RECENT PUBLICATIONS

Z. Gao, H.D. Fain, N. Rapoport (2005) Controlled and Targeted Tumor Chemotherapy by Micellar-Encapsulated Drug and Ultrasound. J. Control. Release, 102, 201-223.

N. Rapoport (2005) Ultrasound Activated Micellar Drug Delivery and Tumor Targeting. In: Stimuli Sensitive Particulates and Assemblies, MML Series, Citus Books, ed. R. Arshadi, ch. 7, in press.

Z. Gao, H.D. Fain, N. Rapoport (2004) Ultrasound-Enhanced Tumor Targeting of Polymeric Micellar Drug Carriers. Molecular Pharmaceutics, 1: 317-330

N.Y. Rapoport, D.A. Christensen, H. D. Fein, L. Barrows, Z. Gao  (2004) Ultrasound-triggered drug targeting to tumors in vitro and in vivo. Ultrasonics 42: 943-950.

N. Rapoport (2004) Combined Cancer Therapy by Micellar-Encapsulated Drug and Ultrasound. International Journal of Pharmaceutics 277: 155-162.

Rapoport, N. (2004) Factors Affecting Ultrasound Interactions with Polymeric Micelles and Viable Cells. in: Carrier-Based Drug Delivery. ACS Symposium Series 879, S. Swenson, Ed., Washington , DC , pp. 161-173.

Rapoport, N., Pitt, W.G., Sun Hao, Nelson, J.L. (2003) Drug Delivery in Polymeric Micelles: from in vitro to in vivo. J. Control Rel., 91: 85-95.

Rapoport, N. (2003) Controlled Drug Delivery to Drug-Sensitive and Multidrug Resistant cells: Effects of Pluronic Micelles and Ultrasound. in: Advances in Controlled  Drug Delivery. ACS Symposium Book Series, ed. S. Dinh and P. Liu , Washington DC, 2003, pp. 85-101.

RELEVANT PUBLICATIONS (last three years).

      Z. Gao, H.D. Fain, N. Rapoport (2004) Controlled and Targeted Tumor Chemotherapy by

Micellar-Encapsulated Drug and Ultrasound. Journal of Controlled Release 102 (1) 203-222.

Z. Gao, H.D. Fain, N. Rapoport (2004) Ultrasound-Enhanced Tumor Targeting of Polymeric Micellar Drug Carriers. Molecular Pharmaceutics, 1: 317-330.

N.Y. Rapoport, D.A. Christensen, H. D. Fein, L. Barrows, Z. Gao  (2004) Ultrasound-triggered drug targeting to tumors in vitro and in vivo. Ultrasonics, 42: 943-950.

N. Rapoport (2004) Combined Cancer Therapy by Micellar-Encapsulated Drug and Ultrasound. International Journal of Pharmaceutics 277: 155-162.

Patent US 6,649,702 Stabilization and Acoustic Activation of Polymeric Micelles for Drug Delivery. Issued November 18, 2003 to Natalya Rapoport and William G. Pitt.

Rapoport, N. (2003) Controlled Drug Delivery to Drug-Sensitive and Multidrug Resistant cells: Effects of Pluronic Micelles and Ultrasound. in: Advances in Controlled  Drug Delivery. ACS Symposium Series 846, S. Dinh and P. Liu, Eds., Washington, DC, 2003, pp. 85-101.

Rapoport, N. (2004) Factors Affecting Ultrasound Interactions with Polymeric Micelles and Viable Cells. in: Carrier-Based Drug Delivery. ACS Symposium Series 879, S. Swenson, Ed., Washington , DC , pp. 161-173.

Rapoport, N., Pitt, W.G., Sun Hao, Nelson, J.L. (2003) Drug Delivery in Polymeric Micelles: from in vitro to in vivo. J. Control Rel., 91: 85-95.

Marin A, Sun Hao, Husseini GA, Pitt WG, Christensen DA, Rapoport NY (2002) Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake. J Control Rel. 84: 39-47

      Rapoport, N, Marin, A, Christensen, D.A. (2002) Ultrasound-Activated Drug Delivery. Drug Delivery Systems and Sciences, 2: 37-46.

Rapoport, N., Marin, A. Luo, Yi, Prestwich, G, Muniruzzaman, Md. (2002) Intracellular Uptake and Trafficking of Pluronic Micelles in Drug-Sensitive and MDR Cells: Effect on the Intracellular Drug Localization. J. Pharm. Sci. 91: 157-170.

Husseini, G.A., Rapoport, N.Y., Christensen, D.A., Pruitt, J.D., Pitt, W.G. (2002) Kinetics of ultrasonic release of Doxorubicin from Pluronic P-105 micelles. Colloids and Surfaces B: Biointerfaces 24, 253-264.

Muniruzzaman , MD , Marin, A., Yi Luo, Prestwich, G., Pitt, W.G., Husseini, G., Rapoport (2002) N. Intracellular Uptake of Pluronic Copolymer: Effect of the Aggregation State . Colloids and Surfaces B: Biointerfaces  25: 233-241.

Marin, A., Muniruzzaman, M., Rapoport, N. (2001) Mechanism of the ultrasound activation of micellar drug delivery. J. Control. Rel. 75: 69-81

Marin, A., Muniruzzaman, M., Rapoport, N. (2001) Acoustic activation of drug delivery from polymeric micelles: effect of pulsed ultrasound. J. Control. Rel. 71: 239-249.

Husseni, G.A., Myrup, G.D., Pitt, W.G., Christensen, D.A., Rapoport , N.Y. (2000) Factors affecting acoustically triggered release of drugs from polymeric micelles. J. Control. Rel. 69:  43-52.

Rapoport, N., Marin, A.P., Timoshin, A.A. (2000) Effect of a polymeric surfactant on electron transport in HL-60 cells. Arch. Biochem. Biophys. 384: 100-108.

Pruitt, J.D., Husseini, G., Rapoport, N., Pitt, W.G. (2000) Stabilization of Pluronic P-105 micelles with an interpenetrating network of N,N-diethylacrylamide. Macromolecules 33: 9306-9309.

Rapoport, N. Stabilization and acoustic activation of Pluronic micelles for tumor-targeted drug delivery (1999) Colloids and Surface B: Biointerfaces, 3: 93-111.

Rapoport , N.Y. , Herron, J.N., Pitt, W.G., Pitina, L.  Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60: effect of micelle structure and ultrasound on the intracellular drug uptake. J. Control. Rel., 1999, 58: 153-162.

Husseini, G., El-Fayoumi, R., O’Neil, K., Rapoport, N, Pitt, W. (1999) DNA damage induced by micellar-delivered Doxorubicin and ultrasound: comet assay study. Cancer Letters 154: 211-216

Rapoport, N., Pitt, W.G., Smirnov, A.I., and Timoshin, A.I.(1999)  Bioreduction of Tempone and Spin-labeled Gentamicin by P. aeruginosa cells: Kinetics and Effect of Ultrasound. Archives Biochem. Biophys., 362: 233-241

Selected project-related publications (earlier years)

Rapoport, N., Munshi N.,  Pitina, L, Pitt W.G. (1997) Pluronic micelles as vehicles for tumor-specific delivery of two anticancer drugs to HL-60 cells using acoustic activation. Polymer Preprints 38: 620-621

Rapoport, N. and Pitina, L (1998) Intracellular distribution and intracellular dynamics of a spin-labeled analog of Doxorubicin by fluorescence and EPR spectroscopy. J. Pharm. Sci. 87: 321-325.

Munshi, N., Rapoport, N., Pitt, W.G. (1997) Ultrasonic activated drug delivery from Pluronic P-105 micelles. Cancer Letters 117: 1-7 .

 Rapoport, N., Smirnov, A., Timoshin, A., Pitt, W.G., Pratt, A.M. (1997) The effect of ultrasound on the permeability of P. aeruginosa cell membranes as probed by the uptake of lipophilic spin probe. Archives of Biochemistry and Biophysics  344:114-124.

Rapoport, N., Caldwell, K. (1994) Structural transitions in micellar solutions of Pluronic P-105: an electron paramagnetic resonance investigation. Colloids and Surfaces B: Biointerfaces, 3: 217-228

Li, J.-T., Caldwell , K.D., Rapoport, N. (1994) Surface Properties of Pluronic-Coated Polymeric Colloids. Langmuir, 10:4475-4482.

Rapoport, N. and Tresco, P. A. (1994) Developing Paramagnetic Polymeric Membranes for Tracking Transplanted Cells. in: Biomedical Engineering Recent Developments. Ed.J. Vossoughi, University of District of Columbia , Washington DC , pp. 752-755.

Books, book chapters, and reviews:

Rapoport, N. Controlled Drug Delivery to Drug-Sensitive and Multidrug Resistant cells: Effects of Pluronic Micelles and Ultrasound. ACS Book Series, 2002, in print.

N. Rapoport and A.A. Efros (1995). Monte Carlo Simulation of Polymer High Temperature Degradation and Fracture. in: High-Temperature Properties and Applications of Polymeric Materials, ACS Symposium Book Series 603, Ed. M.R. Tant, J.W. Connell, H.L.N. McManus, American Chemical Society, Washington, DC. Ch. 10, pp. 155-168.

Popov, A.A., Rapoport, N. Ya and Zaikov, G.E., Oxidation of Stressed Polymers, Gordon and Breach Science Publishers, 1991, 333 pp.

White, J.A. and Rapoport, N., Stress Effects on Polymer Durability in the Oxidative Environment. A review. Trends in Polymer Science 1994, 2: 197-202

BOOKS AND BOOK CHAPTERS:

Rapoport, N. (2004) Factors Affecting Ultrasound Interactions with Polymeric Micelles and Viable Cells. in: Carrier-Based Drug Delivery. ACS Symposium Series 879, S. Swenson, Ed., Washington , DC , pp. 161-173.

Rapoport, N., Marin, SA., Muniruzzaman , Md. , Christensen, D.A. (2003) Controlled Drug Delivery to Drug-Sensitive and Multidrug Resistant Cells: Effect of Pluronic Micelles and Ultrasound. In: Advances in Controlled Drug delivery, ACS Book Series, Drug Delivery of Macromolecules, ed. S. Dinh and P. Liu, Washington DC , pp. 85-101.

Popov, A.A., Rapoport, N. Ya and Zaikov, G.E., Oxidation of Stressed Polymers, Gordon and Breach Science Publishers, 1991, 333 pp.

N. Rapoport and A.A. Efros (1995). Monte Carlo Simulation of Polymer High Temperature Degradation and Fracture. in: High-Temperature Properties and Applications of Polymeric Materials, ACS Symposium Book Series 603, Ed. M.R. Tant, J.W. Connell, H.L.N. McManus, American Chemical Society, Washington, DC. Ch. 10, pp. 155-168.

White, J.A. and Rapoport, N., Stress Effects on Polymer Durability in the Oxidative Environment. A review. Trends in Polymer Science 1994, 2: 197-202

PATENTS

Rapoport, N. Synergistic compositions for the prevention of polymer degradation. U.S. 07/982,490 (1993).

Rapoport, N, Pitt, W.G. Acoustically Activated Localized Drug Delivery. 

 PROFESSIONAL SOCIETIES

                                 Member of the American Chemical Society

                                 Member of the Controlled Release Society

                                 Member of the International EPR Society