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Jeffrey A. Weiss

Phone: 801-634-5442
Office: 2458 MEB

Jeffrey A. Weiss

Professor, Department of Biomedical Engineering;
Adjunct Professor, Department of Orthopedics and School of Computing
ASME Van C. Mow Medal, 2013
Fellow, AIMBE, 2006-
Fellow, ASME, 2018-
ASME Y-C. Fung Award, 2002
NSF CAREER Award, 2002
PhD, Bioengineering, University of Utah, 1994
MS, Bioengineering, UC San Diego, 1990
BS, Bioengineering, UC San Diego, 1989


Experimental and Computational Biomechanics; Orthopedic Biomechanics; Mechanics of Angiogenesis; FEBio software project

Current Research

Research in the Musculoskeletal Research Laboratories focuses on the development and application of experimental and computational techniques to the study of musculoskeletal and cardiovascular cells, tissues and organs. A central theme of our approach to research is the use of multidisciplinary techniques to address research questions that would be impossible to investigate using approaches in a single technical discipline. Our laboratory also leads the development and support of the FEBio software suite (Finite Elements for Biomechanics,

Active Grants:
Targeting Collagen Mechanical Damage using Collagen Hybridizing Peptides (1R01AR071358)
FEBio: Finite Elements for Biomechanics (PI; NIH/NIGMS #R01 GM083925)
Neovessel Guidance in Angiogenesis (R01HL131856)
Mechanical Regulation of Vascular Growth and Remodeling (R01AR069297)
Population-Based Shape and Biomechanical Analysis of Hip Pathoanatomy (Co-i: NIH/NIBIB R01EB016701)

Selected Publications

Maas SA, Ateshian GA, Weiss JA, FEBio: History and Advances. Annu Rev Biomed Eng 2017 Jun 21;19:279-299

Zitnay JL, Li Y, Qin Z, San BH, Depalle B, Reese SP, Buehler MJ, Yu SM, Weiss JA, Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides. Nat Commun 2017 Mar 22;8:14913

Klennert BJ, Ellis BJ, Maak TG, Kapron AL, Weiss JA, The mechanics of focal chondral defects in the hip. J Biomech 2017 Feb 8;52:31-37

Reese SP, Farhang N, Poulson R, Parkman G, Weiss JA, Nanoscale Imaging of Collagen Gels with Focused Ion Beam Milling and Scanning Electron Microscopy. Biophys J 2016 Oct 18;111(8):1797-1804

Maas SA, Erdemir A, Halloran JP, Weiss JA, A general framework for application of prestrain to computational models of biological materials. J Mech Behav Biomed Mater 2016 Aug;61:499-510

Maas SA, Ellis BJ, Rawlins DS, Weiss JA, Finite element simulation of articular contact mechanics with quadratic tetrahedral elements. J Biomech 2016 Mar 21;49(5):659-67

Sibole SC, Maas S, Halloran JP, Weiss JA, Erdemir A, Evaluation of a post-processing approach for multiscale analysis of biphasic mechanics of chondrocytes, DOI: 10.1080/10255842.2013.809711. Comput Methods Biomech Biomed Engin 2016;19(1):ii

Henninger HB, Valdez WR, Scott SA, Weiss JA, Elastin governs the mechanical response of medial collateral ligament under shear and transverse tensile loading. Acta Biomater 2015 Oct;25:304-12

Edgar LT, Maas SA, Guilkey JE, Weiss JA, A coupled model of neovessel growth and matrix mechanics describes and predicts angiogenesis in vitro. Biomech Model Mechanobiol 2015 Aug;14(4):767-82

Edgar LT, Hoying JB, Weiss JA, In Silico Investigation of Angiogenesis with Growth and Stress Generation Coupled to Local Extracellular Matrix Density. Ann Biomed Eng 2015 Jul;43(7):1531-42

Merrell AJ, Ellis BJ, Fox ZD, Lawson JA, Weiss JA, Kardon G, Muscle connective tissue controls development of the diaphragm and is a source of congenital diaphragmatic hernias. Nat Genet 2015 May;47(5):496-504

Ateshian GA, Henak CR, Weiss JA, Toward patient-specific articular contact mechanics. J Biomech 2015 Mar 18;48(5):779-86

Henak CR, Abraham CL, Peters CL, Sanders RK, Weiss JA, Anderson AE, Computed tomography arthrography with traction in the human hip for three-dimensional reconstruction of cartilage and the acetabular labrum. Clin Radiol 2014 Oct;69(10):e381-91

