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Friday January 12, 2018 -- Systems Analysis of Cancer Therapeutics Resistance: Adaptation, Heterogeneity, and Microenvironment

SMBB 2650, 11:45 am

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Speaker: Doug Lauffenburger, MIT

Douglas A. Lauffenburger is Ford Professor of Bioengineering and (founding) Head of the Department of Biological Engineering at MIT. His major research interests are in cell engineering: the fusion of engineering with molecular cell biology, with central focus on systems biology approaches to complex pathophysiology in application to drug discovery and development. Lauffenburger has co-authored a monograph entitled Receptors: Models for Binding, Trafficking & Signaling, published by Oxford University Press in 1993; he also co-edited the book entitled Systems Biomedicine: Concepts and Perspectives, published by Elsevier in 2010. More than 100 doctoral students and postdoctoral associates have undertaken research education under his supervision.

Prof. Lauffenburger has served as a consultant or scientific advisory board member for numerous biotechnology and pharmaceutical companies, and his awards include the Galletti Award from AIMBE, the Coburn Award and Walker Award from AIChE, and the Distinguished Lecture Award and the Shu Chien Lifetime Achievement Award from BMES. He is a member of the National Academy of Engineering and the American Academy of Arts & Sciences, and has served as President of the Biomedical Engineering Society, Chair of the College of Fellows of American Institute for Medical & Biological Engineering, on the Advisory Council for NIGMS, and as a co-author of the 2009 NRC report on A New Biology for the 21st Century.

Presentation Abstract:

A central challenge in cancer therapeutics is resistance -- ‘primary / innate’ as well as ‘secondary / acquired’ -- manifested in any of a variety of forms to almost every mode of treatment. Understanding underlying causes of resistance and developing capabilities for addressing them more effectively requires comprehension from multi-variate systems perspective. In this seminar, I will present a set of examples of recent work from our laboratory (in close collaboration with a number of others), which offer new insights being gained from application of integrated experimental/computational approaches to clinically-relevant challenges including tumor adaptation, tumor heterogeneity, and tumor microenvironment influence.

Faculty Host: Tara Deans Contact: