslow BD, Kim YT, Underwood CJ, and PA. Tresco, (2004) A novel tool for characterizing temporal changes at the biosensor-brain tissue interface. 34th Annual Meeting Transactions Society of Neuroscience, 793.15.

Biran R and PA Tresco, (2004) Microglial activation and neuronal loss surrounding chronically implanted intracortical microelectrode arrays, 34th Annual Meeting Transactions Society of Neuroscience, 685.5.

Leung BK, Underwood CJ, Biran R, and PA Tresco, (2003) Microglia adhere to a wide range of medically relevant materials and surface coatings, 33rd Annual Meeting Transactions, Society for Neuroscience, 743.12.

Bridge MJ and PA Tresco, (2003) A method of estimating diffusivity of brain tissue adjacent to implanted biomaterials, 33rd Annual Meeting Transactions, Society for Neuroscience, 11.10.

Walsh JF, Messina DJ, and PA Tresco, (2003) Human glial precursors are unaffected by nanometer scale surface topography, 33rd Annual Meeting Transactions, Society for Neuroscience, 674.14.

Roberts MC, Biran R, Webb K, and PA Tresco, (2003) A novel approach for engineering a bridge for nerve repair, 33rd Annual Meeting Transactions, Society for Neuroscience, 790.15.

Merrill DR, Biran R and PA Tresco, (2003) The effects of adsorbed proteins and cellular species on microelectrode array performance, 33rd Annual Meeting Transactions, Society for Neuroscience, 414.12.

Smeal RM, Rabbitt R, and PA Tresco, (2003) Guidance of neurites on curved substrates is enhanced by low dose taxol and cytochalasin, 33rd Annual Meeting Transactions, Society for Neuroscience, 35.2.

Kim Y-T, Underwood CJ, Bridge MJ, and PA Tresco, (2003) Brain reactivity to transplanted fibroblasts decreases bioavailability of small molecules in adjacent tissue, 33rd Annual Meeting Transactions, Society for Neuroscience, 150.6.

Biran R and PA Tresco, (2003) Quantitative characterization of brain tissue reaction to intracortical microelectrode arrays, 33rd Annual Meeting Transactions, Society for Neuroscience, 414.8.

Tresco, PA, (2003) Tissue engineering applications in spinal cord repair, NSW Premiers Forum on Spinal Cord Repair, Sydney, Australia.

Tresco, PA, (2003) Engineering vocal fold extracellular matrix, American Association for the Advancement of Science, Denver, CO.

Tresco, PA, (2003) Mining the borderland of biomaterials in the CNS, Engineering Tissue Growth International Conference & Exposition.

Kim Y-T, Underwood CJ, and PA Tresco, (2003) Encapsulated transplanted fibroblasts increase brain tissue reactivity in adjacent parenchyma, Transactions of 29th Annual Meeting Society for Biomaterials, 76.

Zhang N, Bridge MJ, and PA Tresco, (2003) Variations in surface architecture alter the brain tissue response to implanted hollow fiber membranes, Transactions of 29th Annual Meeting Society for Biomaterials, 445.

Walsh JF, Messina DJ, and PA Tresco, (2003) Unlike astrocytes, glial precursors are insensitive to parallel, sub-micron scale surface features, Transactions of 29th Annual Meeting Society for Biomaterials, 261.

Smeal RM and PA Tresco, (2003) Age dependent response of neurons to substrate curvature, Transactions of 29th Annual Meeting Society for Biomaterials, 450.

Wen X and PA Tresco, (2003) Brain tissue response to implanted poly(lactide-co-glycolide) hollow fiber membranes, Transactions of 29th Annual Meeting Society for Biomaterials, 442.

Roberts MC, Biran R, Webb K, Broadhead KW, and PA Tresco, (2003) Three-dimensional astrocyte cultures as bridging substrates for regenerating axons, Transactions of 29th Annual Meeting Society for Biomaterials, 449.

Bridge MJ, Broadhead KW, and PA Tresco, (2003) Modeling diffusive transport of solutes in brain tissue adjacent to implanted cell encapsulation membranes, Transactions of 29th Annual Meeting Society for Biomaterials, 525.

Biran R and PA Tresco, (2003) Brain tissue response to implanted micromachined microelectrode arrays, Transactions of 29th Annual Meeting Society for Biomaterials, 316.

Webb K and PA Tresco, (2003) Engineering the biomechanical properties of connective tissue in elastomeric porous substrates, Transactions of 29th Annual Meeting Society for Biomaterials, 725.

Messina DJ, Alder L, and PA Tresco, (2002) Stereological comparison of pure and mixed populations of human neural precursors transplanted into intact adult rat brain, 32nd Annual Meeting Transactions Society for Neuroscience, 726.10.