Swedberg AM, Reese SP, Maas SA, Ellis BJ, Weiss JA, Continuum description of the Poisson's ratio of ligament and tendon under finite deformation. J Biomech 2014 Sep 22;47(12):3201-9

Underwood CJ, Edgar LT, Hoying JB, Weiss JA, Cell-generated traction forces and the resulting matrix deformation modulate microvascular alignment and growth during angiogenesis. Am J Physiol Heart Circ Physiol 2014 Jul 15;307(2):H152-64

Henak CR, Kapron AL, Anderson AE, Ellis BJ, Maas SA, Weiss JA, Specimen-specific predictions of contact stress under physiological loading in the human hip: validation and sensitivity studies. Biomech Model Mechanobiol 2014 Apr;13(2):387-400

Henak CR, Abraham CL, Anderson AE, Maas SA, Ellis BJ, Peters CL, Weiss JA, Patient-specific analysis of cartilage and labrum mechanics in human hips with acetabular dysplasia. Osteoarthritis Cartilage 2014 Feb;22(2):210-7

Edgar LT, Underwood CJ, Guilkey JE, Hoying JB, Weiss JA, Extracellular matrix density regulates the rate of neovessel growth and branching in sprouting angiogenesis. PLoS One 2014;9(1):e85178

Reese SP, Underwood CJ, Weiss JA, Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels. Matrix Biol 2013 Oct-Nov;32(7-8):414-23

Reese SP, Ellis BJ, Weiss JA, Micromechanical model of a surrogate for collagenous soft tissues: development, validation and analysis of mesoscale size effects. Biomech Model Mechanobiol 2013 Nov;12(6):1195-204

Henak CR, Carruth ED, Anderson AE, Harris MD, Ellis BJ, Peters CL, Weiss JA, Finite element predictions of cartilage contact mechanics in hips with retroverted acetabula. Osteoarthritis Cartilage 2013 Oct;21(10):1522-9

Henninger HB, Underwood CJ, Romney SJ, Davis GL, Weiss JA, Effect of elastin digestion on the quasi-static tensile response of medial collateral ligament. J Orthop Res 2013 Aug;31(8):1226-33

Henak CR, Anderson AE, Weiss JA, Subject-specific analysis of joint contact mechanics: application to the study of osteoarthritis and surgical planning. J Biomech Eng 2013 Feb;135(2):021003

Edgar LT, Sibole SC, Underwood CJ, Guilkey JE, Weiss JA, A computational model of in vitro angiogenesis based on extracellular matrix fibre orientation. Comput Methods Biomech Biomed Engin 2013;16(7):790-801

Krishnan L, Chang CC, Nunes SS, Williams SK, Weiss JA, Hoying JB, Manipulating the microvasculature and its microenvironment. Crit Rev Biomed Eng 2013;41(2):91-123

Harris MD, Anderson AE, Henak CR, Ellis BJ, Peters CL, Weiss JA, Finite element prediction of cartilage contact stresses in normal human hips. J Orthop Res 2012 Jul;30(7):1133-9

Maas SA, Ellis BJ, Ateshian GA, Weiss JA, FEBio: finite elements for biomechanics. J Biomech Eng 2012 Jan;134(1):011005

Henak CR, Ellis BJ, Harris MD, Anderson AE, Peters CL, Weiss JA, Role of the acetabular labrum in load support across the hip joint. J Biomech 2011 Aug 11;44(12):2201-6

Reese SP, Maas SA, Weiss JA, Micromechanical models of helical superstructures in ligament and tendon fibers predict large Poisson's ratios. J Biomech 2010 May 7;43(7):1394-400

Henninger HB, Reese SP, Anderson AE, Weiss JA, Validation of computational models in biomechanics. Proc Inst Mech Eng H 2010;224(7):801-12

Phatak NS, Maas SA, Veress AI, Pack NA, Di Bella EV, Weiss JA, Strain measurement in the left ventricle during systole with deformable image registration. Med Image Anal 2009 Apr;13(2):354-61

Henninger HB, Maas SA, Shepherd JH, Joshi S, Weiss JA, Transversely isotropic distribution of sulfated glycosaminoglycans in human medial collateral ligament: a quantitative analysis. J Struct Biol 2009 Mar;165(3):176-83

Lujan TJ, Underwood CJ, Jacobs NT, Weiss JA, Contribution of glycosaminoglycans to viscoelastic tensile behavior of human ligament. J Appl Physiol (1985) 2009 Feb;106(2):423-31

Anderson AE, Ellis BJ, Maas SA, Peters CL, Weiss JA, Validation of finite element predictions of cartilage contact pressure in the human hip joint. J Biomech Eng 2008 Oct;130(5):051008

