Congratulations to
Jonathan Hartley
, PhD Biomedical Engineering student, recipient of the
National Research Service Award (F31)
. Jonathan proposed to develop a coiled-coil therapeutic for the treatment of non-Hodgkin’s lymphoma. The therapeutic comprises a pair of coiled-coil forming peptides with one peptide conjugated to an antibody fragment and multiple copies of the other peptide attached to a N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer. The conjugates self-assemble at the surface of cancerous B cells and crosslink surface proteins to induce programmed cell death. The goal of the study is to use super-resolution imaging to study the interactions between the conjugates and the cell to optimize the therapeutic design. Jonathan’s F31 award will support his research for the next two years. Jonathan is advised by Professor
Jindrich Kopecek.