Kim YT, Broadhead KW, Messina DJ, and PA Tresco, (2002) Reversible delivery of cell derived soluble factors to brain tissue using a refillable cell encapsulation device, 32nd Annual Meeting Transactions Society for Neuroscience, 387.14.

Biran R, Manwaring ME, Walsh JF, and PA Tresco, (2002) Induced organization of reactive astrocytes and meningeal monolayers is sufficient to increase the directed outgrowth of regenerating axons, 32nd Annual Meeting Transactions Society for Neuroscience, 825.2.

Webb K, Smeal RM, Hitchcock RW, Gray SW, and PA Tresco, (2002) The development of soft and flexible substrates for tissue engineering, Transactions of 28th Annual Meeting Society for Biomaterials, 25:194.

Webb K, Li W, Hitchcock RW, Gray SD, and PA Tresco, (2002) Three-dimensional culture of human laryngeal fibroblasts changes the expression profile of ECM-related gene products, Transactions of 28th Annual Meeting Society for Biomaterials, 25:195.

Hitchcock RW, Thomas S, Webb K, Gray SD, Titze I, and PA Tresco, (2002) Applying controlled vibration and tension to tissue engineered constructs, Transactions of 28th Annual Meeting Society for Biomaterials, 25:215.

Manwaring ME, Walsh JF, and PA Tresco, (2002) Remodeling fibroblastic tissue at the neural biomaterial interface, Transactions of 28th Annual Meeting Society for Biomaterials, 25:46.

Walsh JF, Manwaring ME, and PA Tresco, (2002) Engineered adult fibroblast monolayers are capable of promoting directed outgrowth of axotomized adult neurons, Transactions of 28th Annual Meeting Society for Biomaterials, 25:49.

Smeal RM, Rabbitt R, and PA Tresco, (2002) Biomaterial surface curvature is sufficient to direct neurite outgrowth, Transactions of 28th Annual Meeting Society for Biomaterials, 25:355.

Kim Y-T, Broadhead KW, Messina DJ, and PA Tresco, (2002) Reversible delivery of cell-derived soluble factors to brain tissue using a refillable cell encapsulation device, Transactions of 28th Annual Meeting Society for Biomaterials, 25:115.

Leung BK, Zhang N, Messina DJ, Biran R, and PA Tresco, (2002) Changes in hollow fiber membrane surface morphology and chemistry alter adult brain tissue response, Transactions of 28th Annual Meeting Society for Biomaterials, 25:708.

Bridge MJ, Broadhead KW, Kim Y-T, Messina DJ, and PA Tresco, (2002) Estimating the diffusive properties of an implanted cell encapsulation membrane and the adjacent tissue within the adult brain tissue, Transactions of 28th Annual Meeting Society for Biomaterials, 25:283.

Broadhead KW, Kang E, and PA Tresco, (2002) The influence of spinneret size and flow rate on the structure and permeability of PAN-PVC hollow fiber membrane, Transactions of 28th Annual Meeting Society for Biomaterials, 25:692.

Wen X and PA Tresco, (2002) Biodegradable hollow fiber membrane for creating space within the CNS, Transactions of 28th Annual Meeting Society for Biomatearials, 25:50.

Dietrich J, Messina DJ, Tresco PA, Noble M, and M Mayer-Proschel, (2001) Characterization of human glia restricted precursor (HGRP) cells in vitro and after transplantation into the adult mammalian brain, 31st Annual Meeting Transactions Society for Neuroscience, 360.18.

Herrera JJ, Yang H, Zhang SC, Proschel C, Tresco PA, Duncan I, Luskin M, and M Mayer-Proschel, (2001) Embryonic-derived glial-restricted precursor cells can differentiate into astrocytes and oligodendrocytes in vivo, 31st Annual Meeting Transactions Society for Neuroscience, 370.3.

Messina DJ, Alder L, and PA Tresco, (2001) Characterization of eNCAM-positive subpopulation of human progenitor cells following transplantation into the adult rat brain, 31st Annual Meeting Transactions Society for Neuroscience, 371.12.

Smeal RM, Rabbitt R, Clark GA, and PA Tresco, (2001) Axonal stiffness may be an important guidance mechanism, 31st Annual Meeting Transactions Society for Neuroscience, 795.11.

Underwood CJ, Zhang N, Kim YT, Hitchcock R, Bridge M, Biran R, and PA Tresco, (2001) CNS reactivity to implanted biomaterials is suppressed by soluble factors derived from co-implanted young astrocytes, 31st Annual Meeting Transactions Society for Neuroscience, 213.12.

Tresco PA, Messina DJ, Jorgensen CM, and GG Greuger, (2001) Stability of transgene expression by genetically modified immortalized fibroblasts in an encapsulated device in the subcutaneous space of athymic mice, Annual Meeting Society of Investigative Dermatology.

Zhang N, Biran R, and PA Tresco, (2001) CNS reactivity to hollow fiber membranes is dramatically suppressed by soluble factors derived from co-transplanted young astrocytes, 27th Annual Meeting Transactions Society of Biomaterials, 24:183.

Kim Y-T, Zhang N, Manwaring M, Biran R, and PA Tresco, (2001) Adult rat brain tissue reactivity is enhanced by biomaterials that chronically traverse the leptomeninges, 27th Annual Meeting Transactions Society of Biomaterials, 24:552.

Hitchcock RW, Kim Y-T, and PA Tresco, (2001) A refillable cell encapsulation device for examining the influence of cell-derived soluble factors on biomaterial induced host reactivity, 27th Annual Meeting Transactions Society of Biomaterials, 24:74.

Kang E, Broadhead KW, and PA Tresco, (2001) Functional properties of PAN-PVC membranes used in various tissue engineering applications, 27th Annual Meeting Transactions Society of Biomaterials, 24:558.

Bridge M, Broadhead KW, Hitchcock RW, Webb K, and PA Tresco, (2001) A novel instrument for transport characterization of cell encapsulation membranes, 27th Annual Meeting Transactions Society of Biomaterials, 24:352.

Webb K, Biran R, Herrera JJ, Budko E, and PA Tresco, (2001) Comparison of neurite outgrowth on astrocyte monolayers cultures on materials of varying topography and adsorbed proteins, 27th Annual Meeting Transactions Society of Biomaterials, 24:12.

Broadhead KW and PA Tresco (2001) The effect of membrane transport on the release of dopamine from encapsulated PC12 cells, 27th Annual Meeting Transactions Society of Biomaterials, 24:181.

Manwaring M, Biran R, and PA Tresco, (2001) Convesion of inhibitory biohybrid constructs into permissive ones that direct neurite outgrowth by treatment with the cell adhesion molecule L1, 27th Annual Meeting Transactions Society of Biomaterials, 24:555.

Biran R, Webb K, Budko, and PA Tresco, (2001) PEO-immobilized fibronectin enhances motility and alters the morphology of sensory growth cones, 27th Annual Meeting Transactions Society of Biomaterials, 24:9.

Wen X, Webb K, and PA Tresco, (2001) Multifilament entubulation burdging device for axonal guidance and regeneration, 27th Annual Meeting Transactions Society of Biomaterials, 24:182.

Tresco PA, (2000) Biointeractive materials for engineering the neural interface, Annual Materials Research Society Meeting, #OO 1.1.

Messina DJ, Mayer-Proschel M, Rao M, and PA Tresco (2000) Migratory capacity and differentiation potential of human neuroepithelial precursor cells in adult rat brain, 30th Annual Meeting Transactions Society for Neuroscience, 415.9.

Smeal RM, Rabbit RD, and PA Tresco, (2000) Substrate curvature restricts the directional outgrowth of dorsal root ganglion cell: implications for development, 30th Annual Meeting Transactions Society for Neuroscience, 508.14.

Biran R, Noble MD, and PA Tresco, (2000) Astrocyte cytoskeletal alignment is required for directional growth of adherent neurons, 30th Annual Meeting Transactions Society for Neuroscience, 508.15.

Biran R, Noble MD, and PA Tresco, (2000) Directionally organized primary nervous tissue by biomaterials templating, 6th World Biomaterials Congress Transactions, #7.

Smeal RM, Biran R, Budko E, Noble MD and PA Tresco, (2000) The development of a biosynthetic analogue to a pioneering axon, 6th World Biomaterials Congress Transactions, #161.

Webb K, Budko E, and PA Tresco, (2000) Neuron selective substrate by immobilization of cell adhesion molecules, 6th World Biomaterials Congress Transactions, #394.

Manwaring M, Noble MD, and PA Tresco, (2000) Surface microarchectiture induced matrix organization promotes alignment in multiple cell layers, 6th World Biomaterials Congress Transactions, #451.

Budko E, Biran R, Noble MD, and PA Tresco (2000) Biomaterial surface physicochemical properties influence neurite outgrowth and directionality, 6th World Biomaterials Congress Transactions, #1003.

Robins M, Broadhead KW, and PA Tresco (2000) Evaluation of polysulfone phase inversion membrane for cell encapsulation, 6th World Biomaterials Congress Transactions, #1498.

Patrick A. Tresco, PhD
Professor, Department of Bioengineering
Associate Dean, College of Engineering

B.A.  Biology (1979) Susquehanna University
M.S.  Pharmacology and Toxicology (1983) University of Rhode Island
Ph.D.  Medical Sciences (1991) Brown University