Krishnan L, Underwood CJ, Maas S, Ellis BJ, Kode TC, Hoying JB, Weiss JA, Effect of mechanical boundary conditions on orientation of angiogenic microvessels. Cardiovasc Res 2008 May 1;78(2):324-32

Krishnan L, Hoying JB, Nguyen H, Song H, Weiss JA, Interaction of angiogenic microvessels with the extracellular matrix. Am J Physiol Heart Circ Physiol 2007 Dec;293(6):H3650-8

Phatak NS, Sun Q, Kim SE, Parker DL, Sanders RK, Veress AI, Ellis BJ, Weiss JA, Noninvasive determination of ligament strain with deformable image registration. Ann Biomed Eng 2007 Jul;35(7):1175-87

Lujan TJ, Underwood CJ, Henninger HB, Thompson BM, Weiss JA, Effect of dermatan sulfate glycosaminoglycans on the quasi-static material properties of the human medial collateral ligament. J Orthop Res 2007 Jul;25(7):894-903

Anderson AE, Ellis BJ, Weiss JA, Verification, validation and sensitivity studies in computational biomechanics. Comput Methods Biomech Biomed Engin 2007 Jun;10(3):171-84

Ellis BJ, Debski RE, Moore SM, McMahon PJ, Weiss JA, Methodology and sensitivity studies for finite element modeling of the inferior glenohumeral ligament complex. J Biomech 2007;40(3):603-12

Ellis BJ, Lujan TJ, Dalton MS, Weiss JA, Medial collateral ligament insertion site and contact forces in the ACL-deficient knee. J Orthop Res 2006 Apr;24(4):800-10

Guilkey JE, Hoying JB, Weiss JA, Computational modeling of multicellular constructs with the material point method. J Biomech 2006;39(11):2074-86

Weiss JA, Gardiner JC, Ellis BJ, Lujan TJ, Phatak NS, Three-dimensional finite element modeling of ligaments: technical aspects. Med Eng Phys 2005 Dec;27(10):845-61

Veress AI, Gullberg GT, Weiss JA, Measurement of strain in the left ventricle during diastole with cine-MRI and deformable image registration. J Biomech Eng 2005 Dec;127(7):1195-207

Anderson AE, Peters CL, Tuttle BD, Weiss JA, Subject-specific finite element model of the pelvis: development, validation and sensitivity studies. J Biomech Eng 2005 Jun;127(3):364-73

Lujan TJ, Lake SP, Plaizier TA, Ellis BJ, Weiss JA, Simultaneous measurement of three-dimensional joint kinematics and ligament strains with optical methods. J Biomech Eng 2005 Feb;127(1):193-7

Shiu YT, Weiss JA, Hoying JB, Iwamoto MN, Joung IS, Quam CT, The role of mechanical stresses in angiogenesis. Crit Rev Biomed Eng 2005;33(5):431-510

Bonifasi-Lista C, Lake SP, Small MS, Weiss JA, Viscoelastic properties of the human medial collateral ligament under longitudinal, transverse and shear loading. J Orthop Res 2005 Jan;23(1):67-76

Krishnan L, Weiss JA, Wessman MD, Hoying JB, Design and application of a test system for viscoelastic characterization of collagen gels. Tissue Eng 2004 Jan-Feb;10(1-2):241-52

Gardiner JC, Weiss JA, Subject-specific finite element analysis of the human medial collateral ligament during valgus knee loading. J Orthop Res 2003 Nov;21(6):1098-106

Weiss JA, Gardiner JC, Bonifasi-Lista C, Ligament material behavior is nonlinear, viscoelastic and rate-independent under shear loading. J Biomech 2002 Jul;35(7):943-50

Hansen KA, Weiss JA, Barton J , Recruitment of tendon crimp with applied tensile strain. J Biomech Eng 2002 Feb;124(1):72-7

Weiss JA, Gardiner JC, Computational modeling of ligament mechanics. Crit Rev Biomed Eng 2001;29(3):303-71

Quapp KM, Weiss JA, Material characterization of human medial collateral ligament. J Biomech Eng 1998 Dec;120(6):757-63

Puso MA, Weiss J , Finite element implementation of anisotropic quasi-linear viscoelasticity using a discrete spectrum approximation. J Biomech Eng 1998 Feb;120(1):62-70

Weiss JA, Woo SL, Ohland KJ, Horibe S, Newton P , Evaluation of a new injury model to study medial collateral ligament healing: primary repair versus nonoperative treatment. J Orthop Res 1991 Jul;9(4):516-28